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This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. Unlike other members of the ADAM protein family, the protein encoded by this gene lacks metalloprotease activity since it has no zinc-binding motif. This gene is highly expressed in the brain and may function as an integrin ligand in the brain. In mice, it has been shown to be essential for correct myelination in the peripheral nervous system. Alternative splicing results in several transcript variants.[provided by RefSeq, Dec 2010]
[中文简述(自动翻译):]  该基因编码的ADAM(解联蛋白和金属蛋白酶结构域)家族的一个成员。该家族的成员在结构上相关的蛇毒解联膜 - 锚定蛋白,并且在多种涉及细胞 - 细胞和细胞 - 基质相互作用,包括受精,肌肉发育和神经发生的生物过程中有牵连。不像ADAM蛋白质家族的其它成员,由该基因编码的蛋白质缺乏金属蛋白酶活性,因为它没有锌结合基序。该基因是在大脑中高度表达,并且可以在大脑中的整联蛋白配起作用。在小鼠中,已经证明是在周围神经系统正确髓鞘必不可少的。选择性剪接结果在几个转录变异体。[由RefSeq的,2010年12月提供]
ADAM22基因(以及对应的蛋白质)的细胞分布位置:
ADAM22基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Epilepsy | 0.002995792 | 1 | 0 | BeFree_LHGDN |
| Schizophrenia | 0.002367032 | 1 | 0 | GAD |
| Tobacco Use Disorder | 0.002367032 | 1 | 0 | GAD |
| Glioma | 0.000542884 | 2 | 0 | BeFree |
| Malignant neoplasm of breast | 0.000271442 | 1 | 0 | BeFree |
| Seizures | 0.000271442 | 1 | 1 | BeFree |
| Breast Carcinoma | 0.000271442 | 1 | 0 | BeFree |
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