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TP53 BRCA1 CRISPR single-cell cancer

Warner(E),Foulkes(W),Goodwin(P),Meschino(W... J Natl Cancer Inst 1999-08-19

Approximately 2.0%-2.5% of Ashkenazi Jewish women carry one of three founding mutations in the BRCA1 and BRCA2 genes, an...

Yuan(S S),Lee(S Y),Chen(G),Song(M),Tomlins... Cancer Res 1999-09-07

...BRCA1 and BRCA2 account for the majority of familial breast cancers. Cells with mutated BRCA1 or BRCA2 are hypersensitiv...

Csokay(B),Tihomirova(L),Stengrevics(A),Sin... Hum Mutat 1999-09-21

...BRCA1 gene, using combined Heteroduplex Analysis/SSCP followed by direct sequencing of the variants. BRCA1 germ-line mut...

Noguchi(S),Kasugai(T),Miki(Y),Fukutomi(T),... Cancer 1999-05-27

...BRCA1-associated HBCs (32%) and BRCA2-associated HBCs (29%) than in the control group (6%). BRCA1-associated HBCs showed...

Xu(X),Wagner(K U),Larson(D),Weaver(Z),Li(C... Nat Genet 1999-05-25

Cre-mediated excision of exon 11 of the breast-tumour suppressor gene Brca1 in mouse mammary epithelial cells causes inc...

Buchholz(T A),Weil(M M),Story(M D),Strom(E... Radiat Oncol Investig 1999-07-12

...BRCA1, BRCA2, or ATM, has been determined to be one mechanism of breast carcinogenesis. It has been established that inh...

Fan(S),Wang(J),Yuan(R),Ma(Y),Meng(Q),Erdos... Science 1999-06-18

Mutations of the breast cancer susceptibility gene BRCA1 confer increased risk for breast, ovarian, and prostatic cancer...

Zhong(Q),Chen(C F),Li(S),Chen(Y),Wang(C C)... Science 1999-08-16

...BRCA1 but was restored by transfection of wild-type BRCA1. Ectopic expression of wild-type, but not mutated, BRCA1 in th...

Carter(C L),Hailey(B J) Women Health 1999-08-19

...BRCA1 and BRCA2 genes. Although still largely limited to research programs, widespread commercial testing and incorporat...

Thornton(K),Forstner(M),Shen(M R),West(M G... Protein Expr Purif 1999-08-18

...BRCA1 carboxyl terminus) domain superfamily. These two regions of XRCC1 have been shown to interact independently with D...

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