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A phase II study of alpelisib and capecitabine in patients with previously tr...

Lim(AR),Kang(SY),Choi(MK),Lee(MA),Kim(JY),... Sci Rep 2026-06-29

...PIK3CA-mutant metastatic colorectal cancer who had progressed after standard chemotherapy. Patients received oral alpeli...

Clinicopathological and genetic analysis of primary intraosseous carcinoma no...

Yasuda(S),Oya(K),Ikuta(S),Takata(S),Nakata... BMC Oral Health 2026-06-29

...PIK3CA were observed in 60% of cases. Additionally, one patient had high TMB status. Given the challenges in diagnosis a...

Integrated genomic and immunophenotypic profiling reveals monoclonal origin, ...

Zhang(X),Wu(H),Zhao(W),Hu(Z),Wang(G),Li(Y)... Front Immunol None

...PIK3CA (22%) across tumor regions. Shared truncal mutations and copy-number alterations between ACC and SCCC regions sug...

Disruption of Pik3r1 promotes muscle hyperplasia and lipolysis in grass carp ...

Lv(W),Meng(X),Sun(T),Chen(Y),Li(W),Sheng(T... Comp Biochem Physiol A Mol ... 2026-09-00

...Pik3ca in muscle, accompanied by upregulation of PPARα and CPT1a and downregulation of FASN and ACC1 in the liver. Furth...

Slow-flow, high-impact: radiologic features in venous malformations of the fe...

Guihard(M),Fraissenon(A),Collardeau-Fracho... Insights Imaging 2026-06-30

...PIK3CA and TEK). They remain poorly documented and frequently misclassified due to persistent outdated terminology and d...

Case Report: Neoadjuvant chemoimmunotherapy achieving pathological complete r...

Wang(D),Liu(T),Zhao(J),Ding(B),Niu(Y) Front Oncol None

...PIK3CA alterations, exhibited primary resistance to afatinib with radiographic progression after one month. She subseque...

Network pharmacology-guided identification of kinase-mediated vascular signal...

Dhondsekar(D),Mandlik(S),Nilewar(S),Mandli... In Silico Pharmacol None

...PIK3CA, FYN, PTK2, SRC, PTPN11, PIK3R1, CTNNB1, and AKT1, indicating a critical role for kinase-driven vascular signalli...

Clinical, surgical, and molecular characteristics and outcomes of adult patie...

Lin(J),Tang(W),Li(K),Chen(Z),Zhang(H),Ye(Z... J Neurooncol 2026-07-02

...PIK3CA. In the multivariable Cox regression model, postoperative adjuvant radiotherapy (RT + TMZ) emerged as the sole in...

Molecular tumor board-guided osimertinib therapy in EGFR L858R/Q701L-mutant l...

Albers-Leischner(C),Ritgen(M),Paulsen(FO),... Oncologist 2026-08-06

...PIK3CA, ATM, and CTNNB1 and loss of CDKN2A/B, MLH1, and BAP1. To resolve this uncertainty, the EGFR mutations were recre...

Mechanistic insights into a compound essential oil (Lemon-Angelica sinensis-B...

Bai(J),Xu(X),Hou(M),Liu(L) Fitoterapia 2026-09-00

...PIK3CA) were identified. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses revealed signifi...

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