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This gene encodes a member of the ADAM (a disintegrin and metalloprotease) protein family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This gene represents a candidate tumor suppressor gene for human breast cancer based on its location within a minimal region of chromosome 17q21 previously defined by tumor deletion mapping. [provided by RefSeq, Dec 2014]
[中文简述(自动翻译):]  该基因编码的ADAM(解联蛋白和金属蛋白酶)的蛋白质家族的一个成员。该家族的成员在结构上相关的蛇毒解联膜 - 锚定蛋白,并且在多种涉及细胞 - 细胞和细胞 - 基质相互作用,包括受精,肌肉发育和神经发生的生物过程中有牵连。该基因表示根据它的位置之前由肿瘤缺失映射定义染色体17q21的微小区域内的人类乳腺癌的候选肿瘤抑制基因。 [由RefSeq的,2014年12月提供]
ADAM11基因(以及对应的蛋白质)的细胞分布位置:
ADAM11基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Alcoholic Intoxication, Chronic | 0.002367032 | 1 | 0 | GAD |
| Cerebrovascular accident | 0.000814326 | 3 | 2 | BeFree |
| Malignant neoplasm of breast | 0.000542884 | 2 | 0 | BeFree |
| HIV Infections | 0.000542884 | 2 | 0 | BeFree |
| Hodgkin Disease | 0.000542884 | 2 | 0 | BeFree |
| Hypertensive disease | 0.000542884 | 2 | 0 | BeFree |
| Breast Carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Arthritis, Psoriatic | 0.000271442 | 1 | 0 | BeFree |
| Coronary heart disease | 0.000271442 | 1 | 0 | BeFree |
| Exanthema | 0.000271442 | 1 | 0 | BeFree |
| Glioma | 0.000271442 | 1 | 0 | BeFree |
| Leukemia, T-Cell | 0.000271442 | 1 | 0 | BeFree |
| Adult T-Cell Lymphoma/Leukemia | 0.000271442 | 1 | 0 | BeFree |
| Myocardial Infarction | 0.000271442 | 1 | 0 | BeFree |
| Degenerative polyarthritis | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of lung | 0.000271442 | 1 | 0 | BeFree |
| Breast cancer recurrent | 0.000271442 | 1 | 0 | BeFree |
| Carcinoma of lung | 0.000271442 | 1 | 0 | BeFree |
| Ischemic stroke | 0.000271442 | 1 | 2 | BeFree |
| Ischemic Cerebrovascular Accident | 0.000271442 | 1 | 2 | BeFree |
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