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This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the bioreduction of chlordecone, a toxic organochlorine pesticide, to chlordecone alcohol in liver. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  该基??因编码的醛/酮还原酶家族,其由超过40已知酶和蛋白质的成员。这些酶利用NADH和/或NADPH作为辅因子催化的醛和酮,以它们相应的醇的转化。酶显示重叠但不同的底物特异性。这种酶催化十氯酮在肝脏的生物还原,一种有毒的有机氯农药,十氯酮醇。该基因股与其他三个成员的基因序列高度认同,并在染色体10p15-P14是集群与三个基因。 [由RefSeq的,2008年7月提供]
AKR1C4基因(以及对应的蛋白质)的细胞分布位置:
AKR1C4基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
MALE PSEUDOHERMAPHRODITISM: DEFICIENCY OF TESTICULAR 17,20-DESMOLASE | 0.24 | 0 | 1 | CLINVAR_ORPHANET |
Bipolar Disorder | 0.120542884 | 2 | 0 | BeFree_CTD_human |
Paranoia | 0.120271442 | 1 | 0 | BeFree_CTD_human |
Presenile dementia | 0.003257302 | 12 | 5 | BeFree |
Dementia | 0.003257302 | 12 | 5 | BeFree |
Alcoholic Intoxication, Chronic | 0.002638474 | 2 | 0 | BeFree_GAD |
Malignant neoplasm of urinary bladder | 0.002638474 | 2 | 1 | BeFree_GAD |
Malignant neoplasm of breast | 0.002638474 | 2 | 0 | BeFree_GAD |
Chronic Obstructive Airway Disease | 0.002367032 | 1 | 0 | GAD |
Malignant neoplasm of lung | 0.002367032 | 1 | 0 | GAD |
Impaired cognition | 0.001357209 | 5 | 0 | BeFree |
Mild cognitive disorder | 0.001357209 | 5 | 0 | BeFree |
Alzheimer's Disease | 0.000814326 | 3 | 0 | BeFree |
Chronic Lymphocytic Leukemia | 0.000814326 | 3 | 0 | BeFree |
Cerebellar degeneration | 0.000814326 | 3 | 0 | BeFree |
Mild dementia | 0.000814326 | 3 | 5 | BeFree |
HIV Infections | 0.000542884 | 2 | 0 | BeFree |
Leukemia, Myelocytic, Acute | 0.000542884 | 2 | 0 | BeFree |
Manic | 0.000542884 | 2 | 0 | BeFree |
Congenital Abnormality | 0.000271442 | 1 | 0 | BeFree |
Bacterial Infections | 0.000271442 | 1 | 0 | BeFree |
Kartagener Syndrome | 0.000271442 | 1 | 0 | BeFree |
Lymphoma, Follicular | 0.000271442 | 1 | 0 | BeFree |
Multiple Myeloma | 0.000271442 | 1 | 0 | BeFree |
Myocardial Infarction | 0.000271442 | 1 | 0 | BeFree |
Polycythemia Vera | 0.000271442 | 1 | 0 | BeFree |
Preleukemia | 0.000271442 | 1 | 0 | BeFree |
Cerebrovascular accident | 0.000271442 | 1 | 0 | BeFree |
Progressive supranuclear palsy | 0.000271442 | 1 | 0 | BeFree |
Thrombocythemia, Essential | 0.000271442 | 1 | 0 | BeFree |
Virus Diseases | 0.000271442 | 1 | 0 | BeFree |
Lymphoma, AIDS-Related | 0.000271442 | 1 | 0 | BeFree |
Neurofibrillary degeneration (morphologic abnormality) | 0.000271442 | 1 | 0 | BeFree |
Cerebral atrophy | 0.000271442 | 1 | 0 | BeFree |
Hypomania | 0.000271442 | 1 | 0 | BeFree |
secondary myelofibrosis | 0.000271442 | 1 | 0 | BeFree |
Parkinsonian Disorders | 0.000271442 | 1 | 0 | BeFree |
Senile Plaques | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of prostate | 0.000271442 | 1 | 0 | BeFree |
Prostate carcinoma | 0.000271442 | 1 | 0 | BeFree |
Breast Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Carcinoma of bladder | 0.000271442 | 1 | 1 | BeFree |
Paranoid ideation | 0.000271442 | 1 | 0 | BeFree |
Persistent infection | 0.000271442 | 1 | 0 | BeFree |
Cognitive changes | 0.000271442 | 1 | 0 | BeFree |
Mammographic Density | 0.000271442 | 1 | 0 | BeFree |
MYELODYSPLASTIC SYNDROME | 0.000271442 | 1 | 0 | BeFree |
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