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The protein encoded by this gene is an adenosine receptor that belongs to the G-protein coupled receptor 1 family. There are 3 types of adenosine receptors, each with a specific pattern of ligand binding and tissue distribution, and together they regulate a diverse set of physiologic functions. The type A1 receptors inhibit adenylyl cyclase, and play a role in the fertilization process. Animal studies also suggest a role for A1 receptors in kidney function and ethanol intoxication. Transcript variants with alternative splicing in the 5' UTR have been found for this gene. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  由该基因编码的蛋白质是腺苷受体属于G-蛋白偶联受体1家族。有3种类型的腺苷受体,每种配体结合和组织分布的一个特定的图案,他们一起调节一组不同的生理功能。类型A1受体抑制腺苷酸环化酶,并发挥在受精过程中发挥作用。动物研究还表明A 1受体在肾功能和乙醇中毒的作用。用在5‘端非编码区剪接转录物变体已经发现这种基因。 [由RefSeq的,2008年7月提供]
ADORA1基因(以及对应的蛋白质)的细胞分布位置:
ADORA1基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Drug Allergy | 0.122367032 | 1 | 0 | CTD_human_GAD |
Myocardial Infarction | 0.122367032 | 2 | 0 | CTD_human_GAD |
Ischemia | 0.120271442 | 2 | 0 | BeFree_CTD_human |
Catalepsy | 0.12 | 1 | 0 | CTD_human |
Transient Ischemic Attack | 0.12 | 1 | 0 | CTD_human |
Hypotension | 0.12 | 2 | 0 | CTD_human |
Nerve Degeneration | 0.12 | 1 | 0 | CTD_human |
Prenatal Exposure Delayed Effects | 0.12 | 1 | 0 | CTD_human |
Subarachnoid Hemorrhage | 0.12 | 1 | 0 | CTD_human |
Substance Withdrawal Syndrome | 0.12 | 1 | 0 | CTD_human |
Adverse reaction to drug | 0.12 | 1 | 0 | CTD_human |
Ventricular Dysfunction | 0.12 | 1 | 0 | CTD_human |
Bradycardia | 0.12 | 1 | 0 | CTD_human |
Infarction, Middle Cerebral Artery | 0.12 | 1 | 0 | CTD_human |
Hypertensive disease | 0.084734064 | 3 | 0 | GAD_RGD |
Cerebral Infarction | 0.08 | 1 | 0 | RGD |
Diabetes Mellitus, Experimental | 0.08 | 2 | 0 | RGD |
Diabetic Nephropathy | 0.08 | 1 | 0 | RGD |
Hyperalgesia | 0.08 | 1 | 0 | RGD |
Inflammation | 0.08 | 1 | 0 | RGD |
Insulin Resistance | 0.08 | 1 | 0 | RGD |
Lung diseases | 0.08 | 1 | 0 | RGD |
Ventricular Fibrillation | 0.08 | 1 | 0 | RGD |
Ventricular Dysfunction, Left | 0.08 | 1 | 0 | RGD |
Sleep Apnea, Obstructive | 0.08 | 1 | 0 | RGD |
Asthma | 0.005819831 | 6 | 1 | BeFree_GAD |
Cardiomyopathy, Dilated | 0.00272435 | 1 | 0 | LHGDN |
Pick Disease of the Brain | 0.00272435 | 1 | 0 | LHGDN |
Anxiety Disorders | 0.002638474 | 2 | 1 | BeFree_GAD |
Bipolar Disorder | 0.002638474 | 1 | 0 | BeFree_GAD |
Schizophrenia | 0.002638474 | 1 | 0 | BeFree_GAD |
Myocardial Ischemia | 0.002638474 | 2 | 0 | BeFree_GAD |
Epilepsy, Post-Traumatic | 0.002367032 | 1 | 0 | GAD |
Fatigue | 0.002367032 | 1 | 0 | GAD |
Sleep Initiation and Maintenance Disorders | 0.002367032 | 1 | 0 | GAD |
Panic Disorder | 0.002367032 | 1 | 0 | GAD |
Seizures | 0.002367032 | 1 | 0 | GAD |
Sleep Disorders | 0.002367032 | 1 | 0 | GAD |
Cardiomyopathies | 0.002367032 | 1 | 0 | GAD |
Diabetes | 0.000814326 | 3 | 0 | BeFree |
Diabetes Mellitus | 0.000814326 | 3 | 0 | BeFree |
Diabetes Mellitus, Insulin-Dependent | 0.000542884 | 2 | 0 | BeFree |
Airway Obstruction | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of breast | 0.000271442 | 1 | 0 | BeFree |
Coronary Arteriosclerosis | 0.000271442 | 1 | 0 | BeFree |
Headache | 0.000271442 | 1 | 1 | BeFree |
Myeloid Leukemia, Chronic | 0.000271442 | 1 | 0 | BeFree |
Obesity | 0.000271442 | 1 | 0 | BeFree |
Severe Combined Immunodeficiency | 0.000271442 | 1 | 0 | BeFree |
Essential Hypertension | 0.000271442 | 1 | 0 | BeFree |
Breast Carcinoma | 0.000271442 | 1 | 0 | BeFree |
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