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Unlocking the Anti-Breast Cancer Potential of Aralia chinensis L.

Xue(J),Li(L),Shu(Y),Xie(C),Lu(T),Chai(H) Curr Issues Mol Biol 2025-08-16

...PIK3CA, STAT3, and EGFR. In MCF-7 cells, TSAC suppressed proliferation and migration while downregulating Src, PI3K, and...

Exploring the mutational spectrum of key kinase genes PIK3CA, BRAF, EGFR, ALK...

Nawab(F),Naeem(W),Fatima(S),Ali(A),Khalil(... BMC Cancer 2025-08-18

...PIK3CA, BRAF, EGFR, ALK, and ROS1) for mutations exploration in the OSCC patients belonging to Khyber Pakhtunkhwa (KP) t...

Proteogenomic characterization of invasive breast tumors in young women.

Raj-Kumar(PK),Liu(J),Soltis(AR),Bateman(NW... NPJ Breast Cancer 2025-08-18

...PIK3CA mutations were more common in luminal tumors from older women. Young women's tumors exhibited lower estrogen rece...

ARID1A mutation drives gastric tumorigenesis via activating type 2 immune dom...

Arai(J),Hayakawa(Y),Suzuki(N),Kinoshita(H)... iScience 2025-08-15

...PIK3CA mutations and CDKN2A silencing. However, the role of these alterations in the development of GC remains unclear. ...

Genomic landscapes of breast cancer in African populations: a systematic review.

Mugo(N),Contino(G) NPJ Breast Cancer 2025-08-14

...PIK3CA mutations compared with TCGA White. African tumours also exhibited elevated TMB, CNA and SV burden. Mutational si...

Pediatric Embryonal Rhabdomyosarcoma: An Integrated Study of Clinicopathologi...

Yang(B),Schmidt(RJ),Raca(G),Shillingford(N... Virchows Arch 2025-08-14

...PIK3CA, and TP53 genes in 1 case each. Case 1 had heterologous cartilaginous differentiation with germline mutation in C...

A Subset of Serous Tubal Intraepithelial Carcinoma (STIC)-Like Lesions and Co...

da Silva(EM),Da Cruz Paula(A),Dessources(K... Mod Pathol 2025-11-00

...PIK3CA mutations. Immunohistochemical analysis revealed that the HG-EC of case 5 lacked WT1 expression and had aberrant ...

Molecular Characterization of NUT Carcinoma: A Report from the NUT Carcinoma ...

Kim(JJ),Walton(SA),Mahadevan(NR),Haradon(J... Clin Cancer Res 2025-09-15

...PIK3CA, RET, and FGFR3 and tumor suppressors ATM and BRCA1 (n = 1 each). Secondary genes altered in >5% of NCs included ...

Durvalumab versus Physician's Choice Chemotherapy in Recurrent Ovarian Clear ...

Ngoi(NYL),Choi(CH),Zhu(J),Lim(D),Tan(TZ),S... Clin Cancer Res 2025-09-15

...PIK3CA mutations were associated with time to progression on durvalumab ≥12 weeks [relative risk (mutated vs. wild-type)...

High-Flow and Low-Flow Cerebrovascular Malformations Syndromes Associated Wit...

Palermo(M),Olivi(A),Sturiale(CL) Pediatr Neurol 2025-12-00

...PIK3CA mutations were observed in KTS cases, while Ras GTPase-activating protein 1 mutations were more common in PWS. Ce...

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