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DNA ligase IV binds to XRCC4 via a motif located between rather than within i...

Grawunder(U),Zimmer(D),Lieber(M R) Curr Biol 1998-11-20

...BRCA1 carboxyl terminus) domains. BRCT domains were initially identified in the breast cancer susceptibility protein BRC...

Mutation-selection balance with multiple alleles.

Clark(A G) Genetica 1998-10-02

...BRCA1), cystic fibrosis (CFTR), muscular dystrophy (DZM), and phenylketonuria (PAH). These observations raise the classi...

Optimization of PCR and electrophoresis conditions enhances mutation analysis...

Lallas(T A),Buller(R E) Mol Genet Metab 1998-09-14

Single-strand confirmation polymorphism (SSCP) analysis on MDE gels has been extensively used to detect BRCA1 gene mutat...

Distal chromosome 17q loss in Barrett's esophageal and gastric cardia adenoca...

Petty(E M),Kalikin(L M),Orringer(M B),Beer... Mol Carcinog 1998-09-15

...BRCA1-SSTR2-D17S2058-D17S929-D17S722-+ ++D17S937-D17S802-tel. Over 50% of the Barrett's and cardia adenocarcinomas demon...

A BRCA1 founder mutation, identified with haplotype analysis, allowing genoty...

Dørum(A),Møller(P),Kamsteeg(E J),Scheffer(... Eur J Cancer 1998-06-16

...BRCA1 region. Of the affected 33 index women, 13 (39.4%) shared one haplotype. In five (15% of total), an identical muta...

Cancer genetics in the new era of molecular biology.

Lynch(H T),Fusaro(R M),Lynch(J F) Ann N Y Acad Sci 1998-06-23

...BRCA1 and BRCA2 in hereditary breast cancer are responsible for an increasing percentage of common solid tumors. A potpo...

Breast cancer genes: therapeutic strategies.

Holt(J T) Ann N Y Acad Sci 1998-06-23

...BRCA1 is a tumor-suppressor gene. Strategies designed to increase BRCA1 expression or development of BRCA1-mimetic agent...

Predictive genetic tests: problems and pitfalls.

Davis(J G) Ann N Y Acad Sci 1998-06-23

...BRCA1 and BRCA2 genes in families at high risk for breast and ovarian cancer is presented to illustrate the issues of th...

Regulation of BRCA1 and BRCA2 expression in human breast cancer cells by DNA-...

Andres(J L),Fan(S),Turkel(G J),Wang(J A),T... Oncogene 1998-06-16

...BRCA1 and BRCA2 mRNA levels. Decreased levels of BRCA1 and BRCA2 mRNAs were observed within 6-12 h after treatment with ...

The BRCA2 is a histone acetyltransferase.

Siddique(H),Zou(J P),Rao(V N),Reddy(E S) Oncogene 1998-06-16

...BRCA1 or BRCA2 tumor suppressor genes have shown to have high risk in developing breast and ovarian cancers. Two potenti...

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