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Alirocumab Plus Cemiplimab in Immunorefractory NSCLC: A Single Arm Phase 2 St...

Oduah(E),Gray(J),Stinchcombe(T),Wolf(S),Qi... Res Sq 2026-06-24

...PIK3CA, PTEN, or AKT1 alterations. The ORR in patients with PIK3CA, PTEN, or AKT1 alterations (n=17) was 29.4% (95% CI, ...

Neuroendocrine Carcinoma of Cervix: Comprehensive Review of Epidemiology, Pat...

Dayani(D),Ramani(N),Hage(MAC),Virarkar(M),... Semin Ultrasound CT MR 2026-07-03

...PIK3CA, KRAS, and the Rb and DNA damage response pathways. Immunohistochemical expression of markers such as synaptophys...

Genetic Evolution in BRCA1-Associated Breast Cancer Reveals Early Driver Muta...

Hu(L),Li(Z),Wan(Q),Liao(X),Zhang(Y),Liu(Q)... Cancer Sci 2026-07-03

...PIK3CA and GATA3 alterations. Based on the initiating driver event, BRCA1-associated tumors were classified into three s...

Pan-cancer analysis of tissue-plasma genomic concordance reveals enhanced con...

Zhang(M),Feng(Y),Du(X),Qu(C),Meng(M),Ye(M)... NPJ Precis Oncol 2026-07-03

...PIK3CA) and pathways (RTK-RAS, p53, DNA repair). ctDNA-specific mutations were predominantly subclonal (61.5% vs. 9.7% i...

Mechanism Analysis of Fuzheng Xiaokui Formula in Treating Recurrent Aphthous ...

Wang(Y),Pan(D),Shao(T),Huang(X),Liang(Y),X... Curr Pharm Des 2026-05-25

...PIK3CA, STAT3). Enrichment analysis revealed that the biological processes primarily involved responses to xenobiotic st...

Oncogenic PIK3CA mutations shape an immunoregulatory microenvironment in mosa...

Galasso(I),Bayard(C),Blériot(C),Ladraa(S),... PNAS Nexus 2026-06-00

PIK3CA-related overgrowth spectrum (PROS) comprises a group of rare genetic disorders caused by de novo, mosaic, postzyg...

HLA micropolymorphisms confine neoantigen conformational adaptability and gui...

Ma(J),Ayres(CM),Brambley(CA),Eldaly(B),Per... Proc Natl Acad Sci U S A 2026-06-09

...PIK3CA oncogenic hotspot mutation restricted by HLA-A*03:01 were unable to recognize the same epitope in the context of ...

Discussion on the Potential Mechanism of Wuling Decoction in the Treatment of...

Zhang(M),Xie(B),Wu(L),Wu(X),Zhang(J),Shen(... Endocr Metab Immune Disord ... 2026-05-21

...PIK3CA, and ESR1. GO enrichment yielded 467 significant terms, while KEGG analysis identified 132 pathways, predominantl...

The Mutational Landscape of Angiosarcoma: Challenges and Opportunities to Des...

Pandey(SK),Arya(S),Mishra(A) Curr Mol Med 2026-05-20

...PIK3CA alterations converging to drive aggressive angiogenesis; (2) endothelial-specific dysregulation-TP53-driven disru...

Clinico-genomic nomograms for estimation of survival risk in metastatic castr...

Kohli(M),Shankar(A),Lloyd(J),Wang(L),Huo(X... JNCI Cancer Spectr 2026-05-09

...PIK3CA, PIK3CB, NOTCH1; losses: TMPRSS2, NCOR1, ZBTB18, TP53, NKX3-1) was used to develop an integrated clinico-genomic ...

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