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Li(X),Huang(T) Breast Cancer 2025-11-00

...PIK3CA gene, cross-talk between ER and HER2 signaling, and activation of alternative growth pathways. Ongoing research a...

Theurer(S),Schildhaus(HU),Herold(T),Brande... Pathol Res Pract 2025-11-00

...PIK3CA, but co-occurred with TP53 mutations and TERT promoter mutations. MET alterations in ATC have been poorly describ...

Zhao(T),Akgul(M),Siegmund(SE) Histopathology 2025-11-00

...PIK3CA signalling pathway genes (5/7 cases). Actionable variants were present in 6/7 cases. Classification utilizing imm...

Angerilli(V),Gasparello(J),Collesei(A),Cec... Mod Pathol 2025-11-00

...PIK3CA (41%) and ARID1A (17%). Transcriptomic analysis revealed substantial differential gene expression between EBVaGCs...

Koo(SC),Ma(J),Tran(QT),Alaggio(R),Stracuzz... Head Neck Pathol 2025-09-04

...PIK3CA hotspot mutations in two cases (p.R88Q, p.R38H) and a truncating FGFR2 variant (p.L776Rfs) in one. The single tum...

Fusco(N),Guerini-Rocco(E),Castellano(I),Ma... Virchows Arch 2025-10-00

The PTEN tumor suppressor regulates the PIK3CA/AKT1 pathway, and its inactivation significantly contributes to tumorigen...

Noman(AM),Sultan(MT),Zafar(S),Maaz(M),Mazh... Food Sci Nutr 2025-09-00

...PIK3CA expression. In lung cancer (LC), they act as SphK1 inhibitors in NSCLC H1299 and A549 cell lines. Additionally, t...

Appierto(V),Tamborini(E),Tiberio(P),Busico... Front Oncol 2025-00-00

...PIK3CA (50%), TP53 (30.7%), and PTEN (5.9%). Six patients developed LRR as first event; 4 distant metastases. In all LRR...

Freckelton(J),Mencel(J),Levink(I),Rao(S),F... Curr Oncol 2025-09-12

...PIK3CA mutation (33% vs. 8%, p = 0.02). Mismatch repair deficiency was more common in patients with V600BRAF mutations t...

Rivero(DA),Tomsich(JL),Benegas(PA),Gallard... Gene 2025-10-15

...PIK3CA expression were observed among different cancer types. These findings suggest that PIK3CA and PTEN may serve as p...