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Tafrihani(AS),Hanif(N),Yoga(IMBK),Irmasari... J Comput Aided Mol Des 2025-07-06

...PIK3CA receptor compared to alpelisib, a known PIK3CA inhibitor. Furthermore, molecular dynamics simulations revealed th...

Qin(Q),Dong(Q),Pan(Y),Wang(C),Lu(J) Sci Rep 2025-07-02

...PIK3CA, and so on) in UC-associated IF. Western blotting confirmed significant reductions in both p-AKT/AKT and p-mTOR/m...

Hassan(A),Aubel(C) Cancers (Basel) 2025-07-03

...PIK3CA or the loss of tumor suppressor PTEN) may lead to its overactivation. Targeted inhibitors of PI3K, Akt and mTOR h...

Fadare(O),Shi(WJ),Protopsaltis(NJ),Song(W) Pathol Res Pract 2025-09-00

...PIK3CA (9/30, 30 %), BRCA2 (4/30, 13.3 %), STK11 (4/30, 13.3 %), ERBB2 (3/30, 10 %), SMAD4 (3/30, 10 %), FBXW7 (3/30, 10...

Gong(W),Zhu(H),Sun(X),Zhang(J),Lin(M),Sun(... Chem Biol Interact 2025-10-22

...PIK3CA) were strongly implicated in phthalate-induced cardiovascular toxicity. Molecular docking analysis further confir...

Heidrich(I),Rautmann(C),Ly(C),Khatri(R),Kö... J Exp Clin Cancer Res 2025-07-12

...PIK3CA variants. Overall tissue-plasma concordance was 51.6%, with more extended biopsy-plasma intervals associated with...

Chaubal(R),Talker(E),Chitra(J),Kadam(R),Ga... Breast Cancer Res Treat 2025-09-00

...PIK3CA and/or TP53 mutations in stem clones of 13 (68.4%) patients. ctDNA analysis in 35 resistant patients identified 2...

Priyadarshini(A),Mohanty(D),Mohanty(S),Ker... Sci Rep 2025-07-09

...PIK3CA, and BCL2 as hub targets. Further,4-hydroxycinnamic acid, 13-hydroxylabda-8(17),14-dien-18-oic acid, labda-8(17),...

Li(X),Yang(C),Wang(L),Ullah(I),Liu(X),Feng... Front Chem 2025-00-00

...PIK3CA, and reduced the protein expression of PI3K and Akt in the PI3K/Akt, indicating effective inhibition of the PI3K/...

Zeng(J),Li(Q),Li(K),Yang(L),Xu(L),Wang(W),... Front Immunol 2025-00-00

...PIK3CA (47.1%) and SPOP (23.5%), but their functions were mutually exclusive. In addition, pathways and genes associated...