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This gene encodes a member of a family of secreted proteins that function in angiogenesis. The encoded protein, which is expressed predominantly in the liver, is further processed into an N-terminal coiled-coil domain-containing chain and a C-terminal fibrinogen chain. The N-terminal chain is important for lipid metablism, while the C-terminal chain may be involved in angiogenesis. Mutations in this gene cause familial hypobetalipoproteinemia type 2. [provided by RefSeq, Feb 2013]
[中文简述(自动翻译):]  这个基因编码一个家庭中的血管生成的作用分泌蛋白的一个成员。编码的蛋白质,它是在肝脏中表达,被进一步加工成N-末端卷曲螺旋结构域的链和C-末端的纤维蛋白原链。 N-末端链为脂质代谢重要,而C末端链可在血管生成有关。该基因家族事业型hypobetalipoproteine??mia突变2. [由RefSeq的,2013年2月提供]
ANGPTL3基因(以及对应的蛋白质)的细胞分布位置:
ANGPTL3基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Hypobetalipoproteinemia, Familial, 2 | 0.12 | 0 | 0 | CTD_human |
Diabetes Mellitus, Non-Insulin-Dependent | 0.004734064 | 2 | 0 | GAD |
Hypertriglyceridemia | 0.004734064 | 2 | 0 | GAD |
Hypertriglyceridemia result | 0.004734064 | 2 | 0 | GAD |
Coronary heart disease | 0.002638474 | 2 | 2 | BeFree_GAD |
Dyslipidemias | 0.002638474 | 2 | 0 | BeFree_GAD |
Inflammation | 0.002367032 | 1 | 0 | GAD |
Insulin Resistance | 0.002367032 | 1 | 0 | GAD |
Lipid Metabolism Disorders | 0.002367032 | 1 | 0 | GAD |
Hypobetalipoproteinemias | 0.001357209 | 5 | 0 | BeFree |
Familial hypobetalipoproteinemia | 0.000814326 | 3 | 0 | BeFree |
Arteriosclerosis | 0.000542884 | 2 | 0 | BeFree |
Atherosclerosis | 0.000542884 | 2 | 0 | BeFree |
Diabetes | 0.000542884 | 2 | 0 | BeFree |
Diabetes Mellitus | 0.000542884 | 2 | 0 | BeFree |
Hyperlipidemia | 0.000542884 | 2 | 0 | BeFree |
Obesity | 0.000542884 | 2 | 0 | BeFree |
Metabolic Syndrome X | 0.000542884 | 2 | 0 | BeFree |
Cardiovascular Diseases | 0.000271442 | 1 | 0 | BeFree |
Fatty Liver | 0.000271442 | 1 | 0 | BeFree |
Hyperinsulinism | 0.000271442 | 1 | 0 | BeFree |
Metabolic Diseases | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of mouth | 0.000271442 | 1 | 0 | BeFree |
Lip and Oral Cavity Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Hypotriglyceridaemia | 0.000271442 | 1 | 0 | BeFree |
Opitz trigonocephaly syndrome | 0.000271442 | 1 | 0 | BeFree |
Ischemic stroke | 0.000271442 | 1 | 3 | BeFree |
Ischemic Cerebrovascular Accident | 0.000271442 | 1 | 3 | BeFree |
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