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Conventional and alternative approaches for targeting PIK3CA and PTEN alterat...

Gencel-Augusto(J),Grandis(JR),Johnson(DE) Adv Biol Regul 2026-01-00

...PIK3CA, encoding the p110α catalytic subunit of PI3K enzyme, is altered in approximately 30 % of HNSCC tumors and 37 % o...

Liquid biopsy based on multi-targeted capture of urinary tumor DNA combined w...

Tang(C),Wang(T),Luo(H),Xue(J),Zhu(M),Hong(... Int Urol Nephrol 2026-04-00

...PIK3CA, and TERT, and aberrant methylation in HIST1H4F, NRN1, and POU4F2. Ten machine-learning algorithms were employed ...

Characterization of rutin bindingto HRAS and MAPK3 and its clinical prognosti...

Kamli(H) Naunyn Schmiedebergs Arch P... 2026-02-00

...PIK3CA, MAPK1/3, HRAS), which also exhibited differential expression and prognostic relevance in lung adenocarcinoma dat...

Multi-gene co-mutations of BRAF with TERT, PIK3CA, or TP53 are powerful predi...

Yu(Q),Liu(H) Front Endocrinol (Lausanne) None

...PIK3CA, and/or TP53)-were identified as the strongest independent risk factor for CLNM (odds ratio [OR] = 6.319, 95% con...

Optimizing second-line endocrine-based treatment in HR positive HER2 negative...

Alshehri(A),Altwairgi(AK),AlTourah(A),Alwb... Front Oncol None

...PIK3CA, AKT, BRCA, ESR1) to guide therapy, prioritizing targeted agents such as oral SERDs and PI3K/AKT inhibitors in se...

Definitions of, Advances in, and Treatment Strategies for Breast Cancer Oligo...

Shien(T),Nakamoto(S),Fujiwara(Y),Kosaka(M)... Cancers (Basel) 2025-07-21

...PIK3CA mutations and YAP/TAZ expression. Organ-specific strategies using stereotactic radiotherapy, surgery, and proton ...

In Silico Discovery of a Novel Potential Allosteric PI3Kα Inhibitor Incorpora...

Jia(W),Cheng(X) Biology (Basel) 2025-07-21

...PIK3CA mutations or resistance to immunotherapy, through the precise targeting of mutant PI3Kα. Compared to ATP-competit...

Clinical and pathological analysis of 17 cases of mesonephric-like adenocarci...

Kang(B),Han(B),Shen(D),Zhang(G),Zhang(X) Pathol Res Pract 2025-09-00

...PIK3CA mutation, 1 had a CCND1 mutation, 1 had a CDK6 mutation, 1 had a BCL2L11 mutation, and 1 had a non-specific molec...

Co-Occurring Genomic Alterations in NSCLC: Making Order into a Crowded List.

Attili(I),Fabrizio(FP),Marinis(F) Cancers (Basel) 2025-07-18

...PIK3CA, RB1, and others, that significantly influence disease progression, therapeutic resistance, and clinical outcomes...

Mutation profile and chromosomal abnormality in adenomyosis.

Suda(K),Takahashi(K),Tamura(R),Saito(K),Ya... Reproduction 2025-08-01

...PIK3CA (12.2%), ARID1A (12.1%), and FBXW7 (9.8%) with high mutant allele frequency. In uterine endometrial epithelium, f...

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