ALAS1(5'-aminolevulinate synthase 1) 转至新版数据库

基因基本信息

基因基本信息

基因简称(symbol)
    [HGNC]     [GeneCards]     [NCBI]
基因种类(locus group)
同源简称(alias symbol)
基因家族代码(gene_family_id)
    [HGNC]     [GenScript]
omim代码
entrez码
    [Vega]
vega基因码
ensembl基因码
    [Ensembl]
基因家族(gene family)
refseq数据库代号

更多...

基因种类(locus_type)
基因名称状态(status)
location_sortable
同源基因名称(alias name)
基因名称批准使用时间(date_approved_reserved)
基因简称更名时间(date_symbol_changed)
基因名称更名时间(date_name_changed)
更新时间(date_modified)
ucsc码
ena
ccds数据码
uniprot数据码
pubmed代码
mgd码
rgd码
生命科学数据库(lsdb)
更新时间(date modified)
cosmic
mirbase
基因曾用简称(prev symbol)
基因曾用名称(prev name)
homeodb
cosmic
snornabase
bioparadigms slc
orphanet
假基因信息(pseudogeneorg)
horde id
merops
imgt
iuphar
kznf基因类别
mamit-trnadb
cd
LncRNA数据库
酶代码
中间纤维数据库

收起

基因染色体位置

基因染色体位置

3p21
基因染色体位置图

基因简述

基因简述

This gene encodes the mitochondrial enzyme which is catalyzes the rate-limiting step in heme (iron-protoporphyrin) biosynthesis. The enzyme encoded by this gene is the housekeeping enzyme; a separate gene encodes a form of the enzyme that is specific for erythroid tissue. The level of the mature encoded protein is regulated by heme: high levels of heme down-regulate the mature enzyme in mitochondria while low heme levels up-regulate. A pseudogene of this gene is located on chromosome 12. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2015]

[中文简述(自动翻译):]  该基因编码线粒体酶是催化血红素的限速步骤（铁原卟啉）的生物合成。由该基因编码的酶是看家酶;一个单独的基因编码特异于红细胞组织的酶的形式。成熟编码的蛋白质的水平通过血红素调节：高含量的血红素的线粒体下调成熟酶而低血红素水平上调。这个基因的假基因位于染色体12中的多个转录物剪接的结果变体编码不同同种型。 [由RefSeq的，2015年1月提供]

OMIM数据库中对ALAS1基因的介绍     Wikipedia数据库中对ALAS1基因的介绍

基因序列

基因序列

ALAS1基因的碱基序列：[NCBI]

基因突变

基因突变

ALAS1基因的碱基突变：           显示全部snp
rs104902       rs104903       rs164640       rs164641       rs181274       rs352163       rs352164       rs352165       rs352166       rs352167       rs352168       rs352169       rs352170       rs352171       rs709315       rs3216487       rs4687815       rs6763732       rs6802320       rs7644241       rs9813448       rs9813468       rs9827239       rs11712164       rs11716756       rs13064414       rs17052017       rs17052020       rs35338461       rs57860290       rs59820555       rs60097954       rs60539053       rs61729067       rs61729068       rs71297385       rs72955285      
rs72955288       rs72955290       rs72955292       rs72959305       rs73835710       rs73835711       rs73835712       rs74956049       rs75207155       rs75704595       rs76005311       rs76458767       rs76506183       rs77223931       rs77854482       rs78041309       rs78520106       rs78617635       rs111251324       rs111415383       rs111428372       rs111705267       rs111868598       rs112154553       rs112304502       rs112408499       rs112660331       rs112808934       rs112815516       rs113136925       rs113370276       rs113510219       rs113592302       rs114033185       rs114270077       rs114545671       rs115309848       rs115661299       rs115904742       rs116013506       rs116017578       rs116535703       rs117730410       rs138113976       rs138208474       rs138392008       rs138459596       rs138494682       rs138819992       rs138922632       rs138925874       rs139176899       rs139865127       rs139914359       rs140282860       rs140581739       rs140582251       rs141182569       rs141245704       rs141433463       rs141435391       rs141440846       rs142009485       rs142401935       rs142487265       rs142561243       rs142690702       rs142791745       rs142835980       rs142841088       rs142895395       rs143204062       rs143326561       rs143412623       rs143432678       rs143479698       rs143531630       rs143805645       rs144022954       rs144075472       rs144121026       rs144166227       rs144285500       rs144295003       rs144316660       rs144527701       rs144563489       rs144652885       rs144662414       rs144889433       rs144906218       rs144941742       rs145553963       rs145651843       rs145784344       rs145803672       rs145807898       rs145966605       rs146085862       rs146105422       rs146474312       rs146482105       rs147060019       rs147338725       rs147341673       rs147513353       rs147777160       rs147806996       rs148064358       rs148351631       rs148466635       rs148510269       rs148711657       rs148715618       rs148819009       rs148992702       rs149519674       rs149791967       rs149960347       rs150267006       rs150267990       rs150321206       rs150493561       rs150596621       rs150778110       rs150828800       rs150864375       rs150932815       rs150952302       rs151137611       rs151190937       rs180746150       rs180908426       rs181177787       rs181235825       rs181637424       rs181665647       rs181728263       rs181915759       rs182084974       rs182376356       rs182395582       rs182594700       rs182778936       rs182957480       rs183093852       rs183372382       rs183524615       rs183533237       rs183571513       rs184013405       rs184014865       rs184166103       rs184338746       rs184602790       rs184857403       rs185228694       rs185493329       rs185535407       rs185836279       rs185860301       rs186410635       rs186512153       rs186571980       rs186692227       rs186870556       rs187258001       rs187348260       rs187484828       rs187586746       rs187600424       rs188009730       rs188660090       rs189001590       rs189036737       rs189183702       rs189560195       rs189657494       rs189664844       rs190033525       rs190077748       rs190315870       rs190341217       rs190405069       rs190646645       rs191109889       rs191139903       rs191206051       rs191316538       rs191728871       rs191761670       rs191917456       rs192400385       rs192613297       rs192640522       rs192796173       rs192989030       rs193022100       rs199507022       rs199511435       rs199609023       rs199715564       rs199908611       rs199979607       rs200197258       rs200361165       rs200534996       rs200580826       rs200675050       rs200922726       rs201007607       rs201312610       rs201359123       rs201457785       rs201589905       rs201857497       rs202007599       rs202018452       rs202046650       rs202085897       rs202174005       rs367708093       rs367967930       rs368106581       rs368113214       rs368153991       rs368539225       rs368742565       rs368746086       rs369138885       rs369540535       rs369759331       rs369797960       rs369808123       rs369979131       rs370171958       rs370237416       rs370365062       rs370488703       rs370684990       rs370937010       rs371101852       rs371130714       rs371320771       rs371325389       rs371351244       rs371792082       rs371824032       rs371850260       rs371924643       rs372253306       rs372500669       rs372617767       rs372992424       rs373053276       rs373367148       rs373873328       rs374072823       rs374074279       rs374158465       rs374159410       rs374184871       rs374350421       rs374359979       rs374639455       rs374909536       rs375063752       rs375562725       rs375898725       rs376130034       rs376223208       rs376464032       rs376547809       rs377356030       rs377535243       rs377569035       rs527345323       rs527347164       rs527407581       rs527889142       rs527948130       rs528012198       rs528014399       rs528210304       rs528292587       rs528420052       rs528585181       rs528869334       rs528935323       rs528959013       rs529109497       rs529250224       rs529309571       rs529309778       rs529411963       rs530318296       rs530365868       rs530727954       rs530800696       rs531202643       rs531330631       rs531742452       rs531998013       rs532077701       rs532137648       rs532255744       rs532328838       rs532357636       rs532405889       rs532870382       rs532943804       rs533149776       rs533270163       rs533357565       rs533664800       rs533723527       rs533785697       rs533844689       rs534247819       rs534586715       rs535066749       rs535070934       rs535433738       rs535495485       rs535642305       rs535702035       rs535788640       rs536028784       rs536095758       rs536622357       rs536971176       rs537092390       rs537630597       rs537633642       rs537903202       rs537913781       rs538105267       rs538486343       rs538944262       rs539016860       rs539487648       rs539507190       rs539625917       rs539689667       rs540007263       rs540147992       rs540171172       rs540270126       rs540568409       rs540601905       rs540664001       rs541551285       rs541614525       rs541762874       rs541899178       rs541962284       rs542021979       rs542023973       rs542049947       rs542087187       rs542132979       rs542634544       rs542761051       rs542820216       rs542997026       rs543575528       rs543700899       rs544003785       rs544010795       rs544072895       rs544100623       rs544109603       rs544123932       rs544170354       rs544253941       rs544378400       rs544577614       rs545057561       rs545245572       rs545431684       rs545491566       rs545588878       rs545654349       rs545925915       rs546056377       rs546100415       rs546128292       rs546242023       rs546644306       rs546690561       rs546716411       rs546755808       rs547093902       rs547157116       rs547218507       rs548048686       rs548508126       rs548531018       rs548570819       rs548916747       rs548993998       rs549009479       rs549071088       rs549197744       rs549406928       rs549582981       rs549680345       rs549741787       rs549885441       rs549981434       rs550732223       rs550902916       rs550966202       rs551063569       rs551184972       rs551392845       rs551785183       rs551924229       rs551985692       rs552103144       rs552124142       rs552226658       rs552260321       rs552446703       rs553115296       rs553580829       rs554100395       rs554153659       rs554289782       rs554507692       rs555032394       rs555228065       rs555356019       rs555509993       rs555556588       rs555635384       rs556607129       rs556706273       rs557491304       rs557567718       rs557621350       rs557629162       rs557683781       rs557897094       rs557958856       rs558085055       rs558185824       rs558426001       rs559017238       rs559391575       rs560070888       rs560101710       rs560572187       rs560866157       rs561210997       rs561485931       rs561610222       rs561824801       rs561951108       rs562566359       rs562600930       rs562627448       rs562826616       rs562890825       rs563106366       rs563290940       rs563352888       rs563875298       rs563930914       rs564152925       rs564213724       rs564339135       rs564394089       rs564555400       rs564680034       rs565224492       rs565429731       rs565431223       rs565493449       rs565554364       rs565863280       rs565960064       rs566087284       rs566415278       rs566484111       rs566594592       rs566732959       rs566792921       rs566938690       rs567133009       rs567147376       rs567421407       rs567464550       rs568005929       rs568127714       rs568650946       rs568882551       rs569035874       rs569059062       rs569892515       rs570377038       rs570528383       rs570651290       rs570708793       rs570715604       rs570840549       rs570898661       rs570901391       rs571052407       rs571115407       rs571175682       rs571238246       rs571702332       rs571888687       rs571948151       rs572673557       rs572734361       rs572952395       rs573054755       rs573171904       rs573233068       rs573352794       rs573400271       rs573573202       rs573632345       rs573698006       rs574375069       rs574479576       rs574603412       rs574961262       rs574976435       rs574996724       rs575411680       rs575449991       rs575461106       rs575570590       rs576640072       rs576702760       rs576769101       rs576778810       rs576945896       rs577040782       rs577432514       rs577482290       rs577495398       rs577544636       rs577838665       rs578160056       rs745368562       rs745382348       rs745398631       rs745478838       rs745625898       rs745760920       rs745922702       rs745994259       rs746150701       rs746235522       rs746242689       rs746247203       rs746496864       rs746524422       rs746726887       rs746764742       rs746810999       rs746899233       rs746899289       rs747058270       rs747090477       rs747182152       rs747345401       rs747571645       rs747629001       rs747721605       rs747852115       rs747886518       rs747947645       rs748075827       rs748222418       rs748243031       rs748651142       rs748813370       rs748905046       rs749168022       rs749294843       rs749325895       rs749343174       rs749484864       rs749512727       rs749651370       rs749742771       rs749744738       rs749968353       rs750118705       rs750206823       rs750222096       rs750392406       rs750408882       rs750459005       rs750662817       rs750696496       rs751005710       rs751352924       rs751369317       rs751664851       rs751676183       rs751683606       rs751814469       rs752086863       rs752178982       rs752394533       rs752454707       rs752460706       rs752482284       rs752572825       rs752732114       rs752811688       rs752999300       rs753008589       rs753135678       rs753188556       rs753288503       rs753295410       rs753485350       rs753520796       rs753605880       rs753607025       rs753766371       rs753933485       rs754099976       rs754231581       rs754580220       rs754596980       rs754787735       rs754877016       rs754983866       rs755148387       rs755309775       rs755379651       rs755401759       rs755435840       rs755538845       rs755727684       rs755815788       rs755879742       rs755982793       rs756023592       rs756204390       rs756259910       rs756347920       rs756383757       rs756515441       rs756830605       rs756926010       rs757085526       rs757206838       rs757222865       rs757350294       rs757367767       rs757391785       rs757443978       rs757455604       rs757532535       rs757638381       rs757700214       rs757982040       rs758000488       rs758008458       rs758068550       rs758227883       rs758345189       rs758616504       rs758632913       rs758758646       rs758772160       rs758776575       rs758864370       rs758943733       rs758970433       rs759033636       rs759060175       rs759176551       rs759233006       rs759342642       rs759462446       rs759621720       rs759713207       rs759796293       rs760051300       rs760113384       rs760203277       rs760492620       rs760777659       rs760798815       rs761131297       rs761204065       rs761283191       rs761371261       rs761373222       rs761391804       rs761619270       rs761715965       rs761933930       rs762046014       rs762050719       rs762233246       rs762323162       rs762339615       rs762345744       rs762349397       rs762430327       rs762435649       rs762814249       rs762814321       rs762970207       rs763046598       rs763108477       rs763198624       rs763206105       rs763479689       rs763497957       rs763546498       rs763613138       rs763707326       rs763836205       rs764042272       rs764106762       rs764123354       rs764210286       rs764383337       rs764477939       rs764667191       rs764757033       rs764853391       rs765170135       rs765216172       rs765260080       rs765278013       rs765375245       rs765444244       rs765468923       rs765596796       rs765877092       rs765911192       rs765950924       rs766037050       rs766041642       rs766417411       rs766493092       rs766578972       rs766685181       rs766975956       rs767065228       rs767175405       rs767305562       rs767362905       rs767491612       rs767700643       rs768041322       rs768131180       rs768132963       rs768155440       rs768454292       rs768458097       rs768475681       rs768498244       rs768548856       rs768669096       rs768767865       rs768818661       rs769009317       rs769075509       rs769089852       rs769097330       rs769179705       rs769557806       rs769576349       rs769576350       rs769653616       rs769662941       rs769664174       rs769758609       rs769923499       rs769934281       rs770052196       rs770274022       rs770294028       rs770321717       rs770386748       rs770620231       rs770713505       rs770756062       rs771092103       rs771205514       rs771251292       rs771364400       rs771454351       rs771527342       rs771754612       rs771777368       rs771789280       rs771803061       rs771887028       rs771938573       rs771982359       rs772176850       rs772358252       rs772455049       rs772468947       rs772498476       rs772610145       rs772625034       rs772639657       rs772729553       rs772777139       rs772796660       rs772838734       rs773177952       rs773216950       rs773262759       rs773558618       rs773622905       rs773733316       rs773796345       rs773948342       rs774202996       rs774285426       rs774390860       rs774412573       rs774777796       rs774794269       rs774892158       rs774896720       rs775005654       rs775075760       rs775368865       rs775368873       rs775456891       rs775458397       rs775573851       rs775821753       rs775885258       rs775898142       rs775911607       rs775968319       rs776044151       rs776120817       rs776164943       rs776189406       rs776213053       rs776322697       rs776492332       rs776530180       rs776605507       rs776623996       rs776712073       rs776862151       rs776951209       rs776991708       rs777078520       rs777283343       rs777502828       rs777664259       rs777752421       rs777870053       rs777955397       rs777962219       rs778108290       rs778316387       rs778337149       rs778395589       rs778404140       rs778517268       rs778599796       rs778676420       rs778698812       rs778724783       rs779005223       rs779009528       rs779095573       rs779110321       rs779251034       rs779360458       rs779391579       rs779530454       rs779673746       rs779835094       rs779917647       rs779922896       rs780098386       rs780151880       rs780264478       rs780318962       rs780502682       rs780513566       rs780609581       rs780836682       rs780866321       rs780928694       rs781058627       rs781276177       rs781372666       rs781534308      

基因表达

基因表达

ALAS1基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向引物Tm值
反向引物序列
反向引物Tm值
rank
TTCAATGGATGGCAAAGCC
59
CATAGGACCGTACGGTGTC
60
TTCAATGGATGGCAAAGCC
59
GTGAAGATGAAGCCAGCAG
59
AGTGTCTTCTGCAAAGCCA
60
GGTTTCAGCAACCTCTTTCC
60
CAGTGTCTTCTGCAAAGCC
60
GGTTTCAGCAACCTCTTTCC
60
CAGATGCTAATGGATGCCG
59
TAGTTCATCACAGACTTCTGTG
58
ATTCAATGGATGGCAAAGCC
60
CATAGGACCGTACGGTGTC
60
ACAGATGCTAATGGATGCC
57
TTTAGCAGCATCTGCAACC
58
GACAGATGCTAATGGATGCC
58
TTTAGCAGCATCTGCAACC
58
CAGTGTCTTCTGCAAAGCC
60
GTTTCAGCAACCTCTTTCCTC
60
CAGATGCTAATGGATGCCG
58
TTTAGCAGCATCTGCAACC
58

转录因子

转录因子

      尚未收录相关数据

基因本体信息

ALAS1基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 溶酶体
  • 内涵体
  • 细胞核
  • 细胞质
  • 液泡
  • 细胞膜
  • 细胞外基质
  • 内质网
  • 线粒体
  • 高尔基体
  • 细胞骨架

ALAS1基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0003824
H7C4H7(UniProtKB)
IEA
GO:0009058
H7C4H7(UniProtKB)
IEA
GO:0030170
H7C4H7(UniProtKB)
IEA
GO:0003824
H7C5B0(UniProtKB)
IEA
GO:0009058
H7C5B0(UniProtKB)
IEA
GO:0030170
H7C5B0(UniProtKB)
IEA
GO:0003870
P13196(UniProtKB)
TAS
GO:0005515
P13196(UniProtKB)
IPI
GO:0005515
P13196(UniProtKB)
IPI
GO:0005515
P13196(UniProtKB)
IPI
GO:0005515
P13196(UniProtKB)
IPI
GO:0005515
P13196(UniProtKB)
IPI
GO:0005515
P13196(UniProtKB)
IPI
GO:0005515
P13196(UniProtKB)
IPI
GO:0005515
P13196(UniProtKB)
IPI
GO:0005515
P13196(UniProtKB)
IPI
GO:0005515
P13196(UniProtKB)
IPI
GO:0005515
P13196(UniProtKB)
IPI
GO:0005515
P13196(UniProtKB)
IPI
GO:0005515
P13196(UniProtKB)
IPI
GO:0005515
P13196(UniProtKB)
IPI
GO:0005515
P13196(UniProtKB)
IPI
GO:0005515
P13196(UniProtKB)
IPI
GO:0005515
P13196(UniProtKB)
IPI
GO:0005515
P13196(UniProtKB)
IPI
GO:0005515
P13196(UniProtKB)
IPI
GO:0005515
P13196(UniProtKB)
IPI
GO:0005515
P13196(UniProtKB)
IPI
GO:0005515
P13196(UniProtKB)
IPI
GO:0005515
P13196(UniProtKB)
IPI
GO:0005515
P13196(UniProtKB)
IPI
GO:0005515
P13196(UniProtKB)
IPI
GO:0005515
P13196(UniProtKB)
IPI
GO:0005515
P13196(UniProtKB)
IPI
GO:0005515
P13196(UniProtKB)
IPI
GO:0005515
P13196(UniProtKB)
IPI
GO:0005654
P13196(UniProtKB)
IDA
GO:0005737
P13196(UniProtKB)
IDA
GO:0005739
P13196(UniProtKB)
IDA
GO:0005759
P13196(UniProtKB)
TAS
GO:0005759
P13196(UniProtKB)
TAS
GO:0006782
P13196(UniProtKB)
IEA
GO:0006783
P13196(UniProtKB)
TAS
GO:0007005
P13196(UniProtKB)
TAS
GO:0030170
P13196(UniProtKB)
IEA

基因相互作用关系

基因相互作用关系

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因相关microRNA

基因相关microRNA

可能调控ALAS1基因的相关microRNA：     

基因通路图

基因通路图

基因的通路属性图
通路基因列表

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Disorders of Porphyrin Metabolism 0.2 2 0 CTD_human_RGD
Diabetes Mellitus, Experimental 0.08 1 0 RGD
Pulmonary Hypertension 0.08 1 0 RGD
Rhabdomyolysis 0.08 1 0 RGD
Sepsis 0.08 1 0 RGD
Sideroblastic anemia 0.003267234 3 0 BeFree_LHGDN
Liver Failure, Acute 0.002995792 1 0 BeFree_LHGDN
Acute intermittent porphyria 0.001085767 4 0 BeFree
Hereditary sideroblastic anemia 0.000542884 2 0 BeFree
Diabetes 0.000271442 1 0 BeFree
Diabetes Mellitus 0.000271442 1 0 BeFree
Liver neoplasms 0.000271442 1 0 BeFree
Erythropoietic Protoporphyria 0.000271442 1 0 BeFree
Gallbladder Carcinoma 0.000271442 1 0 BeFree
Microcytic hypochromic anemia (disorder) 0.000271442 1 0 BeFree
Malignant neoplasm of prostate 0.000271442 1 0 BeFree
Prostate carcinoma 0.000271442 1 0 BeFree
Liver carcinoma 0.000271442 1 0 BeFree

基因相关文献

基因相关文献

基因相关服务

基因相关服务

基因评论

基因评论

我要说两句
热门评论
还没有评论，赶快来抢沙发吧。

登陆

用户名:

密    码:

联系方式

山东省济南市 高新区 崇华路359号 三庆世纪财富中心C1115室

电话： 0531-88819269

E-mail: product@genelibs.com

微信公众号

扫一扫右方二维码，关注微信订阅号，实时查看信息，关注医学生物学动态。

版权所有 © 2016.Genelibs 济南弘晖生物技术有限公司 鲁ICP备13024435号-2