...PIK3CA and inhibit ferroptosis. Overexpression of KAT6A or PIK3CA alleviateS the promoting effect of TRERNA1 knockdown o...
...PIK3CA variant. Our study expands the current understanding of PIK3CA-driven oncogenic diversity beyond canonical hotspo...
...PIK3CA mutations. Differential expression analysis indicated that this immune exclusion is structurally maintained by en...
...PIK3CA as key hub genes enriched in the cerebral cortex and basal ganglia. Transcriptomic data confirmed differential ex...
...PIK3CA mutation analysis via MassARRAY PIK3CA Breast Panel and digital droplet PCR. PIK3CA mutations were detected in 42...
...PIK3CA mutations correlated with worse PFS (HR = 2.12, 95% CI: 1.43-3.15, p = 0.002), whereas ERBB2 mutations showed no ...
...PIK3CA H1047R mutations that were undetectable by conventional Sanger sequencing. To evaluate detection sensitivity, we ...
...PIK3CA-mutated tumors, established the basis for biomarker-guided treatment in hormone receptor-positive, HER2-negative ...
...PIK3CA, EGFR, and KRAS. In parallel, germline sequencing revealed pathogenic or likely pathogenic variants in 60% (30/50...
...PIK3CA, FGFR1, BRAF, NF1, ATRX, and, in one case, PDGFRA, TERT, and TP53. Clinically, two patients died within 3-9 month...
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