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The Sec1/Munc18 Protein Groove Plays a Conserved Role in Interaction with Sec...

Weber-Boyvat(Marion),Chernov(Konstantin G)... Traffic 2016-10-18

...Sec1p groove was required for the plasma membrane targeting of Sro7p-SNARE complexes. Simultaneous inactivation of Sec1p...

Reconciling the regulatory role of Munc18 proteins in SNARE-complex assembly.

Rehman(Asma),Archbold(Julia K),Hu(Shu-Hong... IUCrJ 2014-12-08

...Sec1p/Munc18 (SM) and (2) the soluble N-ethylmaleimide-sensitive attachment protein receptor (SNARE) proteins. Whilst th...

Molecular genetic analysis of vesicular transport in Aspergillus niger reveal...

Kwon(Min Jin),Arentshorst(Mark),Fiedler(Ma... Microbiology 2014-09-19

...Sec1p, Sec8p and Sso1/2p, respectively) showed that these genes are essential for A. niger, similar to the situation in ...

A conserved regulatory mode in exocytic membrane fusion revealed by Mso1p mem...

Weber-Boyvat(Marion),Zhao(Hongxia),Aro(Nin... Mol Biol Cell 2013-07-23

...Sec1p/Munc18 control and SNARE complex assembly are not well understood. We provide evidence that Mso1p, a Sec1p- and Se...

Engineering of vesicle trafficking improves heterologous protein secretion in...

Hou(Jin),Tyo(Keith),Liu(Zihe),Petranovic(D... Metab Eng 2012-07-03

...Sec1p, the SM protein that is involved in vesicle trafficking from Golgi to cell membrane, improves the secretion of het...

Munc18-1 mutations that strongly impair SNARE-complex binding support normal ...

Meijer(Marieke),Burkhardt(Pawel),de Wit(He... EMBO J 2012-06-25

...Sec1p/Munc18 protein Munc18-1, but it is unclear whether Munc18-1 primarily operates as a integral part of the fusion ma...

Resolving the function of distinct Munc18-1/SNARE protein interaction modes i...

Schollmeier(Yvette),Krause(Jean Michel),Kr... J Biol Chem 2011-10-25

Sec1p/Munc18 proteins and SNAP receptors (SNAREs) are key components of the intracellular membrane fusion machinery. Com...

Sec1p and Mso1p C-terminal tails cooperate with the SNAREs and Sec4p in polar...

Weber-Boyvat(Marion),Aro(Nina),Chernov(Kon... Mol Biol Cell 2011-06-03

...Sec1p has a C-terminal tail that is missing in its mammalian homologues. Here we show that deletion of the Sec1p tail (a...

Munc18-1 and syntaxin1: unraveling the interactions between the dynamic duo.

Smyth(Annya M),Duncan(Rory R),Rickman(Coli... Cell Mol Neurobiol 2011-04-14

...Sec1p/Munc18 (SM) protein family which selectively bind to syntaxin isoforms. From their initial identification, the SM ...

Yeast Sec1p functions before and after vesicle docking.

Hashizume(Kristina),Cheng(Yi-Shan),Hutton(... Mol Biol Cell 2010-02-12

...Sec1p seems to function only after vesicles are docked and SNARE complexes are assembled. Here, we show that yeast Sec1p...

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