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Evaluation of PTEN loss and PIK3CA mutations and their correlation with effic...

Nishimura(Reiki),Arima(Nobuyuki),Toyoshima... Mol Clin Oncol 0000-00-00

...PIK3CA mutation and p95HER2 expression have been reported to potentially be responsible for the poor response to T. This...

Breast cancer genome and transcriptome integration implicates specific mutati...

Smid(Marcel),Rodríguez-González(F Germán),... Nat Commun 0000-00-00

...PIK3CA, PTEN, CCND1 and CDH1. We find that CCND3 expression levels do not correlate with amplification, while increased ...

A phase IB study of AMG 479, a type 1 insulin-like growth factor receptor (IG...

Sarantopoulos(J),Mita(A C),Mulay(M),Romero... J Clin Oncol 0000-00-00

...PIK3CA & RAS mutation) will be presented. [Table: see text] [Table: see text].

Distinct PIK3CA mutation profiles in estrogen receptor (ER) negative breast c...

Doane(A S),Danso(M),Lal(P),Donaton(M),Whel... J Clin Oncol 0000-00-00

...PIK3CA exons 9 and 20 were sequenced by RT-PCR amplification, direct sequencing, and restriction enzyme digest.,Genes di...

Improved clinical and cell cycle response with an mTOR inhibitor, daily oral ...

Baselga(J),van Dam(P A),Greil(R),Gardner(H... J Clin Oncol 0000-00-00

...PIK3CA and exons 5-8 of TP53, and at baseline and day 15 for Ki67, phospho-Akt S473, phospho-S6, PTEN, CyclinD1, ER, PR,...

PIK3CA as a molecular target in mantle cell lymphoma.

Papageorgiou(S),Psyrri(A),Liakata(E),Scori... J Clin Oncol 0000-00-00

...PIK3CA gene copy number. PIK3CA gene mutations were not identified. In addition, amplification of PIK3CA correlated with...

PIK3CA mutations in breast cancer: A potential predictive marker.

Santarpia(M),Altavilla(G),Margeli(M),Mesit... J Clin Oncol 0000-00-00

639 Background: Somatic mutations in phosphoinositide-3-kinase catalytic alpha (PIK3CA) activates Akt, attenuates apopto...

Mutational profiling of protein kinases in prostate carcinoma.

Andea(A),Osman(I),Scardino(P),Scher(H),Ger... J Clin Oncol 0000-00-00

...PIK3CA). We also sequenced PTEN, p53 and AR because of their known association with prostate cancer and interactions wit...

Effects of chromosomes 1, 3, 10 and 17 alterations on patient response to tra...

Jewell(S S),Morrison(L E),Usha(L),Blondin(... J Clin Oncol 0000-00-00

...PIK3CA, AKT3, PTEN, 1q25 and the centromeres (cen) of chromosomes 3, 10, and 17 with response in metastatic ERBB2-amplif...

Mutational profiling of the oncogenome in non-small cell lung cancer (NSCLC).

Pao(W),McLellan(M D),Pham(D K),Singh(B),Ru... J Clin Oncol 0000-00-00

...PIK3CA, BRAF, KRAS, and p53. Two of these mutations are now known to have direct clinical relevance; mutations in the EG...

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