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Christenson(ES),Wala(JA),Parkinson(R),Coll... Nat Commun 2026-07-23

...PIK3CA inhibitor) and nivolumab (anti-PD-1) in metastatic microsatellite stable CRC (NCT03711058): Cohort A: PIK3CAwt (n...

Li(H),Liu(L),Yang(Q),Li(Y),Song(Y),Jiang(J... Mol Med Rep 2026-08-00

...PIK3CA and PIK3CB) were found to be enriched in the EGFR/PI3K/Akt signaling pathway. Molecular docking demonstrated stab...

Rathod(G),Parmar(P) Oncoscience None

...PIK3CA, PTEN, and AKT genes. Moreover, hyperactivation of the MAPK pathway can be caused by overexpression of RTKs, GPCR...

Fanucci(K),Rozenblit(M),Quintanilha(JCF),G... NPJ Breast Cancer 2026-05-20

...PIK3CA mutation (81.8% vs. 37.9%) vs. patients with TMB ≤ 20. Patients with UHTMB who received immunotherapy had longer ...

Barraud(S),Roussel-Simonin(C),Pautier(P),I... Br J Cancer 2026-08-00

...PIK3CA mutations were significantly more frequent in LTR, while STK11 alterations were enriched in NLTR. Durable respons...

Chen(WY),Chen(WC),Tan(PH),Chen(YM),Chuang(... Virchows Arch 2026-05-19

...PIK3CA and KRAS, particularly in case #1. Of note, the case #1 PIK3CA p.Q546K alteration was concordantly identified in ...

Liang(B),Cao(M),Tan(H),Liu(Z),Liu(X) Toxicol Mech Methods 2026-05-22

...PIK3CA, PIK3CD, SRC, and AKT1 as candidate genes potentially relevant to the observed association, and enrichment analys...

Santos(PM),Loureiro(L),Pinelo(A),Machado(R... Port J Card Thorac Vasc Sur... 2026-05-10

...PIK3CA- related overgrowth spectrum (PROS) and PTEN hamartoma tumor syndrome (PHTS). However, sirolimus shows poor or ab...

Trozzi(R),Anderson(G),Romano(V),Iacobelli(... Gynecol Oncol 2026-07-00

...PIK3CA, HRAS, and FGFR3 variants emerged as potential therapeutic targets. Activating BRAF and c-KIT mutations were freq...

Liu(L),Graff(SL),Cheng(L),Wang(Y) Lab Invest 2026-07-00

...PIK3CA inhibitors for hormone receptor-positive (HR+)/human epidermal growth factor receptor 2-negative (HER2-) advanced...