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Genetic alterations of prostate cancer: in localized and metastatic prostate ...

Yoon(CE),Kang(S),Rhew(SA),Kwon(HJ),Shin(D)... BMC Urol 2025-07-14

...PIK3CA, LRP6, LRRK2, and APOBEC3B deletion. BRCA2, BCL6, and CHEK2 were significant predictors for BCR. CONCLUSION: Our ...

Identification and modulation of a PI3K/AKT/mTOR pathway-targeting microRNA i...

Mousavikia(SN),M Matin(M),Bahreyni Tossi(M... BMC Cancer 2025-07-14

...PIK3CA, with remarkable changes in gene expression after irradiation. Transfection and irradiation decreased cell surviv...

Tumor-initiating genetics and therapy drive divergent molecular evolution in ...

Chowdhury(T),Tesileanu(CMS),Kocakavuk(E),J... bioRxiv 2025-07-15

...PIK3CA , PIK3R1 , and NOTCH1 were newly acquired in recurrent oligodendrogliomas and associated with increased mutation ...

Breast cancer and large-cell neuroendocrine carcinoma harboring the same PIK3...

Zattarin(E),Beninato(T),Di Liberti(G),Lore... Tumori 2025-12-00

...PIK3CA pathogenic variants in both breast cancer and LCNEC tissues, suggesting a potential relationship as primary tumor...

Genetic profiling and pathway analysis in bladder carcinoma: Implications for...

Vasishta(S),Adiga(US),Augustine(AJ) Turk J Surg 2025-12-08

...PIK3CA, HRAS, FGFR3, and TP53 were implicated across multiple pathways. Metabolite analysis showed significant associati...

Proteomics analysis reveals FEN1 as a promising therapeutic target against sm...

Liu(J),Zhong(M),Yang(K),Wang(J),Ma(H),Wang... Sci Rep 2025-07-30

...PIK3CA, PCNA, and BCL-2 levels, while elevating Caspase-9 expression. CONCLUSION: FEN1 overexpression fuels SCNECC progr...

Clinical Utility of Targeted Next-Generation Sequencing for Determining Human...

Hara(Y),Moro(K),Ichikawa(H),Tsuchida(J),Uc... World J Oncol 2025-08-00

...PIK3CA), serine/threonine kinase 1 (AKT1), and phosphatase and tensin homolog (PTEN) were 7, 3, 6, 1, and 5, respectivel...

Au@Pt@HP1-HP2@Fe3O4 Nanoenzymatic Complexes Based on CHA Signal Amplification...

Wang(X),Sheng(J),Yang(H),Shen(K),Yao(J),Qi... Int J Nanomedicine 2025-00-00

...PIK3CA E542K mutant ctDNA. The assay's performance was validated using gold standard qRT-PCR. Under optimized conditions...

Tumor profiling of advanced urothelial carcinoma: Comparative analysis based ...

Hart(LJ),Barker(K),Ruzdija(D),Bertolo(A),P... Urol Oncol 2025-10-00

...PIK3CA (20.9% vs. 16.7%, P = 0.610), TP53 (62.8% vs. 40.7%, P = 0.041), KDM (18.6% vs. 22.2%, P = 0.802), ARID1A (20.9% ...

Mutational landscape of pure ductal carcinoma in situ and associations with d...

Rizvi(N),Mucaki(EJ),Salmini(EL),Zhang(M),T... Breast Cancer Res 2025-07-08

...PIK3CA, TP53) and genes regulating tissue architecture, which likely enhanced pre-invasive cell fitness but lacked progn...

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