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BRCA1-associated growth arrest is RB-dependent.

Aprelikova(O N),Fang(B S),Meissner(E G),Co... Proc Natl Acad Sci U S A 1999-11-24

...BRCA1 inhibits growth of some but not all cell lines. In an attempt to uncover the mechanism of growth suppression by BR...

Role of direct interaction in BRCA1 inhibition of estrogen receptor activity.

Fan(S),Ma(Y X),Wang(C),Yuan(R Q),Meng(Q),W... Oncogene 2001-03-29

...BRCA1 and in a breast cancer cell line that lacks endogenous functional BRCA1 (HCC1937). In addition, BRCA1 blocked the ...

Hyperplasia and spontaneous tumor development in the gynecologic system in mi...

Kim(Sang Soo),Cao(Liu),Lim(Sung-Chul),Li(C... Mol Cell Biol 2006-09-28

...BRCA1 locus generates multiple protein products including BRCA1-Delta11, which is identical to the BRCA1 full-length iso...

A mouse model for the molecular characterization of brca1-associated ovarian ...

Xing(Deyin),Orsulic(Sandra) Cancer Res 2006-11-28

...Brca1 wild-type and Brca1-deficient cells. The Brca1 wild-type and Brca1-deficient mouse ovarian tumors and cell lines p...

NF-κB is a critical mediator of BRCA1-induced chemoresistance.

Harte(M T),Gorski(J J),Savage(K I),Purcell... Oncogene 2014-06-26

BRCA1 mediates resistance to apoptosis in response to DNA-damaging agents, causing BRCA1 wild-type tumours to be signifi...

Proliferation and ovarian hormone signaling are impaired in normal breast tis...

Communal(Laudine),Vilasco(Myriam),Hugon-Ro... Oncotarget 0000-00-00

...BRCA1 mutations (BRCA1+/mut, n=23) or without BRCA1 mutations (BRCA1+/+, n=28). BRCA1+/mut tissues showed an increased p...

Regulation of BRCA1 phosphorylation by interaction with protein phosphatase 1...

Liu(Ying),Virshup(David M),White(Raymond L... Cancer Res 2002-12-17

...BRCA1 after ionizing radiation, indicating that PP1alpha dephosphorylates BRCA1 in vivo. BRCA1 and PP1alpha reciprocally...

Impaired DNA damage response in cells expressing an exon 11-deleted murine Br...

Huber(L J),Yang(T W),Sarkisian(C J),Master... Mol Cell Biol 2001-06-28

...Brca1 protein. Our results demonstrate that full-length murine Brca1 is identical to human BRCA1 with respect to its cel...

The retinoblastoma gene undergoes rearrangements in BRCA1-deficient basal-lik...

Jönsson(Göran),Staaf(Johan),Vallon-Christe... Cancer Res 2012-12-04

...BRCA1/2 mutation carriers. Focusing on the RB1 locus, we analyzed 33 BRCA1-mutated, 36 BRCA2-mutated, and 48 non-BRCA1/2...

Interplay among BRCA1, SIRT1, and Survivin during BRCA1-associated tumorigene...

Wang(Rui-Hong),Zheng(Yin),Kim(Hyun-Seok),X... Mol Cell 2008-11-12

...BRCA1 predispose women to breast and ovarian cancers. However, the downstream mediators of BRCA1 function in tumor suppr...

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