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Genetic analysis of microglandular adenosis and acinic cell carcinomas of the b…

Geyer(Felipe C),Berman(Samuel H),Marchiò(Cat… Mod Pathol 0000-00-00

...PIK3CA, and INPP4B. Recurrent (n=2) somatic mutations restricted to microglandular adenosis or acinic cell carcinomas in...

Colorectal carcinomas with submucosal invasion (pT1): analysis of histopatholog…

Pai(Reetesh K),Chen(Yuwei),Jakubowski(Mauree… Mod Pathol 0000-00-00

...PIK3CA and AKT, P=0.02). In conclusion, this study demonstrates the importance of identifying high tumor budding in pT1 ...

PIK3CA Mutations in Resected Small Cell Lung Cancer.

Han(Na),Cheng(Qiao-Yuan),Chen(Bo),Cai(Ju-Fen… Adv Clin Exp Med 0000-00-00

...PIK3CA) gene, which encodes the p110α catalytic subunit, plays a key role in the activation of AKT downstream signaling ...

Accession of Tumor Heterogeneity by Multiplex Transcriptome Profiling of Single…

Gorges(Tobias M),Kuske(Andra),Röck(Katharina… Clin Chem 0000-00-00

...PIK3CA and MTOR) or cross talks between tumors and immune cells (e.g., CCL4, CXCL2, CXCL9, IL15, IL1B, or IL8).,Multimar...

Genomic characterization of liver metastases from colorectal cancer patients.

Sayagués(José María),Corchete(Luís Antonio),… Oncotarget 0000-00-00

...PIK3CA, PTEN and EGFR), endocytosis (e.g., the PDGFRA, SMAD2, ERBB3, PML and FGFR2), and the cell cycle (e.g., SMAD2, CC...

Breast cancer genome and transcriptome integration implicates specific mutation…

Smid(Marcel),Rodríguez-González(F Germán),Si… Nat Commun 0000-00-00

...PIK3CA, PTEN, CCND1 and CDH1. We find that CCND3 expression levels do not correlate with amplification, while increased ...

Loss of HDAC-Mediated Repression and Gain of NF-κB Activation Underlie Cytokine…

Kim(Minchul),Lu(Falong),Zhang(Yi) Cell Rep 0000-00-00

ARID1A is frequently mutated in ovarian clear cell carcinoma (OCCC) and often co-exists with activating mutations of PIK...

Repression of p63 and induction of EMT by mutant Ras in mammary epithelial cell…

Yoh(Kathryn E),Regunath(Kausik),Guzman(Asja)… Proc Natl Acad Sci U S A 0000-00-00

...PIK3CA) oncogenes strongly repress expression of ∆Np63α, the predominant p63 isoform in basal mammary epithelial cells. ...

Somatic mutation, copy number and transcriptomic profiles of primary and matche…

Fumagalli(D),Wilson(T R),Salgado(R),Lu(X),Yu… Ann Oncol 0000-00-00

...PIK3CA, KRAS, AKT1, FGFR3, HRAS and BRAF at frequencies of 41%, 6%, 5%, 2%, 1% and 2%, respectively, and CN amplificatio...

First-in-human phase I study of copanlisib (BAY 80-6946), an intravenous pan-cl…

Patnaik(A),Appleman(L J),Tolcher(A W),Papado… Ann Oncol 0000-00-00

...PIK3CA, KRAS, BRAF, and PTEN mutational status and PTEN immunohistochemistry. Whole-body [(18)F]-fluorodeoxyglucose posi...

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