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Juric(D),Rugo(HS),Reising(A),Vervier(K),Ma... Ann Oncol 2026-08-00

...PIK3CA-altered cohort. PIK3CA-altered and PIK3CA-wild type tumors had distinct genomic profiles. In the PIK3CA-altered c...

Sha(C),Wei(D),Xu(W),Sun(H),Yin(Y),Su(S),Zh... J Ethnopharmacol 2026-07-15

...PIK3CA. In vivo evaluations, compared with the AMD model group, high-dose ZJP treatment increased the time spent in the ...

Chen(S),Wen(Q),Leng(J),Wang(Q),Tang(P),Lia... Comb Chem High Throughput S... 2026-04-07

...PIK3CA, NRAS, BRAF, PTPN11, CTNNB1, and ESR1 are key targets. It plays a significant role in its resistance to chloasma.

Miao(J),Liu(Q),Zhao(J),Fan(S),Wang(S),Ye(F... Cancer Biol Med 2026-04-07

Accurate detection of PIK3CA mutations is essential for guiding PI3K-targeted therapies in breast cancer, yet sequencing...

Zhao(Y),Wang(H),Wang(Y),Jiang(Y),Hu(X),Sha... Cancer Biol Med 2026-04-07

...PIK3CA, PTEN, and ERBB2 kinase domain mutations. Functional studies confirmed ERBB2 variants (e.g., V777L and E698_P699d...

Chen(M),Li(Y),Liao(L),Du(X) Transl Cancer Res 2026-03-31

...PIK3CA-targeted agents (imatinib, everolimus) showing modest efficacy, while programmed death-1/programmed death-ligand ...

Van Mackelenbergh(MT),Pfarr(N),Weber(K),Un... NPJ Breast Cancer 2026-04-14

...PIK3CA-wt cohort (p = 0.339). In HER2+ breast cancer, PIK3CA mutations were significantly associated with reduced respon...

Shih(CT),Ibanez(KR),Lee(JM),Huang(TT) Cancers (Basel) 2026-03-25

...PIK3CA-mutant cells underwent apoptosis driven by catastrophic DNA damage accumulation, whereas PIK3CA-wildtype cells ex...

Bauer(A),Arndt(A),Reichenbach(L),Gebauer(N... Cancers (Basel) 2026-03-26

...PIK3CA, and APC. CD39 and CD73 expression was frequent and highly variable, occurring on both tumor cells and tumor-infi...

Vrdoljak(E),Pancirov(M),Flam(J),Čerina Pav... Cancers (Basel) 2026-04-03

...PIK3CA-mutated, hormone receptor-positive, HER2-negative metastatic breast cancer. However, on-target hyperglycemia ofte...