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The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and protein kinase superfamily involved in signal transduction pathways. This gene is closely linked to DRD2 gene (GeneID:1813) on chr 11, and a well studied restriction fragment length polymorphism (RFLP) designated TaqIA, was originally associated with the DRD2 gene, however, later was determined to be located in exon 8 of ANKK1 gene (PMIDs: 18621654, 15146457), where it causes a nonconservative amino acid substitution. It is not clear if this gene plays any role in neuropsychiatric disorders previously associated with Taq1A RFLP. [provided by RefSeq, Sep 2009]
[中文简述(自动翻译):]  由该基因编码的蛋白质属于丝氨酸/苏氨酸蛋白激酶家族,和蛋白激酶超家族参与信号转导通路。该基因是紧密相连的DRD2基因(GeneID:1813)于CHR 11,并指定TaqIA一个很好的研究限制性片段长度多态性(RFLP),最初是与DRD2基因有关,但后来被确定为位于外显子8的ANKK1基因(PMIDs:18621654,15146457),在那里它会导致非保守氨基酸取代。如果这个基因在神经精神障碍预先用Taq1A RFLP相关的任何作用目前尚不清楚。 [由RefSeq的,2009年09月提供]
ANKK1基因(以及对应的蛋白质)的细胞分布位置:
ANKK1基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Language Disorders | 0.120271442 | 1 | 0 | BeFree_CTD_human |
DOPAMINE RECEPTOR D2, REDUCED BRAIN DENSITY OF | 0.12 | 0 | 1 | CLINVAR |
Alcoholic Intoxication, Chronic | 0.017078432 | 19 | 0 | BeFree_GAD_LHGDN |
Schizophrenia | 0.009087065 | 7 | 3 | BeFree_GAD_LHGDN |
Dyskinetic syndrome | 0.005720142 | 3 | 0 | BeFree_LHGDN |
Obesity | 0.005276948 | 4 | 1 | BeFree_GAD |
Tobacco Use Disorder | 0.004734064 | 2 | 1 | GAD |
Nicotine Dependence | 0.004267125 | 7 | 2 | BeFree_GAD |
Marijuana Abuse | 0.002909916 | 3 | 10 | BeFree_GAD |
Neuroleptic Malignant Syndrome | 0.00272435 | 1 | 0 | LHGDN |
nervous system disorder | 0.002638474 | 2 | 0 | BeFree_GAD |
As If Personality | 0.002367032 | 1 | 0 | GAD |
Malignant neoplasm of urinary bladder | 0.002367032 | 1 | 0 | GAD |
Esophageal Neoplasms | 0.002367032 | 1 | 0 | GAD |
Fatigue | 0.002367032 | 1 | 0 | GAD |
Head and Neck Neoplasms | 0.002367032 | 1 | 0 | GAD |
Hyperphagia | 0.002367032 | 1 | 0 | GAD |
Laryngeal neoplasm | 0.002367032 | 1 | 0 | GAD |
Mouth Neoplasms | 0.002367032 | 1 | 0 | GAD |
Opioid-Related Disorders | 0.002367032 | 1 | 0 | GAD |
Pharyngeal Neoplasms | 0.002367032 | 1 | 0 | GAD |
Polycystic Ovary Syndrome | 0.002367032 | 1 | 1 | GAD |
Psychoses, Substance-Induced | 0.002367032 | 1 | 0 | GAD |
Delayed Puberty | 0.002367032 | 1 | 1 | GAD |
Precocious Puberty | 0.002367032 | 1 | 1 | GAD |
Weight Gain | 0.002367032 | 1 | 0 | GAD |
Ovarian Failure, Premature | 0.002367032 | 1 | 1 | GAD |
Substance-Related Disorders | 0.002367032 | 1 | 0 | GAD |
Thrombophilia | 0.002367032 | 1 | 1 | GAD |
Weight Gain Adverse Event | 0.002367032 | 1 | 0 | GAD |
Substance Dependence | 0.001085767 | 4 | 0 | BeFree |
Antisocial Personality Disorder | 0.000814326 | 3 | 0 | BeFree |
Bipolar Disorder | 0.000814326 | 3 | 0 | BeFree |
Alexithymia | 0.000542884 | 2 | 0 | BeFree |
Mental disorders | 0.000542884 | 2 | 0 | BeFree |
Heroin Dependence | 0.000542884 | 2 | 0 | BeFree |
Attention deficit hyperactivity disorder | 0.000542884 | 2 | 1 | BeFree |
Drug Dependence | 0.000542884 | 2 | 0 | BeFree |
alcohol use disorder | 0.000271442 | 1 | 0 | BeFree |
Anxiety Disorders | 0.000271442 | 1 | 1 | BeFree |
Cocaine Abuse | 0.000271442 | 1 | 0 | BeFree |
Mental Depression | 0.000271442 | 1 | 1 | BeFree |
Depressive disorder | 0.000271442 | 1 | 1 | BeFree |
Diabetes Mellitus, Non-Insulin-Dependent | 0.000271442 | 1 | 0 | BeFree |
Epilepsy | 0.000271442 | 1 | 0 | BeFree |
Disruptive, Impulse Control, and Conduct Disorders | 0.000271442 | 1 | 0 | BeFree |
melanoma | 0.000271442 | 1 | 0 | BeFree |
Parkinson Disease | 0.000271442 | 1 | 0 | BeFree |
Unipolar Depression | 0.000271442 | 1 | 1 | BeFree |
Alcohol abuse | 0.000271442 | 1 | 0 | BeFree |
Migraine Disorders | 0.000271442 | 1 | 0 | BeFree |
Antisocial behavior | 0.000271442 | 1 | 0 | BeFree |
Overweight | 0.000271442 | 1 | 0 | BeFree |
Opiate Addiction | 0.000271442 | 1 | 1 | BeFree |
Cocaine Dependence | 0.000271442 | 1 | 0 | BeFree |
Bipolar I disorder | 0.000271442 | 1 | 0 | BeFree |
Major Depressive Disorder | 0.000271442 | 1 | 1 | BeFree |
NEUROTICISM | 0.000271442 | 1 | 1 | BeFree |
Executive dysfunction | 0.000271442 | 1 | 0 | BeFree |
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