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Adducins are a family of cytoskeleton proteins encoded by three genes (alpha, beta, gamma). Adducin is a heterodimeric protein that consists of related subunits, which are produced from distinct genes but share a similar structure. Alpha- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Alpha- and gamma-adducins are ubiquitously expressed. In contrast, beta-adducin is expressed at high levels in brain and hematopoietic tissues. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C. Alternative splicing results in multiple variants encoding distinct isoforms; however, not all variants have been fully described. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  Adducins是由三个基因(α,β,γ)编码细胞骨架蛋白家族。收蛋白是由相关的亚基,它是由不同的基因产生,但有着相似的结构的异二聚体蛋白质。 α-和β-内收蛋白包括一个蛋白酶抗性N末端区域和一个蛋白酶敏感的,亲水性的C-末端区域。甲型和γ-adducins被普遍表达。与此相反,β-内收蛋白以高水平在大脑和造血组织中表达。收蛋白结合以高亲和力的Ca(2 +)/钙调蛋白和是用于编码不同的同种型的多个变体的蛋白激酶A和C选择性剪接的结果的基板;然而,并非所有的变体已被充分地描述。 [由RefSeq的,2008年7月提供]
ADD1基因(以及对应的蛋白质)的细胞分布位置:
ADD1基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Hypertensive disease | 0.320805665 | 90 | 4 | BeFree_CTD_human_GAD_LHGDN_RGD |
Essential Hypertension | 0.130043349 | 37 | 1 | BeFree_CTD_human |
Liver carcinoma | 0.12 | 1 | 0 | CTD_human |
Epilepsy, Temporal Lobe | 0.08 | 1 | 0 | RGD |
Systemic arterial pressure | 0.02367032 | 10 | 0 | GAD |
Myocardial Infarction | 0.016816922 | 9 | 2 | BeFree_GAD_LHGDN |
Cerebrovascular accident | 0.016731045 | 9 | 3 | BeFree_GAD_LHGDN |
Cardiovascular Diseases | 0.013278246 | 6 | 1 | BeFree_GAD_LHGDN |
Coronary Artery Disease | 0.012821238 | 3 | 1 | BeFree_GAD_LHGDN |
Diabetes Mellitus, Non-Insulin-Dependent | 0.01246392 | 5 | 0 | BeFree_GAD_LHGDN |
Cerebral Palsy | 0.007372538 | 4 | 0 | BeFree_GAD |
Blood pressure finding | 0.007101096 | 3 | 0 | GAD |
Coronary heart disease | 0.006362715 | 8 | 1 | BeFree_GAD |
Kidney Failure, Chronic | 0.00554839 | 4 | 1 | BeFree_GAD |
Endolymphatic Hydrops | 0.005362824 | 1 | 1 | BeFree_GAD_LHGDN |
Albuminuria | 0.005091382 | 2 | 0 | GAD_LHGDN |
Meniere Disease | 0.005091382 | 1 | 0 | GAD_LHGDN |
Meningococcal Infections | 0.005091382 | 1 | 0 | GAD_LHGDN |
Hypercholesterolemia, Familial | 0.004734064 | 2 | 0 | GAD |
Kidney Diseases | 0.003181358 | 4 | 0 | BeFree_GAD |
Kidney Failure | 0.003181358 | 4 | 1 | BeFree_GAD |
IGA Glomerulonephritis | 0.002909916 | 3 | 1 | BeFree_GAD |
Hyperaldosteronism | 0.00272435 | 1 | 0 | LHGDN |
Disease Progression | 0.00272435 | 1 | 0 | LHGDN |
Hyperlipidemia, Familial Combined | 0.002638474 | 1 | 1 | BeFree_GAD |
Gastroschisis | 0.002638474 | 1 | 3 | BeFree_GAD |
Alcoholic Intoxication, Chronic | 0.002367032 | 1 | 0 | GAD |
Amyotrophic Lateral Sclerosis | 0.002367032 | 1 | 0 | GAD |
Carotid Artery Diseases | 0.002367032 | 1 | 0 | GAD |
Brain Ischemia | 0.002367032 | 1 | 0 | GAD |
Cerebrovascular Disorders | 0.002367032 | 1 | 0 | GAD |
Polycystic Kidney Diseases | 0.002367032 | 1 | 0 | GAD |
Pre-Eclampsia | 0.002367032 | 1 | 0 | GAD |
Vascular Diseases | 0.002367032 | 1 | 0 | GAD |
Peripheral Vascular Diseases | 0.002367032 | 1 | 0 | GAD |
Premature Birth | 0.002367032 | 1 | 0 | GAD |
Myocardial Ischemia | 0.002367032 | 1 | 0 | GAD |
Restenosis | 0.002367032 | 1 | 0 | GAD |
Cardiac Death | 0.002367032 | 1 | 0 | GAD |
Left ventricular mass | 0.002367032 | 1 | 0 | GAD |
Brain hemorrhage | 0.002367032 | 1 | 0 | GAD |
Pregnancy associated hypertension | 0.002367032 | 1 | 0 | GAD |
Acute Coronary Syndrome | 0.002367032 | 1 | 0 | GAD |
Creatinine finding | 0.002367032 | 1 | 0 | GAD |
Venous Thromboembolism | 0.002367032 | 1 | 0 | GAD |
Cerebral Hemorrhage | 0.002367032 | 1 | 0 | GAD |
Hypotension Adverse Event | 0.002367032 | 1 | 0 | GAD |
Arteriosclerosis | 0.000814326 | 3 | 1 | BeFree |
Atherosclerosis | 0.000814326 | 3 | 1 | BeFree |
Congenital chromosomal disease | 0.000814326 | 3 | 0 | BeFree |
Coronary Arteriosclerosis | 0.000814326 | 3 | 1 | BeFree |
Leukemia, Myelocytic, Acute | 0.000814326 | 3 | 0 | BeFree |
Hodgkin Disease | 0.000542884 | 2 | 0 | BeFree |
Huntington Disease | 0.000542884 | 2 | 0 | BeFree |
Monosomy | 0.000542884 | 2 | 0 | BeFree |
Polycystic Kidney, Autosomal Dominant | 0.000542884 | 2 | 1 | BeFree |
Ischemic stroke | 0.000542884 | 2 | 0 | BeFree |
Chronic kidney disease stage 5 | 0.000542884 | 2 | 1 | BeFree |
Diabetes | 0.000271442 | 1 | 0 | BeFree |
Diabetes Mellitus | 0.000271442 | 1 | 0 | BeFree |
Diabetes Mellitus, Insulin-Dependent | 0.000271442 | 1 | 0 | BeFree |
Diabetic Nephropathy | 0.000271442 | 1 | 0 | BeFree |
Heart failure | 0.000271442 | 1 | 0 | BeFree |
Congestive heart failure | 0.000271442 | 1 | 0 | BeFree |
Hypernatremia | 0.000271442 | 1 | 1 | BeFree |
Renal hypertension | 0.000271442 | 1 | 1 | BeFree |
Obesity | 0.000271442 | 1 | 0 | BeFree |
Left Ventricular Hypertrophy | 0.000271442 | 1 | 0 | BeFree |
Secondary malignant neoplasm of lung | 0.000271442 | 1 | 0 | BeFree |
Chondromatosis | 0.000271442 | 1 | 0 | BeFree |
Endocrine hypertension | 0.000271442 | 1 | 0 | BeFree |
Xerocytosis | 0.000271442 | 1 | 0 | BeFree |
Monosomy 22 | 0.000271442 | 1 | 0 | BeFree |
Chondroma | 0.000271442 | 1 | 0 | BeFree |
Conn Syndrome | 0.000271442 | 1 | 0 | BeFree |
Peripheral Arterial Diseases | 0.000271442 | 1 | 0 | BeFree |
Ischemic Cerebrovascular Accident | 0.000271442 | 1 | 0 | BeFree |
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