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This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene has high sequence similarity to the protein encoded by ADAMTS18, another family member. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  该基因编码的ADAMTS的成员(去整合素和金属蛋白酶与血小板反应基序)的蛋白质家族。 ADAMTS家族成员共享几个不同的蛋白质模块,包括一个前肽区,金属蛋白酶结构域,一个去整合素样结构域,和一个血小板1型(TS)的基序。这个家庭的各个成员在C端TS图案的数量不同,有的有独特的C端结构域。由该基因编码的蛋白质具有高序列相似性由ADAMTS18,另一家族成员编码的蛋白质。 [由RefSeq的,2008年7月提供]
ADAMTS16基因(以及对应的蛋白质)的细胞分布位置:
ADAMTS16基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Amyotrophic Lateral Sclerosis | 0.002367032 | 1 | 1 | GAD |
Parkinson Disease | 0.002367032 | 1 | 1 | GAD |
Tobacco Use Disorder | 0.002367032 | 1 | 0 | GAD |
Chondrosarcoma | 0.000271442 | 1 | 0 | BeFree |
Esophageal Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Hypertensive disease | 0.000271442 | 1 | 0 | BeFree |
Premature Menopause | 0.000271442 | 1 | 0 | BeFree |
Degenerative polyarthritis | 0.000271442 | 1 | 0 | BeFree |
Ovarian Failure, Premature | 0.000271442 | 1 | 0 | BeFree |
Esophageal carcinoma | 0.000271442 | 1 | 0 | BeFree |
Squamous cell carcinoma of esophagus | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of esophagus | 0.000271442 | 1 | 0 | BeFree |
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