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The advanced glycosylation end product (AGE) receptor encoded by this gene is a member of the immunoglobulin superfamily of cell surface receptors. It is a multiligand receptor, and besides AGE, interacts with other molecules implicated in homeostasis, development, and inflammation, and certain diseases, such as diabetes and Alzheimer's disease. Many alternatively spliced transcript variants encoding different isoforms, as well as non-protein-coding variants, have been described for this gene (PMID:18089847). [provided by RefSeq, May 2011]
[中文简述(自动翻译):]  由该基因编码的高级糖基化终产物(AGE)受体是细胞表面受体的免疫球蛋白超家族中的一员。它是一个多配受体,而除了年龄,在稳态,开发和炎症牵连其他分子,和某些疾病,如糖尿病和阿尔茨海默氏病进行交互。许多可变剪接转录物变体编码不同同种型,以及非蛋白质编码变体,已经为这种基因(:18089847 PMID)中所述。 [由RefSeq的,2011年5月提供]
AGER基因(以及对应的蛋白质)的细胞分布位置:
AGER基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Atherosclerosis | 0.213992882 | 12 | 0 | BeFree_CTD_human_GAD_LHGDN_RGD |
Diabetic Angiopathies | 0.128987376 | 7 | 2 | BeFree_CTD_human_LHGDN |
Rheumatoid Arthritis | 0.128715934 | 6 | 0 | BeFree_CTD_human_LHGDN |
Pulmonary function (finding) | 0.124734064 | 3 | 1 | GAD_GWASCAT |
Inflammation | 0.12272435 | 2 | 0 | CTD_human_LHGDN |
Hyperglycemia | 0.120814326 | 4 | 0 | BeFree_CTD_human |
Pancreatic Diseases | 0.12 | 1 | 0 | CTD_human |
Lewy Body Disease | 0.12 | 1 | 0 | CTD_human |
Diabetes Mellitus, Non-Insulin-Dependent | 0.10445097 | 27 | 2 | BeFree_GAD_LHGDN_RGD |
Diabetic Retinopathy | 0.101613118 | 17 | 2 | BeFree_GAD_LHGDN_RGD |
Diabetic Nephropathy | 0.101070234 | 16 | 1 | BeFree_GAD_LHGDN_RGD |
Alzheimer's Disease | 0.095631465 | 7 | 1 | GAD_LHGDN_RGD |
Cerebrovascular accident | 0.088358616 | 5 | 2 | BeFree_GAD_LHGDN_RGD |
Cardiovascular Diseases | 0.086263026 | 5 | 0 | BeFree_LHGDN_RGD |
Degenerative polyarthritis | 0.085720142 | 4 | 0 | BeFree_LHGDN_RGD |
Brain Ischemia | 0.0854487 | 3 | 0 | LHGDN_RGD |
Myocardial Infarction | 0.082909916 | 4 | 0 | BeFree_GAD_RGD |
Colorectal Neoplasms | 0.08272435 | 2 | 0 | LHGDN_RGD |
Fibrosis | 0.08272435 | 2 | 0 | LHGDN_RGD |
Hypertensive disease | 0.080814326 | 4 | 2 | BeFree_RGD |
Albuminuria | 0.08 | 1 | 0 | RGD |
Aortic Diseases | 0.08 | 1 | 0 | RGD |
Asthma | 0.08 | 1 | 0 | RGD |
Carotid Artery Diseases | 0.08 | 1 | 0 | RGD |
Intracranial Aneurysm | 0.08 | 1 | 0 | RGD |
Transient Ischemic Attack | 0.08 | 1 | 0 | RGD |
Diabetes Mellitus, Experimental | 0.08 | 2 | 0 | RGD |
Gastrointestinal Diseases | 0.08 | 1 | 0 | RGD |
Hyperalgesia | 0.08 | 2 | 0 | RGD |
Pulmonary Hypertension | 0.08 | 1 | 0 | RGD |
Myocardial Reperfusion Injury | 0.08 | 1 | 0 | RGD |
Osteoporosis | 0.08 | 1 | 0 | RGD |
Periodontitis | 0.08 | 1 | 0 | RGD |
Pulmonary Fibrosis | 0.08 | 1 | 0 | RGD |
Respiratory Distress Syndrome, Adult | 0.08 | 1 | 0 | RGD |
Subarachnoid Hemorrhage | 0.08 | 1 | 0 | RGD |
Thromboangiitis Obliterans | 0.08 | 1 | 0 | RGD |
Tongue Neoplasms | 0.08 | 1 | 0 | RGD |
Uremia | 0.08 | 1 | 0 | RGD |
Erectile dysfunction | 0.08 | 1 | 0 | RGD |
Acute Lung Injury | 0.08 | 1 | 0 | RGD |
Hyperoxia | 0.08 | 2 | 0 | RGD |
Sepsis | 0.08 | 1 | 0 | RGD |
Lung Injury | 0.08 | 1 | 0 | RGD |
Peritoneal Fibrosis | 0.08 | 1 | 0 | RGD |
Infarction, Middle Cerebral Artery | 0.08 | 1 | 0 | RGD |
Diabetic Cardiomyopathies | 0.08 | 1 | 0 | RGD |
Coronary Artery Disease | 0.017150496 | 15 | 2 | BeFree_LHGDN |
Diabetes Mellitus, Insulin-Dependent | 0.008458305 | 8 | 2 | BeFree_GAD |
Pancreatic Neoplasm | 0.007815732 | 3 | 0 | GAD_LHGDN |
Complications of Diabetes Mellitus | 0.007815732 | 2 | 0 | GAD_LHGDN |
Diabetes Mellitus | 0.00706742 | 17 | 3 | BeFree_LHGDN |
Kidney Diseases | 0.006263026 | 5 | 0 | BeFree_LHGDN |
Squamous cell carcinoma | 0.0054487 | 2 | 0 | LHGDN |
Prostatic Neoplasms | 0.0054487 | 2 | 0 | LHGDN |
Psoriasis | 0.005091382 | 1 | 1 | GAD_LHGDN |
Neoplasm Metastasis | 0.003538676 | 4 | 0 | BeFree_LHGDN |
Chronic Obstructive Airway Disease | 0.003452799 | 5 | 0 | BeFree_GAD |
Coronary Arteriosclerosis | 0.003257302 | 12 | 2 | BeFree |
Diabetes | 0.003257302 | 12 | 3 | BeFree |
Adenocarcinoma | 0.002995792 | 2 | 0 | BeFree_LHGDN |
Lung Neoplasms | 0.002995792 | 2 | 0 | BeFree_LHGDN |
melanoma | 0.002995792 | 2 | 0 | BeFree_LHGDN |
Myocardial Ischemia | 0.002995792 | 1 | 0 | BeFree_LHGDN |
Non-Small Cell Lung Carcinoma | 0.002909916 | 2 | 0 | BeFree_GAD |
Amyloidosis | 0.00272435 | 1 | 0 | LHGDN |
Chondrosarcoma | 0.00272435 | 1 | 0 | LHGDN |
Cessation of life | 0.00272435 | 1 | 0 | LHGDN |
Dementia, Vascular | 0.00272435 | 1 | 0 | LHGDN |
Dermatomyositis | 0.00272435 | 1 | 0 | LHGDN |
Diabetic Ketoacidosis | 0.00272435 | 1 | 0 | LHGDN |
Diabetic Neuropathies | 0.00272435 | 1 | 0 | LHGDN |
Neuronal Ceroid-Lipofuscinoses | 0.00272435 | 1 | 0 | LHGDN |
Rhabdomyosarcoma | 0.00272435 | 1 | 0 | LHGDN |
Sarcoidosis | 0.00272435 | 1 | 0 | LHGDN |
Tuberculosis | 0.00272435 | 1 | 0 | LHGDN |
Polymyositis | 0.00272435 | 1 | 0 | LHGDN |
Impaired glucose tolerance | 0.00272435 | 1 | 0 | LHGDN |
Mammary Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
Sjogren's Syndrome | 0.00272435 | 1 | 0 | LHGDN |
Idiopathic Pulmonary Fibrosis | 0.00272435 | 1 | 0 | LHGDN |
Coronary heart disease | 0.002714419 | 10 | 2 | BeFree |
Lung diseases | 0.002638474 | 2 | 0 | BeFree_GAD |
Ulcerative Colitis | 0.002367032 | 1 | 0 | GAD |
Kidney Failure, Chronic | 0.002367032 | 1 | 0 | GAD |
Lupus Erythematosus, Systemic | 0.002367032 | 1 | 0 | GAD |
Retinal Diseases | 0.001357209 | 5 | 2 | BeFree |
Vascular Diseases | 0.001357209 | 5 | 2 | BeFree |
Arteriosclerosis | 0.001085767 | 4 | 0 | BeFree |
Malignant neoplasm of breast | 0.000814326 | 3 | 0 | BeFree |
Restenosis | 0.000814326 | 3 | 0 | BeFree |
Breast Carcinoma | 0.000814326 | 3 | 0 | BeFree |
Ischemic stroke | 0.000814326 | 3 | 2 | BeFree |
Aortic Aneurysm | 0.000542884 | 2 | 0 | BeFree |
Crohn Disease | 0.000542884 | 2 | 0 | BeFree |
Hodgkin Disease | 0.000542884 | 2 | 2 | BeFree |
Huntington Disease | 0.000542884 | 2 | 2 | BeFree |
Multiple Sclerosis | 0.000542884 | 2 | 0 | BeFree |
Malignant neoplasm of mouth | 0.000542884 | 2 | 0 | BeFree |
Tumor Progression | 0.000542884 | 2 | 0 | BeFree |
Lip and Oral Cavity Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Carcinogenesis | 0.000542884 | 2 | 0 | BeFree |
Stomach Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Ischemic Cerebrovascular Accident | 0.000542884 | 2 | 2 | BeFree |
Autistic Disorder | 0.000271442 | 1 | 0 | BeFree |
Colonic Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Cystic Fibrosis | 0.000271442 | 1 | 0 | BeFree |
Presenile dementia | 0.000271442 | 1 | 0 | BeFree |
Ischemia | 0.000271442 | 1 | 0 | BeFree |
Transient ischemia | 0.000271442 | 1 | 0 | BeFree |
Myeloid Leukemia, Chronic | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of stomach | 0.000271442 | 1 | 0 | BeFree |
Myositis | 0.000271442 | 1 | 0 | BeFree |
Obesity | 0.000271442 | 1 | 0 | BeFree |
Pneumonia | 0.000271442 | 1 | 0 | BeFree |
Pulmonary Emphysema | 0.000271442 | 1 | 0 | BeFree |
Polycystic Kidney, Autosomal Dominant | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of testis | 0.000271442 | 1 | 0 | BeFree |
Reactive systemic amyloidosis | 0.000271442 | 1 | 0 | BeFree |
Inclusion Body Myositis (disorder) | 0.000271442 | 1 | 0 | BeFree |
Anaplastic thyroid carcinoma | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of lung | 0.000271442 | 1 | 0 | BeFree |
Chronic Periodontitis | 0.000271442 | 1 | 0 | BeFree |
Disseminated Malignant Neoplasm | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of prostate | 0.000271442 | 1 | 0 | BeFree |
Dementia | 0.000271442 | 1 | 0 | BeFree |
Prostate carcinoma | 0.000271442 | 1 | 0 | BeFree |
Epithelial ovarian cancer | 0.000271442 | 1 | 0 | BeFree |
Carcinoma of lung | 0.000271442 | 1 | 0 | BeFree |
Microalbuminuria | 0.000271442 | 1 | 2 | BeFree |
Endothelial dysfunction | 0.000271442 | 1 | 0 | BeFree |
Hepatocarcinogenesis | 0.000271442 | 1 | 0 | BeFree |
Colorectal Cancer | 0.000271442 | 1 | 2 | BeFree |
Malformations of Cortical Development | 0.000271442 | 1 | 0 | BeFree |
Liver carcinoma | 0.000271442 | 1 | 0 | BeFree |
Nasopharyngeal carcinoma | 0.000271442 | 1 | 0 | BeFree |
Plaque, Amyloid | 0.000271442 | 1 | 0 | BeFree |
AA amyloidosis | 0.000271442 | 1 | 0 | BeFree |
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