AK1(adenylate kinase 1) 转至新版数据库

基因基本信息

基因基本信息

基因简称(symbol)
    [HGNC]     [GeneCards]     [NCBI]
基因种类(locus group)
同源简称(alias symbol)
基因家族代码(gene_family_id)
    [HGNC]     [GenScript]
omim代码
entrez码
    [Vega]
vega基因码
ensembl基因码
    [Ensembl]
基因家族(gene family)
refseq数据库代号

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基因种类(locus_type)
基因名称状态(status)
location_sortable
同源基因名称(alias name)
基因名称批准使用时间(date_approved_reserved)
基因简称更名时间(date_symbol_changed)
基因名称更名时间(date_name_changed)
更新时间(date_modified)
ucsc码
ena
ccds数据码
uniprot数据码
pubmed代码
mgd码
rgd码
生命科学数据库(lsdb)
更新时间(date modified)
cosmic
mirbase
基因曾用简称(prev symbol)
基因曾用名称(prev name)
homeodb
cosmic
snornabase
bioparadigms slc
orphanet
假基因信息(pseudogeneorg)
horde id
merops
imgt
iuphar
kznf基因类别
mamit-trnadb
cd
LncRNA数据库
酶代码
中间纤维数据库

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基因染色体位置

基因染色体位置

9q34.1
基因染色体位置图

基因简述

基因简述

Adenylate kinase is an enzyme involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate group among adinine nucleotides. Three isozymes of adenylate kinase have been identified in vertebrates, adenylate isozyme 1 (AK1), 2 (AK2) and 3 (AK3). AK1 is found in the cytosol of skeletal muscle, brain and erythrocytes, whereas AK2 and AK3 are found in the mitochondria of other tissues including liver and heart. AK1 was identified because of its association with a rare genetic disorder causing nonspherocytic hemolytic anemia where a mutation in the AK1 gene was found to reduce the catalytic activity of the enzyme. [provided by RefSeq, Jul 2008]

[中文简述(自动翻译):]  腺苷酸激酶是参与通过催化磷酸基团的adinine核苷酸之间的可逆转移调节细胞内腺嘌呤核苷酸组成的酶。腺苷酸激酶的三种同工酶已在脊椎动物已经确定，腺苷酸同工酶1（AK1），2（AK2）和3（AK3）。 AK1在骨骼肌，大脑和红细胞的胞浆中，而AK2和AK3其他组织，包括肝脏和心脏的线粒体中被发现。 AK1被确定，因为它与一种罕见的遗传病症引起nonspherocytic溶血性贫血，其中在AK1基因中的突变被发现，以减少酶的催化活性相关联的。 [由RefSeq的，2008年7月提供]

OMIM数据库中对AK1基因的介绍     Wikipedia数据库中对AK1基因的介绍

基因序列

基因序列

AK1基因的碱基序列：[NCBI]

基因突变

基因突变

AK1基因的碱基突变：           显示全部snp
rs4226       rs743537       rs743538       rs743539       rs743540       rs762490       rs913984       rs913985       rs913986       rs913987       rs913988       rs968463       rs1005362       rs1009935       rs1556246       rs2010640       rs2026822       rs2026823       rs2070689       rs2070690       rs2070691       rs2070692       rs2070693       rs2094332       rs2249308       rs2767395       rs2767397       rs2767398       rs2767399       rs2767401       rs3758321       rs3758322       rs3758323       rs3780661       rs3780662       rs3780663       rs4837199      
rs4837201       rs5900773       rs5900775       rs6478799       rs7018806       rs7031929       rs7032134       rs8192462       rs9919016       rs9919018       rs10760508       rs10987762       rs10987763       rs10987765       rs10987766       rs11288755       rs13288292       rs13288722       rs13290260       rs13302053       rs34340582       rs34359777       rs35061519       rs35709840       rs35902264       rs41305503       rs55880338       rs56169967       rs56263300       rs56276620       rs56780407       rs57275097       rs61464635       rs61741075       rs61741083       rs61742069       rs61743911       rs61743914       rs62587241       rs66510043       rs66583898       rs67145503       rs67496792       rs71497672       rs72616671       rs72752884       rs72752885       rs73602323       rs73602342       rs73669434       rs73669435       rs73669436       rs73669437       rs74522986       rs75041557       rs75080536       rs75214817       rs75503973       rs75715743       rs76402890       rs76626594       rs77306199       rs77648429       rs77787745       rs78111106       rs78181560       rs78405032       rs78915085       rs78993839       rs79093871       rs79267307       rs79358298       rs79904358       rs111270104       rs112005111       rs112080302       rs112080972       rs112167455       rs112403021       rs112824996       rs112855538       rs112909840       rs113229034       rs113387915       rs113457006       rs113544593       rs113569468       rs113650328       rs113762157       rs113852098       rs114264447       rs114313235       rs114398415       rs114445530       rs114914972       rs115153145       rs115263629       rs115397650       rs115665198       rs116301334       rs116313129       rs116396454       rs116527635       rs116628811       rs116797665       rs116976624       rs117372957       rs117417032       rs117680905       rs117753413       rs117798003       rs117803707       rs117934298       rs137853204       rs137853205       rs137941473       rs138065487       rs138296058       rs138798179       rs139144698       rs139356748       rs139396377       rs139524781       rs139541022       rs139982921       rs140001307       rs140092292       rs140492623       rs140513676       rs140966686       rs141223381       rs141248779       rs141815495       rs141933637       rs142241048       rs142319672       rs143171239       rs143734167       rs144131388       rs144171533       rs144799475       rs145006104       rs145431113       rs145455142       rs145476677       rs145582459       rs146320071       rs146485385       rs146875724       rs147192664       rs147616730       rs147762231       rs148160737       rs148465401       rs148619036       rs148633083       rs149147899       rs149341247       rs149713459       rs150064330       rs150225405       rs150398230       rs150452308       rs150701679       rs150716722       rs150770626       rs151213588       rs151266836       rs181378875       rs181578124       rs181693216       rs181694534       rs182437286       rs182510016       rs182574197       rs182801507       rs183104169       rs183463287       rs184233303       rs184236044       rs184549229       rs184594957       rs185015567       rs185838589       rs186149610       rs186179854       rs186337207       rs187001682       rs187270804       rs187948230       rs188732233       rs188938377       rs189027138       rs189253757       rs189264244       rs189408572       rs189481090       rs190164259       rs190595810       rs190970374       rs191183756       rs191736725       rs191902395       rs192232491       rs192314837       rs192567466       rs192787854       rs200079882       rs200084584       rs200341848       rs200905575       rs201099728       rs201169609       rs201189980       rs201419342       rs201453879       rs201458399       rs201689426       rs201971818       rs202074921       rs202106101       rs367599598       rs367727104       rs367792272       rs367901833       rs368299963       rs368421126       rs368671161       rs368912370       rs369103462       rs369560590       rs369787823       rs369944236       rs370153108       rs370170122       rs370179913       rs370619008       rs370638623       rs370906551       rs371118909       rs371157693       rs371166157       rs371547218       rs371575007       rs372237345       rs372248359       rs372509369       rs373170895       rs373209848       rs373262576       rs373354444       rs373709830       rs373982790       rs374460965       rs374508336       rs374588499       rs374909243       rs375122190       rs375179611       rs375333097       rs375517545       rs375653403       rs375689945       rs375709414       rs375921903       rs376237367       rs376265763       rs376298766       rs376684222       rs376719148       rs377145679       rs377177401       rs377419250       rs527306893       rs527364890       rs528235859       rs528369830       rs528441017       rs528442964       rs528486338       rs528559761       rs528668640       rs528697182       rs529624498       rs529658348       rs529721048       rs529794104       rs529856999       rs530009468       rs530072300       rs530072454       rs530601015       rs530816972       rs530826715       rs530844938       rs530965855       rs531396022       rs531909283       rs531966935       rs532006993       rs532065070       rs532067062       rs532127928       rs532412276       rs532489415       rs533255428       rs533265541       rs533352592       rs533442637       rs533637372       rs533794730       rs533931832       rs534000390       rs534192962       rs534267399       rs534596319       rs534852796       rs535102112       rs535167029       rs535521349       rs535995484       rs536119637       rs536209021       rs536465469       rs536662120       rs536667729       rs536724509       rs536782896       rs536854340       rs537077633       rs537198606       rs537261312       rs537323803       rs537788746       rs537853601       rs537978042       rs538145755       rs538250013       rs538395483       rs538398363       rs538461464       rs538594958       rs538871440       rs539108170       rs539132761       rs539171924       rs539299705       rs540060476       rs540175148       rs540240897       rs540630601       rs540816728       rs540973113       rs541341989       rs541621782       rs541690262       rs541826426       rs541883988       rs542537772       rs542730572       rs542914404       rs542995129       rs543017470       rs543139818       rs543245168       rs543662678       rs543684833       rs544363087       rs544422179       rs544491475       rs544726184       rs544887883       rs544949492       rs544985399       rs545612570       rs545629821       rs545853323       rs545916762       rs545952308       rs546137958       rs546556014       rs546882091       rs547239481       rs547299936       rs547373412       rs547802182       rs548111211       rs548292705       rs548308209       rs548363911       rs548371283       rs548425380       rs548627517       rs548952089       rs548988551       rs549113172       rs549501535       rs549563211       rs549576089       rs549662449       rs549677154       rs549723620       rs550697045       rs550761353       rs550929387       rs551149048       rs551391835       rs551474891       rs551745873       rs551825170       rs551949292       rs552139871       rs552407652       rs552488634       rs552598497       rs552660528       rs552688214       rs552926358       rs552987997       rs553120399       rs553183495       rs553420592       rs553861986       rs554120550       rs554792022       rs554795214       rs555057971       rs555325863       rs555453526       rs556062710       rs556064282       rs556082581       rs556521742       rs556595957       rs556649729       rs556840867       rs556964698       rs557189203       rs557252451       rs557535696       rs557722571       rs557842974       rs557893692       rs557897631       rs557921303       rs558114757       rs558447135       rs558447456       rs558979180       rs559035910       rs559259806       rs559464017       rs559475560       rs559538716       rs559738217       rs560200284       rs560498754       rs560585866       rs560644275       rs560651196       rs560661182       rs560706775       rs560778466       rs560924633       rs561376325       rs561972418       rs562043398       rs562439397       rs562739326       rs562927250       rs562990585       rs562990748       rs563017433       rs563052949       rs563055475       rs563183507       rs563652012       rs563744700       rs564196004       rs564256024       rs564380059       rs564502834       rs564621893       rs564770380       rs565533878       rs565590294       rs565899249       rs565959057       rs566057231       rs567100830       rs567158806       rs567260650       rs567302753       rs568355644       rs568375534       rs568841689       rs568903722       rs569421825       rs569481215       rs569782923       rs569875402       rs569938131       rs569997176       rs570169975       rs570454389       rs570691555       rs571320284       rs571321082       rs571327750       rs571968534       rs572587239       rs572851802       rs573257482       rs573543554       rs573595601       rs573677779       rs573815394       rs573850389       rs574011305       rs574030784       rs574107108       rs574115369       rs574244308       rs574303225       rs574789065       rs574966146       rs575072448       rs575202974       rs575538809       rs576014615       rs576589817       rs576790505       rs576922127       rs577125839       rs577581134       rs577754102       rs577850115       rs578082086       rs745471497       rs745510283       rs746011742       rs746099632       rs746291169       rs746336326       rs746380720       rs746592337       rs746682346       rs747156836       rs747441793       rs747527824       rs748356103       rs748504155       rs748786472       rs749173887       rs749431283       rs749438351       rs749754568       rs750003169       rs750048810       rs750245032       rs750337792       rs750642408       rs750899537       rs751000982       rs751190212       rs751366122       rs751629167       rs751806914       rs751978476       rs752194585       rs752380443       rs752425591       rs752647287       rs753177103       rs753457534       rs753753781       rs753794871       rs753808695       rs753934618       rs754761796       rs755038291       rs755057633       rs755076598       rs755458590       rs755673410       rs755977850       rs756560200       rs756703055       rs756778564       rs756817349       rs757069816       rs757082739       rs757397992       rs757487966       rs758239561       rs758497870       rs758543997       rs758869714       rs759169480       rs759365000       rs759711164       rs760235278       rs760459617       rs760514756       rs760524560       rs760661161       rs761049374       rs761271981       rs761274632       rs761415373       rs761562065       rs761804052       rs762507799       rs762906771       rs763200874       rs763718570       rs763961254       rs764253801       rs764274408       rs764795620       rs765024799       rs765054939       rs765150695       rs765240669       rs765324583       rs765767256       rs766113940       rs766152032       rs766170104       rs766269861       rs766671097       rs767348248       rs767491704       rs767658405       rs767893823       rs768082886       rs768188982       rs768549785       rs768602942       rs768691465       rs768770372       rs768926123       rs769428663       rs769429363       rs769503890       rs770058973       rs770141221       rs770394256       rs771514852       rs771551136       rs771589195       rs771620419       rs772546476       rs772645948       rs772775608       rs772821804       rs772874780       rs773049575       rs773287385       rs773386135       rs773666232       rs773795388       rs773827161       rs773854670       rs774424327       rs774432775       rs774452787       rs774523679       rs774684518       rs775684067       rs776062690       rs776386826       rs777188261       rs777322703       rs777387576       rs777818756       rs778040305       rs778212643       rs778698940       rs778785156       rs778822857       rs779066406       rs779192466       rs779381063       rs779439692       rs779559662       rs779955214       rs780008104       rs780043007       rs780303050       rs780427267       rs780476150       rs780530648       rs780608421       rs780711229       rs780800760       rs781091960       rs781579568       rs781654996       rs781699153       rs869258373       rs562043398      

基因表达

基因表达

AK1基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向引物Tm值
反向引物序列
反向引物Tm值
rank
CTGGTTCCACTGGAGACAG
59
ATCAATCAGGAAGCCTTTGGA
59
CTGGTTCCACTGGAGACAG
59
CATCAATCAGGAAGCCTTTGG
59
CTGGTTCCACTGGAGACAG
59
TCAATCAGGAAGCCTTTGGA
59
TTTGTGGTGGGAGACAGTG
59
ATCAATCAGGAAGCCTTTGGA
59
TTTGTGGTGGGAGACAGTG
59
TCAATCAGGAAGCCTTTGGA
59
TCTTTGTGGTGGGAGACAG
59
TCAATCAGGAAGCCTTTGGA
59

转录因子

转录因子

      尚未收录相关数据

基因本体信息

AK1基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 溶酶体
  • 内涵体
  • 细胞核
  • 细胞质
  • 液泡
  • 细胞膜
  • 细胞外基质
  • 内质网
  • 线粒体
  • 高尔基体
  • 细胞骨架

AK1基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0005524
H0Y4J6(UniProtKB)
IEA
GO:0006139
H0Y4J6(UniProtKB)
IEA
GO:0016310
H0Y4J6(UniProtKB)
IEA
GO:0019205
H0Y4J6(UniProtKB)
IEA
GO:0005524
H0YID2(UniProtKB)
IEA
GO:0006139
H0YID2(UniProtKB)
IEA
GO:0016310
H0YID2(UniProtKB)
IEA
GO:0019205
H0YID2(UniProtKB)
IEA
GO:0001520
P00568(UniProtKB)
IEA
GO:0004017
P00568(UniProtKB)
EXP
GO:0004017
P00568(UniProtKB)
EXP
GO:0004550
P00568(UniProtKB)
IDA
GO:0005524
P00568(UniProtKB)
IEA
GO:0005737
P00568(UniProtKB)
IDA
GO:0005829
P00568(UniProtKB)
TAS
GO:0005829
P00568(UniProtKB)
TAS
GO:0005886
P00568(UniProtKB)
IEA
GO:0006165
P00568(UniProtKB)
IDA
GO:0006172
P00568(UniProtKB)
IEA
GO:0007050
P00568(UniProtKB)
IEA
GO:0009142
P00568(UniProtKB)
IDA
GO:0015949
P00568(UniProtKB)
TAS
GO:0046033
P00568(UniProtKB)
IEA
GO:0046034
P00568(UniProtKB)
IEA
GO:0070062
P00568(UniProtKB)
IDA
GO:0070062
P00568(UniProtKB)
IDA
GO:0004017
Q5T9B7(UniProtKB)
IEA
GO:0004550
Q5T9B7(UniProtKB)
IEA
GO:0005524
Q5T9B7(UniProtKB)
IEA
GO:0005737
Q5T9B7(UniProtKB)
IDA
GO:0006165
Q5T9B7(UniProtKB)
IEA
GO:0006172
Q5T9B7(UniProtKB)
IEA
GO:0009142
Q5T9B7(UniProtKB)
IEA
GO:0046033
Q5T9B7(UniProtKB)
IEA
GO:0046034
Q5T9B7(UniProtKB)
IEA

基因相互作用关系

基因相互作用关系

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因相关microRNA

基因相关microRNA

可能调控AK1基因的相关microRNA：     

基因通路图

基因通路图

基因的通路属性图
通路基因列表

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Adenylate Kinase Deficiency, Hemolytic Anemia Due To 0.48 3 8 CLINVAR_CTD_human_ORPHANET_UNIPROT
Myocardial Ischemia 0.12 1 0 CTD_human
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse 0.12 1 0 CTD_human
Diabetes Mellitus, Non-Insulin-Dependent 0.08 1 0 RGD
Infarction, Middle Cerebral Artery 0.08 1 0 RGD
Sarcopenia 0.08 1 0 RGD
Chronic hemolytic anemia 0.004734064 2 0 GAD
Schizophrenia 0.00272435 1 0 LHGDN
Fetal Growth Retardation 0.002367032 1 0 GAD
Deficiency of adenylate kinase 0.000814326 3 0 BeFree
Anemia, Hemolytic 0.000542884 2 0 BeFree

基因相关文献

基因相关文献

基因相关服务

基因相关服务

基因评论

基因评论

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