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The protein encoded by this gene is a preprohormone which is cleaved to form two biologically active peptides, adrenomedullin and proadrenomedullin N-terminal 20 peptide. Adrenomedullin is a 52 aa peptide with several functions, including vasodilation, regulation of hormone secretion, promotion of angiogenesis, and antimicrobial activity. The antimicrobial activity is antibacterial, as the peptide has been shown to kill E. coli and S. aureus at low concentration. [provided by RefSeq, Aug 2014]
[中文简述(自动翻译):]  由该基因编码的蛋白是被裂解以形成两个生物活性肽,肾上腺髓质素以及肾上腺髓质素N-末端20肽的前激素原。肾上腺髓质素是一种52个氨基酸肽与几个功能,包括血管扩张,激素分泌的调节,促进血管的,和抗菌活性。抗菌活性是抗菌,因为该肽已经显示杀灭大肠杆菌和金黄色葡萄球菌在低浓度。 [由RefSeq的,2014年8月提供]
ADM基因(以及对应的蛋白质)的细胞分布位置:
ADM基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Sepsis | 0.212797494 | 11 | 0 | BeFree_CTD_human_LHGDN_RGD |
Glomerulonephritis | 0.200271442 | 5 | 0 | BeFree_CTD_human_RGD |
Hyperalgesia | 0.2 | 1 | 0 | CTD_human_RGD |
Liver Cirrhosis, Experimental | 0.2 | 3 | 0 | CTD_human_RGD |
Autistic Disorder | 0.120271442 | 2 | 0 | BeFree_CTD_human |
Pain | 0.12 | 1 | 0 | CTD_human |
Gastric ulcer | 0.12 | 1 | 0 | CTD_human |
Hypertensive disease | 0.093711509 | 15 | 0 | BeFree_GAD_LHGDN_RGD |
Heart failure | 0.086263026 | 5 | 0 | BeFree_LHGDN_RGD |
Septic Shock | 0.0854487 | 4 | 0 | LHGDN_RGD |
Cerebrovascular accident | 0.083538676 | 4 | 0 | BeFree_LHGDN_RGD |
Ureteral obstruction | 0.082995792 | 2 | 0 | BeFree_LHGDN_RGD |
Cardiac Arrhythmia | 0.08272435 | 2 | 0 | LHGDN_RGD |
Reperfusion Injury | 0.08272435 | 2 | 0 | LHGDN_RGD |
Acidosis | 0.08 | 1 | 0 | RGD |
Hypertrophic Cardiomyopathy | 0.08 | 1 | 0 | RGD |
Diabetes Mellitus, Experimental | 0.08 | 1 | 0 | RGD |
Jaundice, Obstructive | 0.08 | 1 | 0 | RGD |
Shock, Hemorrhagic | 0.08 | 1 | 0 | RGD |
Starvation | 0.08 | 1 | 0 | RGD |
Hydrops Fetalis, Non-Immune | 0.08 | 0 | 0 | MGD |
Pre-Eclampsia | 0.010897401 | 4 | 0 | LHGDN |
Diabetes Mellitus, Non-Insulin-Dependent | 0.0089015 | 5 | 0 | BeFree_GAD_LHGDN |
Schizophrenia | 0.008358616 | 3 | 0 | BeFree_GAD_LHGDN |
Inflammation | 0.008173051 | 3 | 0 | LHGDN |
Pheochromocytoma | 0.007328931 | 27 | 0 | BeFree |
Cardiovascular Diseases | 0.005981653 | 13 | 0 | BeFree_LHGDN |
Prostatic Neoplasms | 0.005720142 | 2 | 0 | BeFree_LHGDN |
Cardiomegaly | 0.0054487 | 2 | 0 | LHGDN |
Ischemia | 0.004895885 | 8 | 0 | BeFree_LHGDN |
Blood pressure finding | 0.004734064 | 2 | 1 | GAD |
Systemic arterial pressure | 0.004734064 | 2 | 1 | GAD |
Liver carcinoma | 0.004624443 | 8 | 0 | BeFree_LHGDN |
Neoplasm Metastasis | 0.00408156 | 6 | 0 | BeFree_LHGDN |
Diabetic Nephropathy | 0.003538676 | 4 | 0 | BeFree_LHGDN |
Myocardial Infarction | 0.003538676 | 3 | 0 | BeFree_LHGDN |
Squamous cell carcinoma | 0.003267234 | 2 | 0 | BeFree_LHGDN |
Diabetic Angiopathies | 0.003267234 | 3 | 0 | BeFree_LHGDN |
IGA Glomerulonephritis | 0.003267234 | 2 | 0 | BeFree_LHGDN |
Mammary Neoplasms | 0.003267234 | 2 | 0 | BeFree_LHGDN |
Pulmonary Hypertension | 0.002995792 | 1 | 0 | BeFree_LHGDN |
Chronic Obstructive Airway Disease | 0.002995792 | 2 | 0 | BeFree_LHGDN |
Mucocutaneous Lymph Node Syndrome | 0.002995792 | 1 | 0 | BeFree_LHGDN |
HELLP Syndrome | 0.002995792 | 1 | 0 | BeFree_LHGDN |
Adrenal Cortical Adenoma | 0.002995792 | 2 | 0 | BeFree_LHGDN |
ovarian neoplasm | 0.002995792 | 2 | 0 | BeFree_LHGDN |
Cerebral Infarction | 0.002909916 | 3 | 0 | BeFree_GAD |
Anoxia | 0.00272435 | 1 | 0 | LHGDN |
Arterial Occlusive Diseases | 0.00272435 | 1 | 0 | LHGDN |
Chorioamnionitis | 0.00272435 | 1 | 0 | LHGDN |
Hypotension | 0.00272435 | 1 | 0 | LHGDN |
Pancreatic Neoplasm | 0.00272435 | 1 | 0 | LHGDN |
Proteinuria | 0.00272435 | 1 | 0 | LHGDN |
Pyelonephritis | 0.00272435 | 1 | 0 | LHGDN |
Sclerosis | 0.00272435 | 1 | 0 | LHGDN |
Uveitis | 0.00272435 | 1 | 0 | LHGDN |
Hyperparathyroidism, Primary | 0.00272435 | 1 | 0 | LHGDN |
Systemic Inflammatory Response Syndrome | 0.00272435 | 1 | 0 | LHGDN |
Stenosis | 0.00272435 | 1 | 0 | LHGDN |
Infection | 0.00272435 | 1 | 0 | LHGDN |
Kidney Diseases | 0.002714419 | 10 | 0 | BeFree |
Malignant neoplasm of breast | 0.002442977 | 9 | 0 | BeFree |
Breast Carcinoma | 0.002442977 | 9 | 0 | BeFree |
Bipolar Disorder | 0.002367032 | 1 | 1 | GAD |
Intracranial Arteriosclerosis | 0.002367032 | 1 | 0 | GAD |
Glucose Metabolism Disorders | 0.002367032 | 1 | 0 | GAD |
Prostate carcinoma | 0.002171535 | 8 | 0 | BeFree |
Diabetes | 0.001900093 | 7 | 0 | BeFree |
Diabetes Mellitus | 0.001900093 | 7 | 0 | BeFree |
Glioblastoma | 0.001900093 | 7 | 0 | BeFree |
Obesity | 0.001900093 | 7 | 0 | BeFree |
Septicemia | 0.001900093 | 7 | 0 | BeFree |
Rheumatoid Arthritis | 0.001628651 | 6 | 0 | BeFree |
Congestive heart failure | 0.001628651 | 6 | 0 | BeFree |
Malignant neoplasm of prostate | 0.001628651 | 6 | 0 | BeFree |
Arteriosclerosis | 0.001357209 | 5 | 0 | BeFree |
Ovarian Carcinoma | 0.001357209 | 5 | 0 | BeFree |
Vascular Diseases | 0.001357209 | 5 | 0 | BeFree |
Epithelial ovarian cancer | 0.001357209 | 5 | 0 | BeFree |
Atherosclerosis | 0.001085767 | 4 | 0 | BeFree |
Colorectal Carcinoma | 0.001085767 | 4 | 0 | BeFree |
Glioma | 0.001085767 | 4 | 0 | BeFree |
Essential Hypertension | 0.001085767 | 4 | 0 | BeFree |
Pancreatic carcinoma | 0.001085767 | 4 | 0 | BeFree |
Malignant neoplasm of lung | 0.001085767 | 4 | 0 | BeFree |
Malignant neoplasm of pancreas | 0.001085767 | 4 | 0 | BeFree |
Carcinogenesis | 0.001085767 | 4 | 0 | BeFree |
Carcinoma of lung | 0.001085767 | 4 | 0 | BeFree |
Colon Carcinoma | 0.001085767 | 4 | 0 | BeFree |
Malignant neoplasm of ovary | 0.001085767 | 4 | 0 | BeFree |
Colorectal Cancer | 0.001085767 | 4 | 0 | BeFree |
Malignant neoplasm of urinary bladder | 0.000814326 | 3 | 0 | BeFree |
Malignant tumor of colon | 0.000814326 | 3 | 0 | BeFree |
Choriocarcinoma | 0.000814326 | 3 | 0 | BeFree |
Diabetes Mellitus, Insulin-Dependent | 0.000814326 | 3 | 0 | BeFree |
Kidney Failure | 0.000814326 | 3 | 0 | BeFree |
Solid tumour | 0.000814326 | 3 | 0 | BeFree |
Carcinoma of bladder | 0.000814326 | 3 | 0 | BeFree |
Coronary Artery Disease | 0.000814326 | 3 | 0 | BeFree |
Adenocarcinoma | 0.000542884 | 2 | 0 | BeFree |
Astrocytoma | 0.000542884 | 2 | 0 | BeFree |
Colitis | 0.000542884 | 2 | 0 | BeFree |
Colorectal Neoplasms | 0.000542884 | 2 | 0 | BeFree |
Coronary Arteriosclerosis | 0.000542884 | 2 | 0 | BeFree |
Coronary heart disease | 0.000542884 | 2 | 0 | BeFree |
Dental caries | 0.000542884 | 2 | 0 | BeFree |
Eclampsia | 0.000542884 | 2 | 0 | BeFree |
Endometrial Hyperplasia | 0.000542884 | 2 | 0 | BeFree |
Heart Diseases | 0.000542884 | 2 | 0 | BeFree |
leukemia | 0.000542884 | 2 | 0 | BeFree |
Myeloid Leukemia | 0.000542884 | 2 | 0 | BeFree |
Liver neoplasms | 0.000542884 | 2 | 0 | BeFree |
Lung Neoplasms | 0.000542884 | 2 | 0 | BeFree |
Multiple Myeloma | 0.000542884 | 2 | 0 | BeFree |
Neuroblastoma | 0.000542884 | 2 | 0 | BeFree |
Degenerative polyarthritis | 0.000542884 | 2 | 0 | BeFree |
Osteosarcoma | 0.000542884 | 2 | 0 | BeFree |
Pituitary Diseases | 0.000542884 | 2 | 0 | BeFree |
Pregnancy, Tubal | 0.000542884 | 2 | 0 | BeFree |
Acute myocardial infarction | 0.000542884 | 2 | 0 | BeFree |
Glomerulosclerosis (disorder) | 0.000542884 | 2 | 0 | BeFree |
Adrenocortical carcinoma | 0.000542884 | 2 | 0 | BeFree |
Age related macular degeneration | 0.000542884 | 2 | 0 | BeFree |
Cervix carcinoma | 0.000542884 | 2 | 0 | BeFree |
Caries (morphologic abnormality) | 0.000542884 | 2 | 0 | BeFree |
Anaplastic astrocytoma | 0.000542884 | 2 | 0 | BeFree |
Endometrial Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Metabolic Syndrome X | 0.000542884 | 2 | 0 | BeFree |
Osteosarcoma of bone | 0.000542884 | 2 | 0 | BeFree |
Central neuroblastoma | 0.000542884 | 2 | 0 | BeFree |
Middle Cerebral Artery Occlusion | 0.000542884 | 2 | 0 | BeFree |
Cerebral Ischemia | 0.000542884 | 2 | 0 | BeFree |
Ischemic stroke | 0.000542884 | 2 | 0 | BeFree |
Invasive Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Tumor Angiogenesis | 0.000542884 | 2 | 0 | BeFree |
Ischemic Cerebrovascular Accident | 0.000542884 | 2 | 0 | BeFree |
Angina, Unstable | 0.000271442 | 1 | 0 | BeFree |
Asphyxia Neonatorum | 0.000271442 | 1 | 0 | BeFree |
Asthma | 0.000271442 | 1 | 0 | BeFree |
Autoimmune Diseases | 0.000271442 | 1 | 0 | BeFree |
Brain Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of endometrium | 0.000271442 | 1 | 0 | BeFree |
Cerebral Palsy | 0.000271442 | 1 | 0 | BeFree |
Malignant tumor of cervix | 0.000271442 | 1 | 0 | BeFree |
Colonic Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Connective Tissue Diseases | 0.000271442 | 1 | 0 | BeFree |
Diabetic Ketoacidosis | 0.000271442 | 1 | 0 | BeFree |
Encephalitis | 0.000271442 | 1 | 0 | BeFree |
Endometrial Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Angle Closure Glaucoma | 0.000271442 | 1 | 0 | BeFree |
Herpes Simplex Infections | 0.000271442 | 1 | 0 | BeFree |
Hyperglycemia | 0.000271442 | 1 | 0 | BeFree |
Hyperlipidemia | 0.000271442 | 1 | 0 | BeFree |
Malignant Hypertension | 0.000271442 | 1 | 0 | BeFree |
Hypertension, Renovascular | 0.000271442 | 1 | 0 | BeFree |
Ileitis | 0.000271442 | 1 | 0 | BeFree |
Immunologic Deficiency Syndromes | 0.000271442 | 1 | 0 | BeFree |
Transient ischemia | 0.000271442 | 1 | 0 | BeFree |
Kidney Failure, Chronic | 0.000271442 | 1 | 0 | BeFree |
Leukemia, Myelocytic, Acute | 0.000271442 | 1 | 0 | BeFree |
Lupus Erythematosus, Systemic | 0.000271442 | 1 | 0 | BeFree |
Lupus Nephritis | 0.000271442 | 1 | 0 | BeFree |
Muscle Rigidity | 0.000271442 | 1 | 0 | BeFree |
Myositis | 0.000271442 | 1 | 0 | BeFree |
Neurofibromatosis 1 | 0.000271442 | 1 | 0 | BeFree |
oligodendroglioma | 0.000271442 | 1 | 0 | BeFree |
Retinal Necrosis Syndrome, Acute | 0.000271442 | 1 | 0 | BeFree |
Seizures | 0.000271442 | 1 | 1 | BeFree |
Skin Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Stricture of artery | 0.000271442 | 1 | 0 | BeFree |
Urinary tract infection | 0.000271442 | 1 | 0 | BeFree |
Varicosity | 0.000271442 | 1 | 0 | BeFree |
Peripheral Vascular Diseases | 0.000271442 | 1 | 0 | BeFree |
Severe Combined Immunodeficiency | 0.000271442 | 1 | 0 | BeFree |
Acute leukemia | 0.000271442 | 1 | 0 | BeFree |
Pancreatitis, Chronic | 0.000271442 | 1 | 0 | BeFree |
Renal fibrosis | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of mouth | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of brain | 0.000271442 | 1 | 0 | BeFree |
Secondary malignant neoplasm of bone | 0.000271442 | 1 | 0 | BeFree |
Proliferative diabetic retinopathy | 0.000271442 | 1 | 0 | BeFree |
Corneal pannus | 0.000271442 | 1 | 0 | BeFree |
Swelling of limb | 0.000271442 | 1 | 0 | BeFree |
Tumor Progression | 0.000271442 | 1 | 0 | BeFree |
Lung Diseases, Interstitial | 0.000271442 | 1 | 0 | BeFree |
Teratocarcinoma | 0.000271442 | 1 | 0 | BeFree |
Lip and Oral Cavity Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Bipolar II disorder | 0.000271442 | 1 | 0 | BeFree |
Interstitial fibrosis | 0.000271442 | 1 | 0 | BeFree |
Proliferative vitreoretinopathy | 0.000271442 | 1 | 0 | BeFree |
Carcinoma, Lewis Lung | 0.000271442 | 1 | 0 | BeFree |
Chronic heart failure | 0.000271442 | 1 | 0 | BeFree |
Chronic cerebral ischemia | 0.000271442 | 1 | 0 | BeFree |
Chronic acquired lymphedema | 0.000271442 | 1 | 0 | BeFree |
Syndrome of infant of diabetic mother | 0.000271442 | 1 | 0 | BeFree |
Impaired glucose tolerance | 0.000271442 | 1 | 0 | BeFree |
Carcinoma breast stage IV | 0.000271442 | 1 | 0 | BeFree |
Bladder cancer recurrent | 0.000271442 | 1 | 0 | BeFree |
Adenocarcinoma of pancreas | 0.000271442 | 1 | 0 | BeFree |
Pilocytic Astrocytoma | 0.000271442 | 1 | 0 | BeFree |
Stable angina | 0.000271442 | 1 | 0 | BeFree |
Choroid Plexus Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Hepatitis C, Chronic | 0.000271442 | 1 | 0 | BeFree |
Fluid overload | 0.000271442 | 1 | 0 | BeFree |
Sentinel node (disorder) | 0.000271442 | 1 | 0 | BeFree |
Secondary malignant neoplasm of lymph node | 0.000271442 | 1 | 0 | BeFree |
Community acquired pneumonia | 0.000271442 | 1 | 0 | BeFree |
Macular fibrosis | 0.000271442 | 1 | 0 | BeFree |
Primary malignant neoplasm of brain | 0.000271442 | 1 | 0 | BeFree |
Well Differentiated Oligodendroglioma | 0.000271442 | 1 | 0 | BeFree |
Malignant Peripheral Nerve Sheath Tumor | 0.000271442 | 1 | 0 | BeFree |
Medullary Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Hypoxic-Ischemic Encephalopathy | 0.000271442 | 1 | 0 | BeFree |
Carcinogenicity | 0.000271442 | 1 | 0 | BeFree |
Precursor B-cell lymphoblastic leukemia | 0.000271442 | 1 | 0 | BeFree |
Cardiovascular morbidity | 0.000271442 | 1 | 0 | BeFree |
Peripheral vascular insufficiency | 0.000271442 | 1 | 0 | BeFree |
Cardiomyopathy, Familial Idiopathic | 0.000271442 | 1 | 0 | BeFree |
Angiogenic Switch | 0.000271442 | 1 | 0 | BeFree |
Neoplasms, Intracranial | 0.000271442 | 1 | 0 | BeFree |
Renal Insufficiency | 0.000271442 | 1 | 0 | BeFree |
Benign Prostatic Hyperplasia | 0.000271442 | 1 | 0 | BeFree |
Uterine Corpus Cancer | 0.000271442 | 1 | 0 | BeFree |
Dysglycemia | 0.000271442 | 1 | 0 | BeFree |
Chronic kidney disease stage 5 | 0.000271442 | 1 | 0 | BeFree |
Severe hypoxic ischemic encephalopathy | 0.000271442 | 1 | 0 | BeFree |
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