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TP53 BRCA1 CRISPR single-cell cancer

Santarpia(M),Altavilla(G),Margeli(M),Mesit... J Clin Oncol 0000-00-00

639 Background: Somatic mutations in phosphoinositide-3-kinase catalytic alpha (PIK3CA) activates Akt, attenuates apopto...

Andea(A),Osman(I),Scardino(P),Scher(H),Ger... J Clin Oncol 0000-00-00

...PIK3CA). We also sequenced PTEN, p53 and AR because of their known association with prostate cancer and interactions wit...

Jewell(S S),Morrison(L E),Usha(L),Blondin(... J Clin Oncol 0000-00-00

...PIK3CA, AKT3, PTEN, 1q25 and the centromeres (cen) of chromosomes 3, 10, and 17 with response in metastatic ERBB2-amplif...

Pao(W),McLellan(M D),Pham(D K),Singh(B),Ru... J Clin Oncol 0000-00-00

...PIK3CA, BRAF, KRAS, and p53. Two of these mutations are now known to have direct clinical relevance; mutations in the EG...

Layton(Meredith J),Rynkiewicz(Natalie K),I... Biosci Rep 0000-00-00

...PIK3CA lead to an increase in intrinsic phosphoinositide kinase activity, but it is thought that increased access of PI3...

Maru(Yoshiaki),Tanaka(Naotake),Ohira(Miki)... Gynecol Oncol 0000-00-00

...PIK3CA gene was the most common (28%) as previously reported. Seven genes (PIK3CA, ARID1A, CTNNB1, CSMD3, LPHN3, LRP1B, ...

Bhagirath(Divya),Zhao(Xiangshan),Mirza(Sam... PLoS One 0000-00-00

...PIK3CA mutations are commonly associated with most breast cancer subtypes. More recently PIK3CA mutations have been show...

Henry(Whitney S),Laszewski(Tyler),Tsang(Ti... Cancer Res 0000-00-00

...PIK3CA. Here we show that mutant PIK3CA-expressing breast cancer cells have greater sensitivity to aspirin-mediated grow...

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