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This gene encodes a member of the EGF-TM7 subfamily of adhesion G protein-coupled receptors, which mediate cell-cell interactions. These proteins are cleaved by self-catalytic proteolysis into a large extracellular subunit and seven-span transmembrane subunit, which associate at the cell surface as a receptor complex. The encoded protein may play a role in cell adhesion as well as leukocyte recruitment, activation and migration, and contains multiple extracellular EGF-like repeats which mediate binding to chondroitin sulfate and the cell surface complement regulatory protein CD55. Expression of this gene may play a role in the progression of several types of cancer. Alternatively spliced transcript variants encoding multiple isoforms with 3 to 5 EGF-like repeats have been observed for this gene. This gene is found in a cluster with other EGF-TM7 genes on the short arm of chromosome 19. [provided by RefSeq, Jun 2011]
[中文简述(自动翻译):]  这个基因编码粘附G蛋白偶联受体,其介导细胞 - 细胞相互作用的EGF-TM7亚科的成员。这些蛋白质是由自我催化水解裂解成一个大的胞外亚基和七个跨跨膜亚基,其在细胞表面相关联作为受体复合物。所编码的蛋白质可在细胞粘附作用以及白细胞募集,活化和迁移,以及包含多个外EGF样重复其介导结合硫酸软骨素和细胞表面补体调节蛋白CD55。这个基因的表达可能在几种类型的癌症的进展的作用。可变剪接转录物变体具有3至5 EGF样重复已经观察到这种基因编码多种亚型。该基因与19号染色体短臂其他EGF-TM7基因簇被发现[由RefSeq的,2011年6月提供]
ADGRE5基因(以及对应的蛋白质)的细胞分布位置:
ADGRE5基因的本体(GO)信息:
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