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The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This ABC full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. The product of this gene participates in physiological processes involving bile acids, conjugated steroids, and cyclic nucleotides. In addition, a SNP in this gene is responsible for determination of human earwax type. This gene and family member ABCC12 are determined to be derived by duplication and are both localized to chromosome 16q12.1. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  该基因编码的蛋白是ATP结合盒(ABC)转运超家族中的一员。 ABC蛋白质跨越预算外内和细胞膜输送各种分子。 ABC基因被分为七个不同亚科(ABC1,MDR / TAP,MRP,ALD,OABP,GCN20,白色)。此ABC充分转运是其参与多药耐药性的MRP亚科的成员。该基因的产物参与涉及胆汁酸,共轭类固醇,和环核苷酸的生理过程。此外,在该基因的SNP是负责测定人耳垢类型。这个基因和家族成员ABCC12决心通过重复得到,并均定位于染色体16q12.1。多个可变剪接转录物变体已被用于这个基因说明。 [由RefSeq的,2008年7月提供]
ABCC11基因(以及对应的蛋白质)的细胞分布位置:
ABCC11基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Disease Progression | 0.12 | 1 | 0 | CTD_human |
EAR WAX, WET/DRY | 0.12 | 0 | 1 | CLINVAR |
Malignant neoplasm of breast | 0.004810009 | 9 | 0 | BeFree_GAD |
Vasculitis | 0.002995792 | 2 | 0 | BeFree_LHGDN |
Breast Carcinoma | 0.002442977 | 9 | 0 | BeFree |
Sweat Gland Diseases | 0.002367032 | 1 | 0 | GAD |
Acute Promyelocytic Leukemia | 0.001085767 | 4 | 0 | BeFree |
Bromhidrosis | 0.001085767 | 4 | 0 | BeFree |
Septicemia | 0.000814326 | 3 | 0 | BeFree |
Sepsis | 0.000814326 | 3 | 0 | BeFree |
Cystic Fibrosis | 0.000542884 | 2 | 0 | BeFree |
leukemia | 0.000542884 | 2 | 0 | BeFree |
Leukemia, Myelocytic, Acute | 0.000542884 | 2 | 0 | BeFree |
Carcinogenesis | 0.000542884 | 2 | 0 | BeFree |
Abdominal sepsis | 0.000542884 | 2 | 0 | BeFree |
Mammary Neoplasms | 0.000542884 | 2 | 0 | BeFree |
Rheumatoid Arthritis | 0.000271442 | 1 | 0 | BeFree |
Female Breast Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Corneal Diseases | 0.000271442 | 1 | 0 | BeFree |
Diabetes | 0.000271442 | 1 | 0 | BeFree |
Diabetes Mellitus | 0.000271442 | 1 | 0 | BeFree |
Diabetes Mellitus, Insulin-Dependent | 0.000271442 | 1 | 0 | BeFree |
Diabetes Mellitus, Non-Insulin-Dependent | 0.000271442 | 1 | 0 | BeFree |
Diabetic Nephropathy | 0.000271442 | 1 | 0 | BeFree |
Keratitis | 0.000271442 | 1 | 0 | BeFree |
Kidney Diseases | 0.000271442 | 1 | 0 | BeFree |
Chronic Lymphocytic Leukemia | 0.000271442 | 1 | 0 | BeFree |
Myeloid Leukemia | 0.000271442 | 1 | 0 | BeFree |
Leukopenia | 0.000271442 | 1 | 0 | BeFree |
Lymphoma, Follicular | 0.000271442 | 1 | 0 | BeFree |
Mucocutaneous Lymph Node Syndrome | 0.000271442 | 1 | 0 | BeFree |
Myositis | 0.000271442 | 1 | 0 | BeFree |
Obesity | 0.000271442 | 1 | 0 | BeFree |
Degenerative polyarthritis | 0.000271442 | 1 | 0 | BeFree |
Papilloma | 0.000271442 | 1 | 0 | BeFree |
Peritonitis | 0.000271442 | 1 | 0 | BeFree |
Vitamin A Deficiency | 0.000271442 | 1 | 0 | BeFree |
Small cell carcinoma of lung | 0.000271442 | 1 | 0 | BeFree |
Atrophic condition of skin | 0.000271442 | 1 | 0 | BeFree |
Glomerulosclerosis (disorder) | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of female breast | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of lung | 0.000271442 | 1 | 0 | BeFree |
Dermatomyositis, Childhood Type | 0.000271442 | 1 | 0 | BeFree |
Restenosis | 0.000271442 | 1 | 0 | BeFree |
Senile Plaques | 0.000271442 | 1 | 0 | BeFree |
Pneumonia due to Klebsiella pneumoniae | 0.000271442 | 1 | 0 | BeFree |
Sleep Apnea, Obstructive | 0.000271442 | 1 | 0 | BeFree |
Carcinoma of lung | 0.000271442 | 1 | 0 | BeFree |
Pseudomonas aeruginosa infection | 0.000271442 | 1 | 0 | BeFree |
Bacterial keratitis | 0.000271442 | 1 | 0 | BeFree |
Vascular inflammations | 0.000271442 | 1 | 0 | BeFree |
Spondylarthropathies | 0.000271442 | 1 | 0 | BeFree |
Severe Sepsis | 0.000271442 | 1 | 0 | BeFree |
Leukemia, B-Cell | 0.000271442 | 1 | 0 | BeFree |
Promyelocytic leukemia | 0.000271442 | 1 | 0 | BeFree |
Juvenile dermatomyositis | 0.000271442 | 1 | 0 | BeFree |
Plaque, Amyloid | 0.000271442 | 1 | 0 | BeFree |
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