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Geranylgeranylated, but not farnesylated, RhoB suppresses Ras transformation of…

Mazières(J),Tillement(V),Allal(C),Clanet(C),… Exp Cell Res 2005-04-01

...RhoB-GG, but not by RhoB-F, providing further support for the opposing role of RhoB-F and RhoB-GG in Ras malignant trans...

Farnesyltransferase inhibitors alter the prenylation and growth-stimulating fun…

Lebowitz(PF),Casey(PJ),Prendergast(GC),Thiss… J Biol Chem 1997-06-20

...RhoB in cells. This issue is complex because farnesylated and geranylgeranylated forms of RhoB (RhoB-F and RhoB-GG) both...

Critical functions of RhoB in support of glioblastoma tumorigenesis.

Ma(Y),Gong(Y),Cheng(Z),Loganathan(S),Kao(C),… Neuro Oncol 2015-04-00

...RhoB or a constitutively active mutant (RhoB-V14) did not significantly affect cell growth, which suggests that RhoB is ...

RhoB is regulated by hypoxia and modulates metastasis in breast cancer.

Ju(JA),Godet(I),DiGiacomo(JW),Gilkes(DM) Cancer Rep (Hoboken) 2020-00-00

...RhoB mRNA and protein expression resulting in increased levels of activated RhoB. Both loss of RhoB and gain of RhoB exp...

RhoB plays a central role in hyperosmolarity-induced cell shrinkage in renal ce…

Centrone(M),Saltarella(I),D'Agostino(M),Rani… J Cell Physiol 2024-09-00

...RhoB can be subjected to either geranylgeranylation (RhoB-GG) or farnesylation (RhoB-F), making that the only target of ...

Farnesyltransferase inhibitors disrupt EGF receptor traffic through modulation …

Wherlock(M),Gampel(A),Futter(C),Mellor(H) J Cell Sci 2004-07-01

...RhoB exists as two prenylated forms in cells: geranylgeranylated RhoB (RhoB-GG) and farnesylated RhoB (RhoB-F). Here we ...

RhoB loss prevents streptozotocin-induced diabetes and ameliorates diabetic com…

Bravo-Nuevo(A),Sugimoto(H),Iyer(S),Fallon(Z)… Am J Pathol 2011-01-00

...RhoB dependent. We induced β-cell depletion in RhoB(+/+), RhoB(+/-), and RhoB(-/-) mice with streptozotocin (STZ). Diabe...

Role of RHOB in the antiproliferative effect of glucocorticoid receptor on macr…

Wang(X),Chen(Y),Wang(Y),Zhu(X),Ma(Y),Zhang(S… J Endocrinol 2009-01-00

...Rhob expression vector (Rhob-wt) or constitutively activated Rhob plasmid (Rhob-V14) resulted in decreased proliferation...

RhoB is involved in lipopolysaccharide-induced inflammation in mouse in vivo an…

Wang(XH),Wang(Y),Diao(F),Lu(J) J Physiol Biochem 2013-06-00

...RhoB and inflammation. In this study, the mRNA and protein levels of RhoB were induced by lipopolysaccharide (LPS) in RA...

Ras-related GTPase RhoB forces alkylation-induced apoptotic cell death.

Fritz(G),Kaina(B) Biochem Biophys Res Commun 2000-02-24

...RhoB in cellular defense, cells stably overexpressing wild-type RhoB protein were generated. Overexpression of RhoB rend...

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