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Therapeutic Potential of the Deubiquitinase BRCC3 in Attenuating Ischemic Myo...

Yao(D),Wang(S),Li(R),Pan(X),Chen(Z),Yuan(M... Research (Wash D C) 2026-00-00

...BRCC3 expression was markedly down-regulated after AMI. Cardiac-specific BRCC3 overexpression inhibited TGF-β1/Smad3 act...

Thiolutin alleviates acute graft-versus-host disease (aGVHD) in a mouse model...

Li(X),Zhao(K),Gao(R),Lv(ZC),Wang(Q),Ren(GM... Blood Sci 2026-12-00

...BRCC3-containing isopeptidase complex and thereby suppresses NLR pyrin domain-containing protein 3 (NLRP3) inflammasome ...

Proximity labeling reveals non-catalytic interactions between DPP9 and ubiqui...

Wirtgen(VE),Saied(L),Zolg(S),Alonso(MC),Ma... Cell Mol Life Sci 2026-02-04

...BRCC36/BRCC3 and ABRO1/ABRAXAS2 as novel DPP9 interactors. Furthermore, NanoBRET assays in living cells demonstrated tha...

Paeonol alleviates pulmonary arterial hypertension by activation of BRCC3.

Yin(Q),Xiong(Z),Wang(X),Wei(TW),Chao(J),Ji... Phytomedicine 2026-03-00

...BRCC3). Paeonol binding promotes the stability of BMP receptors and restores the BMP/TGF-β signaling balance. Paeonol at...

Efficacy of leucine-rich high protein supplementation on body composition and...

Chung(SX),Shahar(S),Ajit Singh(DK),Malek R... Eur J Nutr 2026-01-02

...BRCC3) were significantly up-regulated in intervention group (p < 0.05). Leucine-rich high protein supplementation did n...

Thiolutin ameliorates postoperative cognitive dysfunction induced by intestin...

Su(Z),Li(S),Wen(J),Chen(Z),Luo(Z),Tang(H) Arch Biochem Biophys 2026-08-00

...BRCC3/NLRP3 pathway in both intestinal and cerebral tissues, suggesting a potential link. THL protects against IIR-induc...

BRCC3 promotes progression and immune evasion in non-small cell lung cancer t...

Liu(K),Shen(Q),Wei(C),Meng(C),Zhou(A),Liu(... J Mol Histol 2026-07-03

...BRCC3 upregulation correlated with advanced NSCLC, nodal spread, and worse survival. BRCC3 knockdown suppressed malignan...

BRISC Deficiency Drives Heart Failure by Regulating β-Catenin K63 Ubiquitinat...

Liu(L),Ren(GM),Chen(C),Liu(GY),Niu(WH),Yan... Hypertension 2026-06-00

...BRCC3 [BRCA1/BRCA2-containing complex subunit 3] isopeptidase complex), a K63-specific deubiquitinase, in hypertensive c...

In silico analysis of gene expression signatures and drug repurposing associa...

Majeed(KA),Majeed(RA),Ibrahim(TK),Khan(NU) Naunyn Schmiedebergs Arch P... 2026-07-00

...BRCC3, and H3-3B, whereas notable downregulated genes included ZNF709, CD84, STARD8, EPOR, and HAVCR2. The high-confiden...

Post-transcriptional knockdown of BRCC3 via siRNA-loaded niosomes modulates a...

Gürel(Ç),Tut(E),Kuşçu(GC),Buhur(A),Germiya... J Drug Target 2026-05-07

...BRCC3) in PD-related mechanisms such as ubiquitin-proteasome system dysfunction. This study aimed to evaluate the therap...

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