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Chen(H) Am J Cancer Res None

...BRCA1/2 mutations or broader homologous recombination deficiency (HRD), where synthetic lethality can be therapeutically...

Xu(J),Sun(J),Tang(J),Huai(W),Gao(Y),Yao(R)... Clin Chim Acta 2026-07-07

...BRCA1 (20%), and Lynch syndrome genes PMS2 (13%) and MSH6 (6%). Most variants were loss-of-function (78%) and inherited ...

Cicin(I),Bahsi(T),Kose(F),Kus(T),Eralp(Y),... Sci Rep 2026-07-07

BRCA1/2 germline pathogenic variants confer markedly elevated lifetime risks for breast, ovarian, prostate, and pancreat...

Hill(N),AlMuallim(HYO),Maddock(E),Hobbs(C)... FEBS Open Bio 2026-07-08

...BRCA1, while also attenuating neuroinflammatory activation. In addition, KCL-286 normalises microglial and astrocytic mo...

Chitphuk(S),Stitchantrakul(W),Wikiniyadhan... Comput Struct Biotechnol J None

...BRCA1-deficient cells. Crucially, the pipeline correctly classified ZINC67913374 as biologically inactive [median inhibi...

Wang(K),Geng(S),Xiao(Z),Jiang(H),Jiang(H) Mol Cell Biochem 2026-08-00

...BRCA1 and RAD51, and upregulates glycolytic regulators LDHA and HK2, thereby augmenting DNA damage repair capacity and g...

Betella(I),Fumagalli(D),Rappa(A),Sala(I),C... Int J Gynecol Cancer 2026-08-00

...BRCA1/2 mutation testing using SOPHiA DDM Homologous Recombination Deficiency Solution. Functional homologous recombinat...

Paixão(D),Barth(AL),Kiss(A),Monteleone(VF)... Sci Rep 2026-07-08

...BRCA1/2, CHEK2, TP53, ATM, and PALB2. Structural variants accounted for 7.6% of all P/LP findings and were predominantly...

Sjoquist(KM),Dobrovic(A),Robledo(KP),Nesic... Br J Cancer 2026-07-08

...BRCA1 (meBRCA1) or RAD51C (meRAD51C) or mutation of non-BRCA HR genes. This trial evaluated olaparib in platinum-sensiti...

Zhang(M),Niu(L),Lyu(H),Liu(Z),Zeng(H),Lu(Z... Chin Med J (Engl) 2026-07-07

...BRCA1/2. Based on dose-limiting toxicities and preliminary efficacy, daily famitinib 10 mg combined with dalpiciclib 100...