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This gene is expressed only in the liver and the encoded protein is localized mostly in the peroxisomes, where it is involved in glyoxylate detoxification. Mutations in this gene, some of which alter subcellular targetting, have been associated with type I primary hyperoxaluria. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):] 该基因表达仅在肝脏和编码的蛋白质在过氧化物酶,它参与了乙醛酸解毒大多本地化。突变在该基因,其中的一些改变亚细胞目标定位,已经用I型原发性高草酸盐相关联。 [由RefSeq的,2008年7月提供]
AGXT基因(以及对应的蛋白质)的细胞分布位置:
AGXT基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Primary hyperoxaluria, type I | 0.579000931 | 73 | 167 | BeFree_CLINVAR_CTD_human_MGD_ORPHANET_UNIPROT |
Hypertensive disease | 0.011400559 | 42 | 11 | BeFree |
Primary Hyperoxaluria | 0.010616028 | 11 | 0 | BeFree_LHGDN |
Essential Hypertension | 0.004071628 | 15 | 0 | BeFree |
Hyperoxaluria | 0.003995683 | 7 | 0 | BeFree_GAD |
Liver carcinoma | 0.002442977 | 9 | 1 | BeFree |
Diabetes | 0.002171535 | 8 | 2 | BeFree |
Diabetes Mellitus | 0.002171535 | 8 | 2 | BeFree |
Kidney Failure | 0.002171535 | 8 | 0 | BeFree |
Asthma | 0.001900093 | 7 | 0 | BeFree |
Diabetes Mellitus, Non-Insulin-Dependent | 0.001900093 | 7 | 3 | BeFree |
Diabetic Nephropathy | 0.001900093 | 7 | 0 | BeFree |
Coronary Artery Disease | 0.001900093 | 7 | 0 | BeFree |
Kidney Calculi | 0.001628651 | 6 | 1 | BeFree |
Coronary Arteriosclerosis | 0.001357209 | 5 | 0 | BeFree |
Coronary heart disease | 0.001357209 | 5 | 0 | BeFree |
Kidney Failure, Chronic | 0.001357209 | 5 | 0 | BeFree |
Metabolic Diseases | 0.001357209 | 5 | 0 | BeFree |
Chronic kidney disease stage 5 | 0.001357209 | 5 | 0 | BeFree |
Kidney Diseases | 0.001085767 | 4 | 1 | BeFree |
Urolithiasis | 0.001085767 | 4 | 0 | BeFree |
Obesity | 0.000814326 | 3 | 0 | BeFree |
Cerebrovascular accident | 0.000814326 | 3 | 0 | BeFree |
Nephrolithiasis | 0.000814326 | 3 | 0 | BeFree |
Microalbuminuria | 0.000814326 | 3 | 0 | BeFree |
Alzheimer's Disease | 0.000542884 | 2 | 0 | BeFree |
Malignant neoplasm of breast | 0.000542884 | 2 | 0 | BeFree |
Renal Cell Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Cardiovascular Diseases | 0.000542884 | 2 | 0 | BeFree |
Eclampsia | 0.000542884 | 2 | 0 | BeFree |
Eczema | 0.000542884 | 2 | 0 | BeFree |
Hypercholesterolemia | 0.000542884 | 2 | 0 | BeFree |
Inflammatory Bowel Diseases | 0.000542884 | 2 | 0 | BeFree |
Inborn Errors of Metabolism | 0.000542884 | 2 | 0 | BeFree |
Myocardial Infarction | 0.000542884 | 2 | 0 | BeFree |
Respiratory Distress Syndrome, Adult | 0.000542884 | 2 | 0 | BeFree |
Left Ventricular Hypertrophy | 0.000542884 | 2 | 0 | BeFree |
Acute myocardial infarction | 0.000542884 | 2 | 0 | BeFree |
Malignant neoplasm of lung | 0.000542884 | 2 | 0 | BeFree |
Restenosis | 0.000542884 | 2 | 0 | BeFree |
pricking of skin | 0.000542884 | 2 | 0 | BeFree |
Metabolic Syndrome X | 0.000542884 | 2 | 0 | BeFree |
Breast Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Carcinoma of lung | 0.000542884 | 2 | 0 | BeFree |
Ischemic stroke | 0.000542884 | 2 | 0 | BeFree |
Chronic Kidney Diseases | 0.000542884 | 2 | 0 | BeFree |
NEPHROLITHIASIS, CALCIUM OXALATE | 0.000542884 | 2 | 1 | BeFree |
Ischemic Cerebrovascular Accident | 0.000542884 | 2 | 0 | BeFree |
Adenocarcinoma | 0.000271442 | 1 | 0 | BeFree |
Alcoholic Intoxication, Chronic | 0.000271442 | 1 | 0 | BeFree |
Cooley's anemia | 0.000271442 | 1 | 0 | BeFree |
Aneurysm | 0.000271442 | 1 | 0 | BeFree |
Anxiety Disorders | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of skin | 0.000271442 | 1 | 0 | BeFree |
Malignant tumor of cervix | 0.000271442 | 1 | 3 | BeFree |
Subacute Bacterial Endocarditis | 0.000271442 | 1 | 0 | BeFree |
Glioblastoma | 0.000271442 | 1 | 0 | BeFree |
Glycogen storage disease type II | 0.000271442 | 1 | 0 | BeFree |
Sensorineural Hearing Loss (disorder) | 0.000271442 | 1 | 0 | BeFree |
Hepatitis | 0.000271442 | 1 | 0 | BeFree |
Hepatitis A | 0.000271442 | 1 | 0 | BeFree |
Hepatitis B | 0.000271442 | 1 | 0 | BeFree |
Homocystinuria | 0.000271442 | 1 | 0 | BeFree |
Hereditary Sensory Autonomic Neuropathy, Type 1 | 0.000271442 | 1 | 0 | BeFree |
Hyperaldosteronism | 0.000271442 | 1 | 0 | BeFree |
leiomyosarcoma | 0.000271442 | 1 | 0 | BeFree |
Mitral Valve Prolapse Syndrome | 0.000271442 | 1 | 0 | BeFree |
Neoplasm Metastasis | 0.000271442 | 1 | 0 | BeFree |
Nephrotic Syndrome | 0.000271442 | 1 | 0 | BeFree |
Ovarian Diseases | 0.000271442 | 1 | 0 | BeFree |
Periodontitis | 0.000271442 | 1 | 0 | BeFree |
Polycystic Ovary Syndrome | 0.000271442 | 1 | 0 | BeFree |
Retinal Diseases | 0.000271442 | 1 | 0 | BeFree |
Turner Syndrome | 0.000271442 | 1 | 0 | BeFree |
Viral hepatitis | 0.000271442 | 1 | 0 | BeFree |
Tooth Loss | 0.000271442 | 1 | 0 | BeFree |
Ovarian Failure, Premature | 0.000271442 | 1 | 0 | BeFree |
Migraine Disorders | 0.000271442 | 1 | 0 | BeFree |
Cutaneous Melanoma | 0.000271442 | 1 | 0 | BeFree |
Hypertensive heart disease | 0.000271442 | 1 | 0 | BeFree |
Chronic glomerulonephritis | 0.000271442 | 1 | 3 | BeFree |
Migraine with Aura | 0.000271442 | 1 | 0 | BeFree |
Secondary hypertension | 0.000271442 | 1 | 0 | BeFree |
Atherosclerosis of aorta | 0.000271442 | 1 | 0 | BeFree |
Allergic asthma | 0.000271442 | 1 | 0 | BeFree |
pineoblastoma | 0.000271442 | 1 | 0 | BeFree |
Primary hyperoxaluria type 2 | 0.000271442 | 1 | 0 | BeFree |
Inflammatory Breast Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Cervix carcinoma | 0.000271442 | 1 | 3 | BeFree |
Bleeding ulcer | 0.000271442 | 1 | 0 | BeFree |
Generalized glycogen storage disease of infants | 0.000271442 | 1 | 0 | BeFree |
Chronic rejection of renal transplant | 0.000271442 | 1 | 0 | BeFree |
Maternal hypertension | 0.000271442 | 1 | 0 | BeFree |
Carotid Atherosclerosis | 0.000271442 | 1 | 0 | BeFree |
Carcinogenesis | 0.000271442 | 1 | 0 | BeFree |
Nephronophthisis | 0.000271442 | 1 | 0 | BeFree |
Familial Retinoblastoma | 0.000271442 | 1 | 0 | BeFree |
Heart Failure, Systolic | 0.000271442 | 1 | 0 | BeFree |
Left ventricular systolic dysfunction | 0.000271442 | 1 | 1 | BeFree |
Cauda Equina Paraganglioma | 0.000271442 | 1 | 0 | BeFree |
Hepatocarcinogenesis | 0.000271442 | 1 | 0 | BeFree |
Glioblastoma Multiforme | 0.000271442 | 1 | 0 | BeFree |
Non-Neoplastic Disorder | 0.000271442 | 1 | 0 | BeFree |
ABLEPHARON-MACROSTOMIA SYNDROME | 0.000271442 | 1 | 0 | BeFree |
Allergic rhinitis (disorder) | 0.000271442 | 1 | 0 | BeFree |
Crigler Najjar syndrome, type 2 | 0.000271442 | 1 | 0 | BeFree |
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