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Simanshu(DK),Xu(R),Stice(JP),Czyzyk(DJ),Fe... Science 2025-07-24

...PIK3CA and in tumors with human epidermal growth factor receptor 2 (HER2) amplification or overexpression. In preclinica...

Huang(M),Wang(X),Lu(Y),Zhou(Q),Liang(J),Li... J Ethnopharmacol 2025-07-24

...PIK3CA, while molecular docking validated their strong binding affinities. KEGG analyses indicated that the PI3K-Akt sig...

Li(WX),Chen(ZX),Jiang(CJ),Li(XZ),Li(XR),Lu... J Nat Prod 2025-07-25

...PIK3CA, and EGFR. And the Western blotting experiment confirmed that 1 could down-regulate key proteins such as Bcl-2, M...

Irham(LM),Adikusuma(W),Illian(DN),Mazaya(M... Sci Rep 2025-07-31

...PIK3CA, JAK2, MTOR, JUN, ERBB2, IGF2, SRC, MDM2, and PARP1) associated with CRC. Molecular docking and molecular dynamic...

Wang(WK),Chang(JM),Ma(XL),Li(GR) Zhongguo Zhong Yao Za Zhi 2025-08-00

...PIK3CA), Toll-like receptor 4(TLR4), protein kinase B1(Akt1), and matrix metallopeptidase 9(MMP9). The results showed si...

Yang(CY),Yang(C),Ge(Z) Zhongguo Shi Yan Xue Ye Xue... 2025-08-00

...PIK3CA, PIK3CB, and AKT2 compared with single-drug therapy. The analysis of GEO database and our center cohort showed th...

Tripathy(D),Blum(JL),Zhang(H),Deng(S),McCu... JCO Precis Oncol 2025-08-00

...PIK3CA, and TP53. CCND1, FGFR1, and EGFR were most frequently amplified. Real-world progression-free survival (rwPFS) wa...

Zhang(M),Huang(X),Dai(M),Zhang(S),Yin(C),Y... Sci Rep 2025-08-07

...PIK3CA, and DS restored the SD-induced abnormal expression of PIK3CA. Our study provides new insights into the developme...

Klocker(EV),Dobrić(N),Graf(R),Beichler(C),... NPJ Breast Cancer 2025-08-07

...PIK3CA mutations and broader genomic profiling. We conducted a prospective, multicenter study analyzing 161 plasma sampl...

Lee(PH),Hsiao(YC),Huang(YH),Hsu(KH),Tseng(... Anticancer Drugs 2025-11-01

...PIK3CA-AKT/RAS-RAF alterations'. Clinical and histopathological data were also collected and analyzed. We studied a tota...