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The Reproductive Toxicity Valuation of Deoxynivalenol: An Integrated Study fr...

Dou(L),Tang(Y),Yuan(S),Xu(F),Wang(Y),He(Q)... Int J Mol Sci 2026-03-27

...PIK3CA, PIK3R1, and SRC were identified as key targets involved in DON-induced reproductive injury. For testicular injur...

Network Pharmacology-Guided Identification of Candida albicans Secondary Meta...

Oduro-Kwateng(E),Anyaneji(UJ),Fanele(A),Nt... Int J Mol Sci 2026-03-30

...PIK3CA, MAPK3, EGFR, MTOR, and AKT1) were consistently annotated within the top 30 KEGG pathways and displayed strong bi...

Hepatotoxic Mechanisms of Polyethylene Terephthalate Microplastics Revealed b...

Tan(X),Zhang(M),Lu(J),Shi(S),Shi(X),Hou(Z) Int J Mol Sci 2026-04-03

...PIK3CA, PIK3CB, PIK3CD, PIK3R1, and SRC), all components of the PI3K/AKT signaling pathway. Gene ontology analysis showe...

The Molecular Signature of Early-Onset Colorectal Cancer Liver Metastases: Di...

Tsokkou(S),Konstantinidis(I),Chatzikomnits... Int J Mol Sci 2026-04-04

...PIK3CA-mutant tumors, where aspirin and ferroptosis inducers show synergistic potential. Clinically, high-risk EOCRC pat...

PIK3CA mutant cervical cancer is selectively suppressed by PI3Kα inhibition (...

Lou(H),Langan(D),Syracuse(N),Murphy(EA),Ki... Neoplasia 2026-06-00

...PIK3CA wild-type without YAP1 amplification, (II) PIK3CA-mutant without YAP1 amplification, and (III) PIK3CA wild-type w...

Identification of pathological CD133+ endothelial cells in venous malformations.

Shawber(CJ),Clapp(A),Shapiro-Franklin(N),Y... Front Cardiovasc Med None

...PIK3CA and TEK. CD133+ VMECs had increase proliferation and a subset had increase nuclear phospho-AKT. When implanted in...

Targeting the chromatin modifying enzyme, KDM5C, enhances AKT inhibition resp...

Cutano(V),Dunn(S),Park-Chouinard(S),Wigmor... Mol Cancer Ther 2026-03-15

...PIK3CA, PTEN and AKT-1 altered estrogen receptor positive breast cancer (ER+ BC). A genome-wide CRISPR screen was perfor...

A natural defense against particulate matter 10 (PM10): Network pharmacology-...

Jo(HS),Hwang(J),Kim(MJ),Jeong(JH),Choi(JM)... Ecotoxicol Environ Saf 2026-05-00

...PIK3CA, AKT1, and MAPK1/3. Our PM10-induced lung inflammation model systems validated that CZL reduced PM10-induced phos...

Clinicopathologic features of KRAS G12C-mutated non-small cell lung carcinoma...

Bradová(M),Slavík(P),Vaněček(T),Martínek(P... Virchows Arch 2026-07-00

...PIK3CA, and CTNNB1 mutations occurred in four cases each, MET in two cases, and BRAF, FGFR2, FGFR3, and GNAS in one case...

Detection rate and mutational landscape in extracranial arteriovenous malform...

Schmidt(VF),Schanze(D),Brill(R),Loeser(JH)... BMC Med 2026-04-16

...PIK3CA (3.5%, 4/114), SOS1 (2.6%, 3/114), GNAQ (1.8%, 2/114), and RIT1, RAF1, and GNA14 (each 0.9%, 1/114). Within the R...

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