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The protein encoded by this gene is a member of the ADAM (a disintegrin and metalloproteinase) protein family. ADAM family members are type I transmembrane glycoproteins known to be involved in cell adhesion and proteolytic ectodomain processing of cytokines and adhesion molecules. This protein contains multiple functional domains including a zinc-binding metalloprotease domain, a disintegrin-like domain, as well as a EGF-like domain. Through its disintegrin-like domain, this protein specifically interacts with the integrin beta chain, beta 3. It also interacts with Src family protein-tyrosine kinases in a phosphorylation-dependent manner, suggesting that this protein may function in cell-cell adhesion as well as in cellular signaling. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  由该基因编码的蛋白质是ADAM(解联和金属蛋白酶)的蛋白质家族的一个成员。 ADAM家族成员是I型跨膜已知参与细胞粘附和细胞因子和粘附分子的蛋白水解胞外域的处理的糖蛋白。此蛋白含有多个功能性结构域包括锌结合金属蛋白酶结构域,一个去整合素样结构域,以及一个EGF样结构域。通过其去整合素样结构域,该蛋白特异性地与整联β链相互作用,β3它还与一个磷酸化依赖性Src家族蛋白 - 酪氨酸激酶相互作用,这表明该蛋白可能在细胞 - 细胞粘连的作用,以及如在细胞信号。编码不同同种型的多个可变剪接转录物变体已观察到。 [由RefSeq的,2008年7月提供]
ADAM15基因(以及对应的蛋白质)的细胞分布位置:
ADAM15基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| melanoma | 0.003810118 | 4 | 0 | BeFree_LHGDN |
| Adenocarcinoma | 0.002995792 | 2 | 0 | BeFree_LHGDN |
| Inflammatory Bowel Diseases | 0.002995792 | 2 | 0 | BeFree_LHGDN |
| Prostatic Neoplasms | 0.002995792 | 1 | 0 | BeFree_LHGDN |
| Atrial Fibrillation | 0.00272435 | 1 | 0 | LHGDN |
| Pathologic Neovascularization | 0.00272435 | 1 | 0 | LHGDN |
| ovarian neoplasm | 0.00272435 | 1 | 0 | LHGDN |
| Mammary Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
| Schizophrenia | 0.002367032 | 1 | 0 | GAD |
| Rheumatoid Arthritis | 0.001085767 | 4 | 0 | BeFree |
| Malignant neoplasm of breast | 0.001085767 | 4 | 0 | BeFree |
| Neoplasm Metastasis | 0.001085767 | 4 | 0 | BeFree |
| Degenerative polyarthritis | 0.001085767 | 4 | 0 | BeFree |
| Arteriosclerosis | 0.000814326 | 3 | 0 | BeFree |
| Atherosclerosis | 0.000814326 | 3 | 0 | BeFree |
| Breast Carcinoma | 0.000814326 | 3 | 0 | BeFree |
| Tumor Progression | 0.000542884 | 2 | 0 | BeFree |
| Malignant neoplasm of prostate | 0.000542884 | 2 | 0 | BeFree |
| Prostate carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Anaplasia | 0.000271442 | 1 | 0 | BeFree |
| Squamous cell carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Chondrosarcoma | 0.000271442 | 1 | 0 | BeFree |
| Colorectal Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| External exotoses | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of stomach | 0.000271442 | 1 | 0 | BeFree |
| Cardiac dilatation | 0.000271442 | 1 | 0 | BeFree |
| inflammatory joint disease | 0.000271442 | 1 | 0 | BeFree |
| Carcinoma of lung | 0.000271442 | 1 | 0 | BeFree |
| Colon Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Stomach Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Malignant Squamous Cell Neoplasm | 0.000271442 | 1 | 0 | BeFree |
| Metastatic Prostate Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Arthritis, Collagen-Induced | 0.000271442 | 1 | 0 | BeFree |
| Mammary Carcinoma, Human | 0.000271442 | 1 | 0 | BeFree |
| Epithelioma | 0.000271442 | 1 | 0 | BeFree |
| Invasive Skin Melanoma | 0.000271442 | 1 | 0 | BeFree |
| Osteophyte | 0.000271442 | 1 | 0 | BeFree |
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