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Age-related genomic characterization and therapeutic targets in Chinese breas...

Sui(XY),Song(XQ),Liu(XY),Shao(ZM),Hu(X),Ch... BMC Med 2026-03-27

...PIK3CA, FOXA1, and TBX3 mutations were more prevalent in elderly patients. By leveraging the aforementioned mutational c...

Age-Associated Genetic Variations in Breast Cancer: Somatic Mutations and Co-...

Ekinci(B),Orenay-Boyacioglu(S),Erdogdu(IH)... Biomedicines 2026-02-25

...PIK3CA, PTEN, RAD50, BLM, NF1, AR, BRCA2, and KMT2C. Notably, PIK3CA mutations were significantly more frequent in geria...

Anthracycline-Free Neoadjuvant Pertuzumab-Trastuzumab-Taxane in Patients with...

Irelli(A),Sidoni(T),Pavese(F),Rotondaro(S)... Biomedicines 2026-03-20

...PIK3CA mutations with anthracycline-free regimens remains unclear. Methods: We retrospectively analyzed 56 patients with...

A Study on the Mechanism of Acetyl Tributyl Citrate-Induced Infertility Toxic...

Sun(X),Chen(P),Han(Y),Du(Y),Sun(S),Miu(J),... Int J Mol Sci 2026-03-23

...PIK3CA, CASP3, HRAS-and four core targets for icariin treatment-IL6, TNF, STAT3, and INS. Gene ontology (GO) and Kyoto E...

Advancements and innovations in the molecular mechanisms and treatment of col...

Wang(X),Yang(J) Discov Oncol 2026-03-10

...PIK3CA, and K-ras, as well as tumor suppressor genes including APC, p53, and PTEN. These genetic changes are further com...

Comprehensive circulating tumor DNA mutation profiling via CAPP-Seq liquid bi...

Iwahashi(N),Noguchi(T),Sakai(K),Yahata(T),... Int J Clin Oncol 2026-05-00

...PIK3CA being the most frequently mutated gene [13/38 (34%)]. Copy number gains of EGFR, MET, and ERBB2 were observed in ...

Treatment Patterns and Clinical Outcomes in Metastatic HR+/HER2- and Triple-N...

Gambaro(K),Rachedi(K),Basik(M),Batist(G),S... Adv Ther 2026-05-00

...PIK3CA/AKT1/PTEN alteration testing/positivity rates, and overall survival (OS), all analyzed descriptively. A total of ...

Therapeutic mechanism of Polygonum multiflorum Thunb. in premature ovarian in...

Li(J),Liu(Y),You(H),Li(S),Lin(C),Zhu(C) J Sci Food Agric 2026-06-00

...PIK3CA, and PIK3R1, with pathway enrichment highlighting the PI3K/AKT signaling pathway, which was further supported by ...

TBCRC 035: randomized phase II pharmacodynamic study of standard and reduced-...

Jacob(S),Mayer(EL),Kacik(N),Storniolo(AM),... ESMO Open 2026-04-00

...PIK3CA and TP53, and higher baseline Ki-67 were associated with shorter PFS. Changes in pRb and Rb were not associated w...

Efficacy and safety of guanxinshutong capsule as adjunctive therapy for unsta...

Li(Y),Yu(L),Wu(L),Peng(W),Li(Q),Huang(P),C... Front Cardiovasc Med None

...PIK3CA, corroborating their therapeutic potential. The combination therapy of GXST and WM significantly boosted clinical...

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