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Somatic Mutation Spectrum of Non-Small-Cell Lung Cancer in African Americans:...

Araujo(Luiz H),Lammers(Philip E),Matthews-... J Thorac Oncol 2016-09-15

...PIK3CA (0.8%), BRAF, NRAS, ERBB2, and AKT1 (0.4% each). ALK translocations were detected in two nonsquamous tumors (1.7%...

Prognostic Value of BRAF, PI3K, PTEN, EGFR Copy Number, Amphiregulin and Epir...

Llovet(Patricia),Sastre(Javier),Ortega(Jul... Mol Diagn Ther 2016-09-05

...PIK3CA, phosphatase and tensin homolog (PTEN), amphiregulin (AREG), and epiregulin (EREG)] in 105 patients with mCRC KRA...

Pre-trial inter-laboratory analytical validation of the FOCUS4 personalised t...

Richman(Susan D),Adams(Richard),Quirke(Phi... J Clin Pathol 2016-04-11

...PIK3CA codons542/545/546/1047, generated highly concordant results. Two samples gave discrepant results; in one a PIK3CA...

Evaluation of efficacy and safety markers in a phase II study of metastatic c...

Lambrechts(Diether),Thienpont(Bernard),Thu... Br J Cancer 2016-01-04

...PIK3CA and PIK3R1 did not significantly correlate with PFS (multiple testing-adjusted false discovery rate (FDR) or mult...

Multiple Mutations Detected Preoperatively May Predict Aggressive Behavior of...

Shrestha(Rupendra T),Karunamurthy(Arivaras... Thyroid 2016-09-26

...PIK3CA (p.H1047R), and AKT1 (p.E17K). Presence of multiple oncogenic mutations in the FNA specimen was highly indicative...

Tumors with AKT1E17K Mutations Are Rational Targets for Single Agent or Combi...

Davies(Barry R),Guan(Nin),Logie(Armelle),C... Mol Cancer Ther 2016-09-06

...PIK3CA mutations in breast epithelial cells. Moreover, the therapeutic potential of AKT inhibitors in human tumors with ...

Detection of a mosaic PIK3CA mutation in dental DNA from a child with megalen...

McDermott(John H),Byers(Helen),Clayton-Smi... Clin Dysmorphol 2016-09-28

...PIK3CA occurring during embryogenesis. Standard sequencing technologies are relatively poor at indentifying sequence cha...

Prognostic role of PIK3CA mutations of cell-free DNA in early-stage triple ne...

Takeshita(Takashi),Yamamoto(Yutaka),Yamamo... Cancer Sci 2016-06-07

...PIK3CA mutations for TNBC patients. We investigated the PIK3CA major mutation status of cfDNA as a noninvasive biomarker...

Did circulating tumor cells tell us all they could? The missed circulating tu...

Fina(Emanuela),Reduzzi(Carolina),Motta(Ros... Int J Biol Markers 2016-09-07

...PIK3CA, AKT2 and ALDH1) was evaluated in addition to EPCAM, MUC1 and ERBB2. When the physical properties of tumor cells ...

Epstein-Barr Virus-Associated Gastric Carcinoma: Use of Host Cell Machineries...

Abe(Hiroyuki),Kaneda(Atsushi),Fukayama(Mas... Pathobiology 2016-07-11

...PIK3CA and ARID1A, mutation in BCOR, and amplification of PD-L1 and PD-L2. Although currently undetermined, the virus mi...

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