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Common oncogenic mutations in colorectal cancer: drivers of carcinogenesis an...

ALTamimi(AO),Elemam(NM),Hafezi(S),Saber-Ay... Front Pharmacol None

...PIK3CA, and TP53, on tumor progression and highlight their dynamic interactions with the TME, which can modulate, mask, ...

Dysregulated Proline Metabolism Exacerbates Hepatocellular Carcinoma Metastas...

Zhang(H),Gu(L),Su(X),Chen(W),Tan(M),Yu(H),... Cancer Commun (Lond) None

...PIK3CA), AKT serine/threonine kinase 3 (AKT3), and integrin subunit β1 (ITGB1). Importantly, the enhanced protein transl...

Durvalumab plus Paclitaxel, with or without Capivasertib or Oleclumab, in Pat...

Schmid(P),Ma(CX),Park(YH),Lord(S),Armstron... Clin Cancer Res 2026-08-14

...PIK3CA/AKT1/PTEN alterations, and CD73, with a trend for improved activity in the PD-L1-positive subgroups. These findin...

CDK4/6 inhibitors rechallenge post-progression in HR-positive HER2-negative a...

Veta Darkovski(J),Michelon(I),Gazzoni(G),M... Breast Cancer Res 2026-05-27

...PIK3CA alterations demonstrated a median PFS of 5.3 (3.6-7.4) and 4.7 (3.6-6.7) months, respectively. This meta-analysis...

The Current Landscape of Metastatic Breast Cancer: A Pathology Guide on Emerg...

Ferreira(J),Albergaria(A),Schmitt(F) Cancers (Basel) 2026-05-10

...PIK3CA and ESR1, germline/somatic BRCA1/2, and PD-L1 expression. Furthermore, liquid biopsy, particularly the analysis o...

Insulin Pathway Changes in Localized Prostate Cancer: A Multi-Institutional A...

Adler(ER),Mohammad(A),Kumar(P),Rounbehler(... Cancers (Basel) 2026-05-19

...PIK3CA, are mutated in up to 32%, 15%, and 11% of localized prostate tumors, respectively. We aimed to further character...

Potential Efficacy of Luteolin in Cutaneous Squamous Cell Carcinoma: A Combin...

Guo(Y),Wang(X),Gao(Y),Xu(Y),Fang(Z),Liu(S)... Biomolecules 2026-05-18

...PIK3CA, AKT, Bax, and Bcl-2, providing supportive in silico evidence for its potential modulation of EGFR/PI3K/AKT signa...

Molecular Profiling and Targeted Therapeutic Strategies in Breast Cancer: Cli...

Kawczak(P),Bączek(T) J Clin Med 2026-05-12

...PIK3CA-mutated breast cancer and represents a promising strategy in gynecologic tumors with aberrant PI3K/AKT/mTOR pathw...

Capivasertib as a Therapeutic Agent for Breast Cancer: Targeting AKT to Overc...

Damaskos(C),Garmpis(N),Arkadopoulos(N),Mic... J Clin Med 2026-05-15

...PIK3CA, AKT1, or PTEN alterations. Drug combination approaches with paclitaxel or olaparib have demonstrated additive or...

Network Pharmacology and Molecular Docking-Based Investigation of Empaglifloz...

Tedasen(A),Chatatikun(M),Netphakdee(R),Hua... Life (Basel) 2026-04-23

...PIK3CA-which serve as key regulators in CKD pathophysiology. Gene Ontology and KEGG pathway enrichment analyses indicate...

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