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Wortmannin exhibits anticancer activity in oral cancer cell line by targeting...

Kumbhar(G),Suryawanshi(P),Ladke(V) Avicenna J Phytomed None

...PIK3CA, PTGS2, MAPK8, AR, TERT, PIK3CB, PARP1, and PIK3CG. Wortmannin may treat oral cancer by targeting the PI3K/AKT si...

Next-Generation Sequencing-Based Analysis of the Genetic Mutation Spectrum in...

Xu(H),Luo(R),Chen(W),Sun(Q),Chen(H),Liu(K)... Mol Carcinog 2026-07-00

...PIK3CA (18.9%). TP53 mutations were significantly enriched in left-sided colon cancers (p < 0.0001). In contrast, both K...

Network Pharmacology-Serum Metabolomics Integration Identifies Key Targets, B...

Zhou(F),Li(J),Zhou(Y),Zhang(X),Luo(J),Li(X... Int J Gen Med None

...PIK3CA, and PIK3R1 emerging as key targets involved in PI3K-AKT and HIF-1 signaling. SD-4 treatment significantly reduce...

Unusual Vascular Anomalies in Plastic Surgery: A Case Series.

Sharma(SC),Jester(A),Vidyadharan(R) Ann Plast Surg 2026-07-01

...PIK3CA-related overgrowth spectrum disorder presenting with multifocal osteolytic lesions and fractures. Diagnoses were ...

High tumor mutational burden and PIK3CA mutations correlate with poor Merkel ...

Lobo(M),Bahar(F),Schnabel(JL),Neto(JPD),Sh... JCI Insight 2026-04-22

...PIK3CA (HR = 2.07 [95% CI, 1.10-3.88]; P = 0.024) remained significant. PIK3CA remained significant across prespecified ...

Emerging Molecular Insights and Targeted Therapeutics in Colorectal Cancer: F...

Israni(DK),Shah(J),Shah(M),Chauhan(H),Praj... J Gastrointest Cancer 2026-03-24

...PIK3CA, PTEN, SMAD2, SMAD4, and c-MYC are oncogenic and tumor suppressor genes that are frequently altered in CRC. These...

Hypoxia and aspirin additively increase intracellular glutamine accumulation ...

Umezaki(N),Boku(S),Matsuo(Y),Yamamoto(T),S... Sci Rep 2026-03-24

...PIK3CA-MT) cells. RNA sequencing was performed on PIK3CA-wild type (WT)/mutant isogenic SW48 cell lines to assess aspiri...

Analysis of PIK3CA mutations in the lysate of sentinel lymph nodes in patient...

Park(SA),Masunaga(N),Kin(T),Tokui(R),Sato(... Front Oncol None

...PIK3CA mutations, OSNA lysates were analyzed to detect PIK3CA mutations in the SN by using droplet digital polymerase ch...

Insights From Mutational and Transcriptomic Profiles in Epithelial-myoepithel...

Alsugair(Z),Descotes(F),Champagnac(A),Lope... Am J Surg Pathol 2026-07-01

...PIK3CA , STAT5B , and NOTCH1 , as well as gene fusions such as HMGA2 :: WIF1 and FBXO32 :: PLAG1 . A comparative analysi...

BRAFV600E patient derived colon cancer organoids identify biomarkers of respo...

Kotarac(A),Osumi(H),Malt(A),Alp(KM),Jarosc... J Exp Clin Cancer Res 2026-03-25

...PIK3CA/p-AKT axis as mechanism of primary sensitivity while ROS pathway inhibition as driver for primary resistance. Fin...

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