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Differential sensitivity of MCPH1- and BRCA2-deficient cancer cells to PARP-1...

Chapman(IG),Wu(X),Veuger(S),Jowsey(PA) PLoS One None

...BRCA1 and BRCA2, can be specifically killed by inhibitors of the base excision repair enzyme, poly(ADP-ribose) polymeras...

S100A6 promotes liver metastasis by activating FGFR3 signaling in BAP1-defici...

Li(Y),Zheng(C),Liang(Y),Liu(Y),Zhou(F),Zhu... Oncogene 2026-05-00

...BRCA1-associated protein 1 (BAP1) deficiency strongly correlates with UM metastasis, its mechanistic role remains unclea...

Metabolic reprogramming of tumor-associated macrophage clusters in ovarian ca...

Qi(L),Li(L),Liu(Y),Li(W),Ma(Y),Zhao(M) BioData Min 2026-04-03

...BRCA1, and ATF5, which might be potential therapeutic targets. Cell-cell communication analysis demonstrated that hyperm...

The role of germline mutations in non-small cell lung cancer: A systematic re...

Gentile(G),Gelibter(A),De Marchis(L),Pappa... Crit Rev Oncol Hematol 2026-07-00

...BRCA1/2, TP53, PALB2, CHEK2, and EGFR. Prevalence rates varied by gene, cohort characteristics, ethnicity, and histology...

Investigating the contribution of rare non-coding variants in BRCA1, BRCA2 an...

Zhao(Q),Li(N),Marinovic(E),McInerny(S),Zet... NPJ Breast Cancer 2026-04-04

Pathogenic coding variants in BRCA1, BRCA2 and PALB2 confer hereditary breast/ovarian cancer risk, yet these regions com...

Comparative Analysis of Homologous Recombination Repair Status Across Gynecol...

Huang(Y),Shao(J),Yin(X),Jiang(Y),Luo(J),Hu... Curr Cancer Drug Targets 2026-04-03

...BRCA1/2 and mutations in PALB2 were associated with high HRD scores (≥42). Notably, a subset of patients without germlin...

BRCA2-dependent maturation of nascent strands during DNA replication.

Milano(L),Wells(S),Vaitsiankova(A),Drummon... Mol Cell 2026-04-16

...BRCA1 and BRCA2 and is associated with the BRCA2-dependent accumulation of RAD51 recombinase in chromatin. Our data iden...

Spatial immune profiling complements genomic sequencing in biliary tract canc...

Barsch(M),Godbole(I),Metzger(P),Benzing(M)... ESMO Gastrointest Oncol 2026-06-00

...BRCA1/2, the therapeutic implications of BRCA1-associated protein 1 (BAP1) alterations are unclear. We describe three pa...

Distinct biological and molecular characteristics of breast cancer in young w...

Obeagu(EI) Ann Med Surg (Lond) 2026-04-00

...BRCA1/2, and other DNA repair genes are more prevalent, along with basal-like intrinsic subtypes that exhibit high proli...

Identification of BRCA1-Associated RING Domain 1 Mutation as a Novel Indicato...

Lin(L),Xu(X),Yang(T),Chen(W),Fang(K),Lin(Z... Cancer Manag Res None

...BRCA1-associated RING domain 1) in newly diagnosed multiple myeloma (NDMM), which has not been well defined previously. ...

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