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The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in uterus and spleen, and in trace amounts in normal brain, but has markedly increased levels in malignant gliomas. This gene functions in mediating fatty acid-induced glioma cell growth. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  由该基因编码的蛋白质是长链脂肪酸辅酶A连接酶家族的同工酶。虽然在底物特异性,亚细胞定位和组织分布不同,该家族的所有同工酶转换自由长链脂肪酸进入脂肪酰基辅酶A酯,从而起到脂质生物合成和脂肪酸降解的关键作用。此同功酶在子宫和脾脏高度表达,而在微量正常脑,但在恶性神经胶质瘤显着增强的水平。在介导脂肪酸诱导的神经胶质瘤细胞的生长这个基因的功能。已发现该基因编码的两种不同亚型三个抄本变形。 [由RefSeq的,2008年7月提供]
ACSL5基因(以及对应的蛋白质)的细胞分布位置:
ACSL5基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Arthritis, Experimental | 0.12 | 1 | 0 | CTD_human |
| Glioma | 0.003267234 | 2 | 0 | BeFree_LHGDN |
| Hyperlipidemia | 0.00272435 | 1 | 0 | LHGDN |
| Metaplasia | 0.00272435 | 1 | 0 | LHGDN |
| Tobacco Use Disorder | 0.002367032 | 1 | 0 | GAD |
| Weight Loss Adverse Event | 0.002367032 | 1 | 0 | GAD |
| Adenocarcinoma | 0.001085767 | 4 | 0 | BeFree |
| Adenoma | 0.000542884 | 2 | 0 | BeFree |
| Anaplasia | 0.000271442 | 1 | 0 | BeFree |
| Colorectal Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Lupus Erythematosus, Systemic | 0.000271442 | 1 | 0 | BeFree |
| Malignant Glioma | 0.000271442 | 1 | 0 | BeFree |
| Carcinogenesis | 0.000271442 | 1 | 0 | BeFree |
| Adenocarcinoma of large intestine | 0.000271442 | 1 | 0 | BeFree |
| Epithelioma | 0.000271442 | 1 | 0 | BeFree |
| Colorectal Cancer | 0.000271442 | 1 | 0 | BeFree |
| Adenocarcinoma, Endometrioid | 0.000271442 | 1 | 0 | BeFree |
| Postmenopausal endometrium | 0.000271442 | 1 | 0 | BeFree |
| Nonalcoholic Steatohepatitis | 0.000271442 | 1 | 0 | BeFree |
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