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Gene Mutations and Related Molecular Events in Distant Metastasis of Cervical...

Guo(Y),Li(S),Liu(T),Chang(X),Qin(P),Wang(N... Int J Med Sci None

...PIK3CA mutations significantly influence metastasis. Despite its low incidence, PDGFRA mutation is closely tied to lymph...

Advances in genetics, signaling, and modeling of venous malformations.

Sagar(K),Boscolo(E) Front Cardiovasc Med None

...PIK3CA genes, which disrupt endothelial cell morphogenesis and vessel maturation. VM lesions are typically diagnosed dur...

Coexistent PTEN and PIK3CA alterations hyperactivate mTORC1 signaling in endo...

Solomon(H),Mukherjee(R),Yang(YC),Meredith(... bioRxiv 2026-02-14

...PIK3CA coexistent alterations result in elevated membrane phosphatidylinositol (3,4,5)-trisphosphate (PIP3) levels and m...

A multi-mics exploration of programmed cell death in non-obstructive azoosper...

Yu(Q),Yang(Q),Yuan(S),Zhao(Y),Li(W),Qiao(J... Front Cell Dev Biol None

...PIK3CA. Subsequent MR analysis established TLR4 as being causally associated with an increased risk of NOA. In vitro exp...

PIK3CA mutation in ER-negative and HER2-positive breast cancer with apocrine ...

Nozaki(F),Nakanishi(Y),Hirotani(Y),Kobayas... Breast Cancer 2026-05-00

...PIK3CA mutations (MDA-MB-453: ER-/HER2+/AR + and MFM223: ER-/HER2-/AR+) and one without PIK3CA mutations (HCC1428: ER+/H...

Protective effects of a herbal combination (Dimocarpus longan and Orthosiphon...

Yan(H),Zhu(S),Yu(J),Xu(X),Fu(D),Chen(Y),Da... Food Funct 2026-03-09

...PIK3CA, PIK3CB, and ESR1. These compounds synergistically reduced hepatic triglycerides (-59.3%) and cholesterol (-35.2%...

Clonal Dynamics and Molecular Heterogeneity of Metaplastic Breast Cancer: Foc...

Ye(R),Dai(X),Yang(Z),Zhang(D),Hu(Z),Liao(Y... Breast Cancer (Dove Med Press) None

...PIK3CA (9/16, 56.2%), and MCL1 (10/16, 62.5% amplified). TP53 mutations (primarily frameshift and missense) showed consi...

Gremlin-1 promotes leukemic survival via PI3K/AKT signaling in infant MLL-AF4...

Liu(X),Zhang(Y),Hua(S),Shao(X),Yin(L) Exp Hematol 2026-05-00

...PIK3CA attenuated GREM1-mediated survival effects. In a xenograft model based on pretreated leukemia cells, GREM1 neutra...

Exploring significant gender disparities in esophageal cancer risk: Insights ...

Cui(J),Zhang(R),Zhang(X),Zhang(Z),Li(M),He... Medicine (Baltimore) 2026-02-27

...PIK3CA proteins had no statistically significant impact on the survival of EC patients (PTEN: Log-rank P = .89, HR = 1.1...

Intimal sarcomas (ISarc) of the cardiac chambers (CC) of the heart and great ...

Zerdan(MB),Pavlick(D),Zaccarini(DJ),Ross(J... Cardiooncology 2026-02-28

...PIK3CA mutations were significantly more frequent in CC (20% vs 0%, P=0.007); ERBB3 mutations were infrequent and not si...

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