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Lu(C),Xu(CR),Zhang(YC),Ke(EE),Sun(YL),Bai(... Biomark Res 2025-07-23

...PIK3CA co-mutations were associated with inferior progression-free survival (PFS; 3.0 vs. 12.4 months, P < 0.001). Super...

Li(WX),Chen(ZX),Jiang(CJ),Li(XZ),Li(XR),Lu... J Nat Prod 2025-07-25

...PIK3CA, and EGFR. And the Western blotting experiment confirmed that 1 could down-regulate key proteins such as Bcl-2, M...

Zhou(X),Liu(Y),Hu(J),Zhang(J),Ren(M),Ji(G)... Curr Oncol 2025-07-27

...PIK3CA mutations were assessed by Sanger sequencing, and immunohistochemistry for ARID1A, HDAC6, Cyclin E1, and p53 was ...

Freeman(TJ),George(TJ),Jacobs(SA),Yothers(... Cancer Chemother Pharmacol 2025-08-09

...PIK3CA (quadruple-wt). NSABP FC-11 is a multi-center, two-arm, phase II study in patients with quadruple-wt mCRC who had...

Basu(S),Sasikumar(S),Sur(S),Vaidya(V),Kheu... Discov Oncol 2025-08-10

...PIK3CA, KRAS, and BRAF activate critical pathways like PI3K/AKT and MAPK/ERK, promoting tumor proliferation and migratio...

Raj-Kumar(PK),Liu(J),Soltis(AR),Bateman(NW... NPJ Breast Cancer 2025-08-18

...PIK3CA mutations were more common in luminal tumors from older women. Young women's tumors exhibited lower estrogen rece...

Nawab(F),Naeem(W),Fatima(S),Ali(A),Khalil(... BMC Cancer 2025-08-18

...PIK3CA, BRAF, EGFR, ALK, and ROS1) for mutations exploration in the OSCC patients belonging to Khyber Pakhtunkhwa (KP) t...

Arai(J),Hayakawa(Y),Suzuki(N),Kinoshita(H)... iScience 2025-08-15

...PIK3CA mutations and CDKN2A silencing. However, the role of these alterations in the development of GC remains unclear. ...

Xu(X),Yan(C),Bian(L),Li(Z),Yu(Y),Zhu(X),Ga... Cancer Res 2025-08-15

...PIK3CA) were commonly altered in IM and matched gastric cancer samples in both IGC and DGC, whereas CDH1 mutations were ...

Shen(M),Hao(Y),Han(X),Wang(B),Li(L),Chen(T... J Immunother Cancer 2025-07-18

...PIK3CA mutations, which are shared across various tumor types, have demonstrated significant immunogenicity and offer gr...