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Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  乙酰-CoA羧化酶(ACC)是一个复杂的多功能酶系统。 ACC是含生物素的酶,其催化乙酰-CoA到丙二酰-CoA,在脂肪酸合成的限速步骤的羧化。有两种ACC形式,α和β,由两个不同的基因编码。 ACC-α被高度富集脂肪生成的组织。酶是在转录和翻译水平下通过靶向丝氨酸残基的磷酸化/去磷酸化短期调节和由柠檬酸盐或棕榈酰辅酶A变构变换长期控制之下。多个可变剪接转录物变体的5‘序列和编码不同同种型发散已经发现这种基因。 [由RefSeq的,2008年7月提供]
ACACA基因(以及对应的蛋白质)的细胞分布位置:
ACACA基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Liver carcinoma | 0.120271442 | 2 | 2 | BeFree_CTD_human |
Celiac Disease | 0.12 | 1 | 1 | GWASCAT |
Fatty Liver | 0.08 | 1 | 0 | RGD |
Insulin Resistance | 0.08 | 1 | 0 | RGD |
Mammary Neoplasms | 0.010897401 | 4 | 0 | LHGDN |
Malignant neoplasm of breast | 0.006362715 | 6 | 0 | BeFree_GAD |
Hypercholesterolemia | 0.002638474 | 2 | 3 | BeFree_GAD |
Hyperlipidemia | 0.002638474 | 2 | 3 | BeFree_GAD |
Hypertriglyceridemia | 0.002367032 | 1 | 0 | GAD |
Tobacco Use Disorder | 0.002367032 | 1 | 0 | GAD |
Hypertriglyceridemia result | 0.002367032 | 1 | 0 | GAD |
Breast Carcinoma | 0.001628651 | 6 | 0 | BeFree |
Neoplasm Metastasis | 0.001357209 | 5 | 0 | BeFree |
Agenesis of corpus callosum | 0.001357209 | 5 | 0 | BeFree |
Carcinogenesis | 0.001357209 | 5 | 0 | BeFree |
Adenoid Cystic Carcinoma | 0.001085767 | 4 | 0 | BeFree |
Hereditary Motor and Sensory Neuropathies | 0.001085767 | 4 | 0 | BeFree |
Adenoma | 0.000814326 | 3 | 0 | BeFree |
Schizophrenia | 0.000814326 | 3 | 0 | BeFree |
Malignant Pleural Mesothelioma | 0.000814326 | 3 | 0 | BeFree |
Chronic graft-versus-host disease | 0.000814326 | 3 | 0 | BeFree |
Malignant tumor of colon | 0.000542884 | 2 | 0 | BeFree |
Diabetes Mellitus, Non-Insulin-Dependent | 0.000542884 | 2 | 0 | BeFree |
Graft-vs-Host Disease | 0.000542884 | 2 | 0 | BeFree |
Kidney Failure, Chronic | 0.000542884 | 2 | 0 | BeFree |
Myeloid Leukemia, Chronic | 0.000542884 | 2 | 0 | BeFree |
Lupus Erythematosus, Systemic | 0.000542884 | 2 | 0 | BeFree |
Mesothelioma | 0.000542884 | 2 | 0 | BeFree |
Obesity | 0.000542884 | 2 | 0 | BeFree |
Tuberculosis | 0.000542884 | 2 | 0 | BeFree |
Adrenocortical carcinoma | 0.000542884 | 2 | 0 | BeFree |
Chronic Periodontitis | 0.000542884 | 2 | 0 | BeFree |
Malignant mesothelioma | 0.000542884 | 2 | 0 | BeFree |
Malignant neoplasm of prostate | 0.000542884 | 2 | 0 | BeFree |
Prostate carcinoma | 0.000542884 | 2 | 0 | BeFree |
Colon Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Corpus callosum agenesis neuronopathy | 0.000542884 | 2 | 0 | BeFree |
Acute GVH disease | 0.000542884 | 2 | 0 | BeFree |
Tumors of Adrenal Cortex | 0.000271442 | 1 | 0 | BeFree |
Autistic Disorder | 0.000271442 | 1 | 0 | BeFree |
Cachexia | 0.000271442 | 1 | 1 | BeFree |
Malignant neoplasm of larynx | 0.000271442 | 1 | 0 | BeFree |
Squamous cell carcinoma | 0.000271442 | 1 | 0 | BeFree |
Ulcerative Colitis | 0.000271442 | 1 | 0 | BeFree |
Endometriosis | 0.000271442 | 1 | 0 | BeFree |
Exanthema | 0.000271442 | 1 | 0 | BeFree |
Gastritis | 0.000271442 | 1 | 0 | BeFree |
Gingivitis | 0.000271442 | 1 | 0 | BeFree |
Hepatitis B | 0.000271442 | 1 | 0 | BeFree |
Hyperinsulinism | 0.000271442 | 1 | 0 | BeFree |
Hypertrichosis | 0.000271442 | 1 | 2 | BeFree |
Inflammatory Bowel Diseases | 0.000271442 | 1 | 0 | BeFree |
leukemia | 0.000271442 | 1 | 0 | BeFree |
Leukemia, Lymphocytic, Acute, L1 | 0.000271442 | 1 | 0 | BeFree |
Ovarian Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Pain | 0.000271442 | 1 | 0 | BeFree |
Pemphigus Vulgaris | 0.000271442 | 1 | 0 | BeFree |
Psoriasis | 0.000271442 | 1 | 0 | BeFree |
Kidney Failure | 0.000271442 | 1 | 0 | BeFree |
Respiratory Distress Syndrome, Adult | 0.000271442 | 1 | 0 | BeFree |
Small cell carcinoma of lung | 0.000271442 | 1 | 0 | BeFree |
Acute myocardial infarction | 0.000271442 | 1 | 0 | BeFree |
Adrenal Cortical Adenoma | 0.000271442 | 1 | 0 | BeFree |
Follicular thyroid carcinoma | 0.000271442 | 1 | 0 | BeFree |
Invasive Pulmonary Aspergillosis | 0.000271442 | 1 | 0 | BeFree |
Squamous cell carcinoma of esophagus | 0.000271442 | 1 | 0 | BeFree |
Mixed Oligodendroglioma-Astrocytoma | 0.000271442 | 1 | 0 | BeFree |
Chronic active hepatitis | 0.000271442 | 1 | 2 | BeFree |
Beta thalassemia trait | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of ovary | 0.000271442 | 1 | 0 | BeFree |
Sarcoma | 0.000271442 | 1 | 0 | BeFree |
Atypical teratoid/rhabdoid tumor | 0.000271442 | 1 | 0 | BeFree |
Lattice corneal dystrophy Type I | 0.000271442 | 1 | 0 | BeFree |
Coronary Artery Disease | 0.000271442 | 1 | 0 | BeFree |
aggressive cancer | 0.000271442 | 1 | 0 | BeFree |
Juvenile arthritis | 0.000271442 | 1 | 0 | BeFree |
Juvenile rheumatoid arthritis | 0.000271442 | 1 | 0 | BeFree |
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