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Martling(A),Hed Myrberg(I),Nilbert(M),Grön... N Engl J Med 2025-09-18

...PIK3CA mutations. However, data from randomized trials are lacking. We conducted a double-blind, randomized, placebo-con...

Chiru(ED),Sojak(L),Landin(J),Vetter(M),Gra... Front Oncol 2025-00-00

...PIK3CA pathway alterations, drugs like alpelisib, capivasertib, and inavolisib have recently been approved, demonstratin...

Podany(P),Zhan(H),Ai(D),Krishnamurti(U),Li... Pathol Res Pract 2025-11-00

...PIK3CA mutations in 4 of 6 cases with conversion from positive to negative. Our study demonstrated that the liver is a m...

Sun(F),Banwait(MK),Singhal(S),Herrmann(A),... Lung Cancer 2025-10-00

...PIK3CA, but not TP53 alone, demonstrated significantly shorter median OS compared to the TP53 and PIK3CA wild-type popul...

Zhao(T),Akgul(M),Siegmund(SE) Histopathology 2025-11-00

...PIK3CA signalling pathway genes (5/7 cases). Actionable variants were present in 6/7 cases. Classification utilizing imm...

Ubaid(S),Kushwaha(R),Kashif(M),Singh(V) Cancer Genet 2025-11-00

...PIK3CA, as well as tumor suppressor genes like TP53, PTEN, and CDKN2A, highlighting their molecular mechanisms and roles...

He(F),Su(S),Song(R),Li(Y),Zou(L),Li(Z),Xia... Antioxidants (Basel) 2025-08-29

...PIK3CA, EGFR, and MAPK1 to regulate T2DM pathways. Molecular docking confirmed strong binding affinities between these c...

Singh(A),Choudhary(KK) In Silico Pharmacol 2025-00-00

...PIK3CA) involved in tumour growth, cell proliferation, and survival via the PI3K-Akt, MAPK, and androgen receptor pathwa...

Qin(Z),Li(L),Wang(C) Medicine (Baltimore) 2025-09-05

...PIK3CA: -8.2 kcal/mol; and CYP3A4: -8.1 kcal/mol), indicating that it might inhibit LUAD by influencing kinase and metab...

Alkhatib(M),Hua(L),Beyer(F),Prilop(I),Podl... J Neurosurg 2025-12-01

...PIK3CA/PIK3R1 (19 cases, 15.4%; 14 PIK3CA and 5 PIK3R1), TRAF7 alone (7 cases, 5.7%), POLR2AQ403K (4 cases, 3.3%), and T...