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TRERNA1-mediated acetylation represses ferroptosis of non-small cell lung can...

Li(B),Sun(Y) Hum Cell 2026-06-24

...PIK3CA and inhibit ferroptosis. Overexpression of KAT6A or PIK3CA alleviateS the promoting effect of TRERNA1 knockdown o...

Functional characterization of PIK3CA E545A mutation in MCF-7 breast cancer c...

Le(HT),Nghi(NB),My(VD),Vu(HA),Thanh(MC),Tr... Biochem Biophys Res Commun 2026-09-03

...PIK3CA variant. Our study expands the current understanding of PIK3CA-driven oncogenic diversity beyond canonical hotspo...

A novel lactylation-related gene signature deciphers the immunosuppressive mi...

Fu(C),Wang(C) Discov Oncol 2026-06-24

...PIK3CA mutations. Differential expression analysis indicated that this immune exclusion is structurally maintained by en...

6PPD-quinone exposure and Alzheimer's disease: insights from integrative netw...

Zhang(C),Zhang(J) Open Med (Wars) 2026-01-00

...PIK3CA as key hub genes enriched in the cerebral cortex and basal ganglia. Transcriptomic data confirmed differential ex...

Feasibility of PIK3CA Mutation Detection via Microfluidic Isolation of Dissem...

Grollmann(H),Volz(B),Schroth(W),Bahlinger(... Geburtshilfe Frauenheilkd 2026-05-00

...PIK3CA mutation analysis via MassARRAY PIK3CA Breast Panel and digital droplet PCR. PIK3CA mutations were detected in 42...

Prognostic significance of ctDNA mutations in advanced HER2-positive breast c...

Lin(J),Xu(H),Zhou(Y),Sa(Q),Wang(J),Xu(B) Adv Clin Exp Med 2026-06-00

...PIK3CA mutations correlated with worse PFS (HR = 2.12, 95% CI: 1.43-3.15, p = 0.002), whereas ERBB2 mutations showed no ...

Sequential CRISPR-EspCas9-Mediated Wild-Type Depletion Enhances the Detection...

Hong(S),Park(CS),Been(KW),Kang(S),Hong(J),... Biosensors (Basel) 2026-06-10

...PIK3CA H1047R mutations that were undetectable by conventional Sanger sequencing. To evaluate detection sensitivity, we ...

Post-CDK4/6 Inhibitor Therapeutic Approaches in Hormone Receptor-Positive, HE...

Al-Shamsi(HO),Abdelwahed(N),Abdelwahab(SI)... Diagnostics (Basel) 2026-06-10

...PIK3CA-mutated tumors, established the basis for biomarker-guided treatment in hormone receptor-positive, HER2-negative ...

Long-read sequencing bridges germline and somatic variant detection: a multi-...

Koyutourk(B),Çobanoğulları(H),Diker(Ö),Olg... Clin Transl Oncol 2026-06-05

...PIK3CA, EGFR, and KRAS. In parallel, germline sequencing revealed pathogenic or likely pathogenic variants in 60% (30/50...

Expanding the spectrum of H3K27-altered gliomas: Hemispheric cases with midli...

Mahajan(S),Bhardwaj(S),Singh(J),Vasant(S),... Ann Diagn Pathol 2026-10-00

...PIK3CA, FGFR1, BRAF, NF1, ATRX, and, in one case, PDGFRA, TERT, and TP53. Clinically, two patients died within 3-9 month...

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