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This gene encodes an enzyme involved in the converstion of arachidonic acid to 12R-hydroxyeicosatetraenoic acid. Mutations in this gene are associated with nonbullous congenital ichthyosiform erythroderma. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  该基因编码参与花生四烯酸的converstion到12R-羟酸的酶。在这种基因突变与nonbullous先天性鱼鳞癣红皮相关联。 [由RefSeq的,2008年7月提供]
ALOX12B基因(以及对应的蛋白质)的细胞分布位置:
ALOX12B基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Congenital Nonbullous Ichthyosiform Erythroderma | 0.241628651 | 7 | 0 | BeFree_CTD_human_ORPHANET |
ICHTHYOSIFORM ERYTHRODERMA, CONGENITAL, NONBULLOUS, 1 | 0.24 | 0 | 13 | CLINVAR_CTD_human |
ICHTHYOSIS, CONGENITAL, AUTOSOMAL RECESSIVE 2 | 0.2 | 4 | 2 | MGD_UNIPROT |
Ichthyosiform Erythroderma, Congenital | 0.008358616 | 5 | 0 | BeFree_GAD_LHGDN |
Exfoliative dermatitis | 0.00272435 | 1 | 0 | LHGDN |
Malignant neoplasm of breast | 0.002367032 | 1 | 0 | GAD |
Cardiovascular Diseases | 0.002367032 | 1 | 0 | GAD |
Brain Ischemia | 0.002367032 | 1 | 0 | GAD |
Coronary heart disease | 0.002367032 | 1 | 0 | GAD |
Cerebrovascular accident | 0.002367032 | 1 | 0 | GAD |
Epithelial ovarian cancer | 0.002367032 | 1 | 0 | GAD |
Congenital ichthyosis | 0.001628651 | 6 | 0 | BeFree |
Ichthyoses | 0.000814326 | 3 | 0 | BeFree |
Squamous cell carcinoma | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of lung | 0.000271442 | 1 | 0 | BeFree |
Carcinoma of lung | 0.000271442 | 1 | 0 | BeFree |
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