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This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This member is a type I transmembrane protein and serves as a marker for dendritic cell differentiation. It has been demonstrated to be an active metalloproteinase, which may be involved in normal physiological processes such as cell migration, cell adhesion, cell-cell and cell-matrix interactions, and signal transduction. It is proposed to play a role in pathological processes, such as cancer, inflammatory diseases, renal diseases, and Alzheimer's disease. [provided by RefSeq, May 2013]
[中文简述(自动翻译):]  该基??因编码的ADAM(解联蛋白和金属蛋白酶结构域)家族的一个成员。该家族的成员在结构上相关的蛇毒解联,并在各种涉及细胞 - 细胞和细胞 - 基质相互作用,包括受精,肌肉发育和神经发生的生物过程中有牵连的膜 - 锚定蛋白。此构件是I型跨膜蛋白,并作为树突状细胞的分化的标记物。它已被证明是一种活性金属蛋白酶,其可参与正常生理过程,如细胞迁移,细胞粘附,细胞 - 细胞和细胞 - 基质相互作用和信号转导。因此建议在病理过程,如癌症,炎性疾病,肾脏疾病,和阿尔茨海默氏病中发挥作用。 [由RefSeq的,2013年5月提供]
ADAM19基因(以及对应的蛋白质)的细胞分布位置:
ADAM19基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Pulmonary function (finding) | 0.122367032 | 2 | 1 | GAD_GWASCAT |
| ovarian neoplasm | 0.00272435 | 1 | 0 | LHGDN |
| Mental disorders | 0.002367032 | 1 | 1 | GAD |
| Lung diseases | 0.002367032 | 1 | 0 | GAD |
| Kidney Diseases | 0.000542884 | 2 | 0 | BeFree |
| Ovarian Carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Interstitial fibrosis | 0.000542884 | 2 | 0 | BeFree |
| Malignant neoplasm of ovary | 0.000542884 | 2 | 0 | BeFree |
| Colorectal Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Dermatomyositis | 0.000271442 | 1 | 0 | BeFree |
| Glioma | 0.000271442 | 1 | 0 | BeFree |
| Chronic Obstructive Airway Disease | 0.000271442 | 1 | 0 | BeFree |
| Lymphoma | 0.000271442 | 1 | 0 | BeFree |
| Polymyositis | 0.000271442 | 1 | 0 | BeFree |
| Adult type dermatomyositis | 0.000271442 | 1 | 0 | BeFree |
| Inclusion Body Myositis (disorder) | 0.000271442 | 1 | 0 | BeFree |
| Chronic rejection of renal transplant | 0.000271442 | 1 | 0 | BeFree |
| Brain Tumor, Primary | 0.000271442 | 1 | 0 | BeFree |
| Colorectal Cancer | 0.000271442 | 1 | 0 | BeFree |
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